In this paper we discuss correlation function computations in massive topological Landau-Ginzburg orbifolds, extending old results of Vafa. We then apply these computations to provide further tests of the nonabelian mirrors proposal and two-dimensional Hori-Seiberg dualities with $(S)O_{\pm}$ gauge groups and their mirrors.
In this paper, an input coupler for Ka band gyrotron TWT (Traveling Wave Tube) has been designed. This input coupler can convert a TE10 rectangular waveguide mode into a TE01 cylindrical waveguide mode. The measured results agree well with the simulated results. With the measured -3dB bandwidth of more than 5GHz, the input coupler can be well used in the experiment of Ka band gyrotron traveling wave amplifier.
In this paper, an input coupler for W band gyrotron TWT (Traveling Wave Tube) has been designed. This input coupler has the ability of efficiently converts a TE10 rectangular waveguide mode into a TE01 cylindrical waveguide mode. The measured results agree well with the simulated results. With the measured -2dB bandwidth of more than 4GHz, the input coupler can be well used in the experiment of W band gyrotron traveling wave amplifier.
Abstract The increasing development of hydrogen energy requires us to continuously update the technology of hydrogen production and promote the more rapid development of hydrogen energy. Among them, the electrolysis of water to produce hydrogen is the current research hotspot. In this paper, a simple synthesis method is used to prepare amorphous nano‐scale monometallic Ni and bimetallic Ni, Fe boron phosphides, which are used as electrocatalysts to catalyze water splitting. We explored the best ratio of B to P in monometallic boron phosphides, and the optimal ratio of Ni and Fe in the bimetallic boron phosphide. It shows that when the ratio of B to P is 1 : 5 and the iron content is 0.2 in the Ni‐Fe‐BP, the catalytic performance of the material is optimal. It shows outstanding performance of 310 mV overpotential at a current density of 20 mA cm −2 , and its hydrogen evolution reaction overpotential is only 258 mV, which is better than noble metal materials. At the same time, it maintains excellent stability for 12 h at a constant potential. This work provides a better choice for subsequent research on non‐precious metal catalyst materials.
We present a deep learning-based method for estimating the neutrino energy of charged-current neutrino-argon interactions. We employ a recurrent neural network (RNN) architecture for neutrino energy estimation in the MicroBooNE experiment, utilizing liquid argon time projection chamber (LArTPC) detector technology. Traditional energy estimation approaches in LArTPCs, which largely rely on reconstructing and summing visible energies, often experience sizable biases and resolution smearing because of the complex nature of neutrino interactions and the detector response. The estimation of neutrino energy can be improved after considering the kinematics information of reconstructed final-state particles. Utilizing kinematic information of reconstructed particles, the deep learning-based approach shows improved resolution and reduced bias for the muon neutrino Monte Carlo simulation sample compared to the traditional approach. In order to address the common concern about the effectiveness of this method on experimental data, the RNN-based energy estimator is further examined and validated with dedicated data-simulation consistency tests using MicroBooNE data. We also assess its potential impact on a neutrino oscillation study after accounting for all statistical and systematic uncertainties and show that it enhances physics sensitivity. This method has good potential to improve the performance of other physics analyses.
In this article, the possibility of using a high power klystron amplifier simultaneously as a microwave power source as usual and an electron bunches source by extracting the spent beam with a magnet and also as an oscillator by feedback is investigated. The purpose of this study is to demonstrate the feasibility of constructing a very compact electron linear accelerator or for other applications of electron bunches. The feasibility of the idea was first examined by computer simulation of the electron motion in a 5 MW klystron and the characteristics of the klystron spent beam. Experimental study was then carried out by installing a radio frequency cavity and a Faraday cage in sequence at the exit end of a bending magnet located at the top of the klystron collector. The energy and current of the chopped spent electron beam can then be measured. By properly choosing the feedback circuit elements, the frequency stability of the klystron in oscillator mode was proved to be good enough for linac operation. According to the results presented in this article, it is evident that an extremely compact linac for research and education with better affordability can be constructed to promote the applications of linacs.
Abstract Background: Overexpression of epidermal growth factor receptor 3 (HER3 or ERBB3) has been reported in various cancers, including lung, prostate, head and neck, breast, and ovarian cancers, and is associated with disease progression and poor prognosis. DB-1310 is an antibody-drug conjugate (ADC) comprised of a humanized anti-HER3 IgG1 monoclonal antibody, covalently linked to a proprietary DNA topoisomerase I inhibitor (P1021) via a maleimide tetrapeptide-based cleavable linker, with a high drug-to-antibody ratio (~8). Preclinical studies of DB-1310 demonstrated promising antitumor activity in solid tumors and a tolerable safety profile, warranting further clinical development. Methods: This global, first-in-human, Phase 1/2a study includes dose escalation and expansion parts to assess the safety, tolerability, pharmacokinetics, and antitumor activity of DB-1310 in patients (pts) with pretreated advanced/metastatic solid tumors (NCT05785741). Eligible pts must have progressed on or after standard systemic anticancer treatments have ECOG PS ≤1, and evidence adequate organ function. Phase 1 part will evaluate 5 ascending dose levels of DB-1310 with a standard “3+3” design to identify the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) in pts with advanced/metastatic solid tumors. Phase 2a part will initiate after MTD and/or RP2D are determined and enroll pts with non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) activating mutation, NSCLC without EGFR activating mutation, castration-resistant prostate cancer, head and neck squamous cell carcinoma, and HER2-positive (immunohistochemistry [IHC] 3+, or IHC 2+ and in situ hybridization-positive) breast cancer (BC). DB-1310 is administrated intravenously every 3 weeks as monotherapy, or plus trastuzumab in pts with HER2-positive BC only, until discontinuation criteria are met. The study plans to enroll approximately 95 pts in Phase 1 and 192 in Phase 2a from the United States and China. Citation Format: Aaron Lisberg, Shun Lu, Alexander Starodub, Harshad Amin, Julia Rotow, Lin Wu, Alexander Spira, Erika Hamilton, Weidi Shen, Liming Liu, Zhongyuan Zhu, Wei Gu, Yang Qiu, Rong Shi, Shengxue Liu. A phase 1/2a, multicenter, open-label, non-randomized first-in-human study to assess the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of DB-1310 (a HER3-targeting ADC) in patients with advanced/metastatic solid tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr CT168.
We present the first measurement of the cross section of Cabibbo-suppressed Λ baryon production, using data collected with the MicroBooNE detector when exposed to the neutrinos from the main injector beam at the Fermi National Accelerator Laboratory. The data analyzed correspond to 2.2×10^{20} protons on target running in neutrino mode, and 4.9×10^{20} protons on target running in anti-neutrino mode. An automated selection is combined with hand scanning, with the former identifying five candidate Λ production events when the signal was unblinded, consistent with the GENIE prediction of 5.3±1.1 events. Several scanners were employed, selecting between three and five events, compared with a prediction from a blinded Monte Carlo simulation study of 3.7±1.0 events. Restricting the phase space to only include Λ baryons that decay above MicroBooNE's detection thresholds, we obtain a flux averaged cross section of 2.0_{-1.7}^{+2.2}×10^{-40} cm^{2}/Ar, where statistical and systematic uncertainties are combined.
In this paper we discuss Bagger-Witten line bundles over moduli spaces of SCFTs. We review how in general they are `fractional' line bundles, not honest line bundles, twisted on triple overlaps. We discuss the special case of moduli spaces of elliptic curves in detail. There, the Bagger-Witten line bundle does not exist as an ordinary line bundle, but rather is necessarily fractional. As a fractional line bundle, it is nontrivial (though torsion) over the uncompactified moduli stack, and its restriction to the interior, excising corners with enhanced stabilizers, is also fractional. It becomes an honest line bundle on a moduli stack defined by a quotient of the upper half plane by a metaplectic group, rather than SL(2,Z). We review and compare to results of recent work arguing that well-definedness of the worldsheet metric implies that the Bagger-Witten line bundle admits a flat connection (which includes torsion bundles as special cases), and give general arguments on the existence of universal structures on moduli spaces of SCFTs, in which superconformal deformation parameters are promoted to nondynamical fields ranging over the SCFT moduli space.
