Ajeet Singh

Baylor College of Medicine

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Shailesh Kumar

National Institute of Plant Genome Research

Shafaque Zahra

National Institute of Plant Genome Research

Shelly Praveen

Indian Agricultural Research Institute

Vanita Pandey

Tata Main Hospital

Gyanendra Pratap Singh

National Bureau of Plant Genetic Resources

Sawani Datta

Tata Institute of Fundamental Research

Om Prakash Gupta

Indian Institute of Wheat and Barley Research

Sewa Ram

Indian Institute of Wheat and Barley Research

Avinash Gupta

Tata Memorial Hospital

Ramesh Chand Meena

University of Rajasthan

Cooperative Institutions

National Institute of Plant Genome Research

Indian Agricultural Research Institute

Indian Council of Agricultural Research

Guru Angad Dev Veterinary and Animal Sciences University

Defence Institute of Physiology and Allied Sciences

Indian Institute of Wheat and Barley Research

National Dairy Research Institute

Indian Institute of Soybean Research

Defence Research and Development Organisation

Chaudhary Charan Singh Haryana Agricultural University

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Studies On Diversity And Inheritance Of Isozyme Polymorphism In Grape Genotypes

Ajeet Singh

Inheritance

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Summaries of oral sessions at the XXI World Congress of Psychiatric Genetics, Boston, Massachusetts, 17–21 October 2013

Psychiatric Genetics (2014)

Hilary Akpudo Branko Aleksić Anna Alkelai Christie L. Burton Tania Carrillo‐Roa

The XXI World Congress of Psychiatric Genetics (WCPG), sponsored by the International Society of Psychiatric Genetics (ISPG), took place in Boston, Massachusetts, on 17–21 October 2013. Approximately 900 participants gathered to discuss the latest findings in this rapidly advancing field. The following report was written by student travel awardees. Each was assigned one or more sessions as a rapporteur. This manuscript represents topics covered in most, but not all of the oral presentations during the conference, and contains some of the major notable new findings reported.

Psychiatric genetics

10.1097/ypg.0000000000000043

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Citations (4)

Effect of Temperature on Symptoms Expression and Viral RNA Accumulation in Groundnut Bud Necrosis Virus Infected Vigna unguiculata.

PubMed (2018)

Ajeet Singh Vipin Permar Basavaraj Basavaraj Bhoopal Singh Tomar Shelly Praveen

Groundnut bud necrosis virus (GBNV) (Tospovirus genus, Bunyaviridae family) infects the major crops of solanaceae, leguminosae and cucurbitaceae in India. Temperature is an important factor which influences the plant growth and development under diseased conditions.In the present study, we evaluated the effect of four different temperatures on the symptoms expression and viral RNA accumulation in the GBNV inoculated cowpea plants.For the evaluation of viral symptoms and RNA accumulation, we used 2-3 leaf stage cowpea plants grown in the controlled conditions. GBNV was mechanically inoculated by sap method to the cowpea plants and inoculated plants were incubated at four different temperatures (30, 25, 20 and 15 °C).The first visible symptom of GBNV infection at the inoculated site was observed in the form of chlorotic spots which were converted into the necrotic spots as the infections succeeded. Some yellow mosaic symptoms were also observed at the systemic site during viral infection cycle. Plants incubated at higher (30 and 25 °C) temperatures showed a severe necrosis and a higher viral RNA accumulation at the inoculated site and facilitated the viral spread at the systemic site. However, viral RNA accumulation was less at the systemic site than the inoculated site. In contrast, symptoms' expression and viral RNA accumulation were decreased at the inoculated site at low (20 and 15 °C) temperatures, no viral symptoms were observed at the systemic site (15 °C); in addition to viral RNA accumulation suppression at this site. GBNV infection at the inoculated site induced the higher accumulation of H2O2 followed by the induction of cell death at higher temperatures (30 and 25 °C) than the lower (20 and 15 °C) temperatures.This study suggests that viral RNA accumulation parallels with the H2O2 production and induction of cell death by GBNV infection in cowpea plants is temperature dependent.

10.15171/ijb.1846

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Citations (8)

In Silico Methods for the Identification of Viral-Derived Small Interfering RNAs (vsiRNAs) and Their Application in Plant Genomics

Methods in molecular biology (2022)

Aditya Narayan Shafaque Zahra Ajeet Singh Shailesh Kumar

Identification

10.1007/978-1-0716-1875-2_4

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Citations (1)

Mitochondrial and Chloroplast Genomes

Compendium of plant genomes (2021)

S. V. Ramesh M. K. Rajesh Ajeet Singh K. B. Hebbar

10.1007/978-3-030-76649-8_9

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Retrotransposons-based genetic regulation underlies the cellular response to two genetically diverse viral infections in tomato

Physiological and Molecular Plant Pathology (2022)

Ajeet Singh Suneha Goswami T. Vinutha R. K. Jain S. V. Ramesh

Retroposon

Retrotransposon

10.1016/j.pmpp.2022.101839

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Differentially expressed seed aging responsive heat shock protein OsHSP18.2 implicates in seed vigor, longevity and improves germination and seedling establishment under abiotic stress

Frontiers in Plant Science (2015)

Harmeet Kaur Bhanu Prakash Petla Nitin Uttam Kamble Ajeet Singh Venkateswara Rao

Small heat shock proteins (sHSPs) are a diverse group of proteins and are highly abundant in plant species. Although majority of these sHSPs were shown to express specifically in seed, their potential function in seed physiology remains to be fully explored. Our proteomic analysis revealed that OsHSP18.2, a class II cytosolic HSP is an aging responsive protein as its abundance significantly increased after artificial aging in rice seeds. OsHSP18.2 transcript was found to markedly increase at the late maturation stage being highly abundant in dry seeds and sharply decreased after germination. Our biochemical study clearly demonstrated that OsHSP18.2 forms homooligomeric complex and is dodecameric in nature and functions as a molecular chaperone. OsHSP18.2 displayed chaperone activity as it was effective in preventing thermal inactivation of Citrate Synthase. Further, to analyze the function of this protein in seed physiology, seed specific Arabidopsis overexpression lines for OsHSP18.2 were generated. Our subsequent functional analysis clearly demonstrated that OsHSP18.2 has ability to improve seed vigor and longevity by reducing deleterious ROS accumulation in seeds. In addition, transformed Arabidopsis seeds also displayed better performance in germination and cotyledon emergence under adverse conditions. Collectively, our work demonstrates that OsHSP18.2 is an aging responsive protein which functions as a molecular chaperone and possibly protect and stabilize the cellular proteins from irreversible damage particularly during maturation drying, desiccation and aging in seeds by restricting ROS accumulation and thereby improves seed vigor, longevity and seedling establishment.

Accelerated aging

10.3389/fpls.2015.00713

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Citations (129)

Effect of dietary protein, lipid and carbohydrate contents on the liver composition and enzyme activity of Cyprinus carpio communis fingerlings

International Journal of Fisheries and Aquaculture (2012)

Muzaffar Ahmad T. A. Qureshi Ajeet Singh

This study aimed to determine a feed formulation with best protein to energy ratio which would result in better liver composition and enzyme activity of Cyprinus carpio communis. Fingerlings having average weight 1.64 g ± 0.13 and length 5.26 ± 0.10 cm were fed on four different formulated feeds and a control feed (each in a triplicate set), 6% of their body weight, three times a day, during 90 days. Feeds were formulated using ground nut oil cake, mustard oil cake, rice bran, wheat bran, fish meal and soybean meal in order to suffice the balanced need of protein and energy of the common carp. Liver composition and acid and alkaline phosphatase activity of fingerlings were measured. There was a significant increase in liver lipid content with the increase in dietary carbohydrate level. The ACP and ALP activity was the maximum in the fingerlings fed on the diet having optimum protein to energy ratio of 20.54 mg protein/Kj. This work concluded that a diet containing 40% protein, 9.31% lipid and 10.08% carbohydrate is the best one for a more profitable and successful culture of the common carp. Key words: Protein to energy ratio, carp production, acid phosphatase, alkaline phosphatase.

Common carp

10.5897/ijfa11.082

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Citations (2)

In silico analysis and modeling of putative T cell epitopes for vaccine design of Toscana virus

3 Biotech (2014)

Amisha Jain P. Tripathi Aniket Shrotriya Ritu Chaudhary Ajeet Singh

The sandfly fever Toscana virus is an important etiological agent known to cause human neurological infections in endemic Mediterranean countries during summer season. In the present study, prediction and modeling of T cell epitopes of Toscana virus (TOSV) antigenic proteins followed by the binding simulation studies of predicted highest binding scorers with their corresponding MHC class II alleles were done. Immunoinformatics was applied in computational vaccinology to analyze the viral proteins which generate possible outcomes to elicit vaccine for TOSV. Here, immunoinformatic tool ProPred was used to predict the promiscuous MHC class II epitopes of viral antigenic proteins. The molecular modeling of the selected epitopes as well as MHC alleles was done at CPH model 3.2 server. Molecular dynamics (MD) simulation studies were performed through the NAMD graphical user interface embedded in visual molecular dynamics. The epitope/peptide VKMMIVLNL of viral nucleoprotein as well as VMILGLLSS of viral glycoprotein has shown the highest binding score with the same DRB1*1104 MHC II allele. These two predicted peptides are highly potential to induce T cell-mediated immune response and are expected to be useful in designing epitope-based vaccines after further testing. The results signify that the nucleoprotein, glycoprotein or the combination of both could be useful for future development of a vaccine controlling the spread of this emerging virus that could pose a new threat for humans.

Nucleoprotein

Epitope mapping

Peptide vaccine

10.1007/s13205-014-0247-4

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Citations (7)

PROTEIN l-ISOASPARTYL METHYLTRANSFERASE1 (CaPIMT1) from chickpea mitigates oxidative stress-induced growth inhibition of Escherichia coli

Planta (2009)

Pooja Verma Ajeet Singh Harmeet Kaur Manoj Majee

10.1007/s00425-009-1050-z

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Citations (25)