Secondary spontaneous pneumothorax almost always develops secondary to an underlying lung disease. A pneumothorax secondary to a malignancy is very rare, and is observed most frequently in soft tissue sarcomas. Pazopanib, a tyrosine kinase inhibitor, is used in metastatic soft tissue sarcomas treatment. The rate of pneumothorax that is caused by pazopanib is about 14% in the literature. The patient being presented in this article underwent surgery for soft tissue sarcoma, postoperatively received pazopanib (Votrient® 400 mg, oral, Glaxo Group Ltd, Brentford, UK) treatment due to widespread bilateral lung metastases, and developed synchronous spontaneous pneumothorax.
Amac: Bu calismanin amaci Duzce Universitesi Orman Fakultesi Ogrencilerinin sigara, alkolve diger bagimlilik olusturan maddeleri kullanma sikligini ve kullanmaya baslama nedenlerinibelirlemektir. Gerec ve Yontem: Arastirmanin evreni ve orneklemi Duzce Universitesi Orman Fakultesi’ndeokuyan 489 ogrencidir. Arastirmanin anket formunda, sosyo-demografik ozelliklerle ilgili 24soru, sigara ile ilgili 8 soru, alkol ile ilgili 6 soru ve madde kullanimi ile ilgili 7 soru bulunmaktaidi. Bulgular: Orman Fakultesinde okuyan 489 ogrenciden 398 (%81.4)’ine anket uygulandi.Sigara icme sikligi %41.6, alkol %40.3 ve madde kullanimi %9.3 olarak bulundu. Sigara vealkole baslama nedenleri; cevre etkisi, ozenti, merak, arkadas etkisi olarak belirtildi. Sonuc: Universite ogrencilerinin sigara, alkol ve madde kullanim sikliklari arastirmalarlasaptanmali ve ogrencilerin bu maddeleri kullanmaya baslama nedenleri onlenmesi icinbelirlenmelidir
Mediastinoscopy is an invasive procedure that is used in the diagnosis of mediastinal diseases and in staging lung cancer. Tumor cell seeding during mediastinoscopy along the mediastinum and the incision line is a very rare complication. This study aimed to test the safety of mediastinoscopy in terms of tumor seeding by cytological evaluation of mediastinal lavage samples taken before and after biopsy.The patients who underwent mediastinoscopy in our hospital between 2011 and 2014 were studied prospectively. Seventy-three patients with a diagnosis of lung or mediastinal malignancy were included in the study. All patients underwent classical cervical mediastinoscopy and mediastinal lavages were taken before and after the biopsy. Both lavage samples were sent to the pathology department in syringes for malignant cell cytology screening.The results of the histopathological examinations of lymph node biopsies were reactive in 25 patients and positive for malignancy in 48 patients. In 2 of 48 patients whose lymph nodes were reported to be positive for malignancy, the mediastinal lavage sample was reported to be positive for malignancy after biopsy, although it was negative preoperatively. In two patients, both the pre- and postbiopsy lavage samples were reported to be positive for malignancy.While performing dissection and biopsy during mediastinoscopy, tumor seeding into the mediastinum may occur. Long follow-up periods and large patient series are needed to determine how cytopathological examination of both fluids would affect the prognosis.
