Dejan Gođevac

University of Belgrade

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Vele Tešević

University of Belgrade

KŠ

Katarina Šavikin

Institute for Plant Protection and Environment

Gordana Zdunić

Institute for Plant Protection and Environment

Slobodan Milosavljević

Serbian Academy of Sciences and Arts

Nebojša Menković

Institute for Plant Protection and Environment

Boban Anđelković

University of Belgrade

Ljubodrag Vujisić

University of Belgrade

Vlatka Vajs

Institute of Chemistry, Technology and Metallurgy

Vlatka Vajs

University of Belgrade

Miroslava Stanković

University of Belgrade

Cooperative Institutions

University of Belgrade

105

Institute of Chemistry, Technology and Metallurgy

Institute for Plant Protection and Environment

Institute for Technology of Nuclear and other Mineral Raw Materials

University of Novi Sad

Institut za filozofiju

Institute of Chemistry

Institut za Reumatologiju

University of Belgrade – Faculty of Chemistry

University of Kragujevac

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Composition of the Defensive Secretion in Three Species of European Millipedes

Journal of Chemical Ecology (2011)

Ljubodrag Vujisić Slobodan E. Makarov Božidar P. M. Ćurčić Bojan Ilić Vele Tešević

Chemical defense

Millipede

Benzoquinone

10.1007/s10886-011-0040-3

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Citations (16)

Blackberry Seed Extracts and Isolated Polyphenolic Compounds Showing Protective Effect on Human Lymphocytes DNA

Journal of Food Science (2011)

Dejan Gođevac Vele Tešević Vlatka Vajs Slobodan Milosavljević Miroslava Stanković

Abstract: The tentative identification of seed extracts from 3 cultivars of blackberry (blackberry seed extracts [BSEs]) constituents was performed by LC/UV/MS technique. The identified compounds belonged to ellagitannins, galic acid derivatives, and ellagic acid derivatives. Two ellagitannins, Lambertianin C and Sanguiniin H‐6, and an ellagic acid derivative, 4‐α‐L‐arabinofuranosylellagic acid, were isolated using semipreparative High‐performance liquid chromatography. The structure elucidations were based on high resolution‐mass spectrometry and nuclear magnetic resonance studies. The BSEs and 3 isolated pure compounds were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin‐B blocked micronucleus (MN) assay. The frequency of MN was scored in binucleated cells, and nuclear proliferation index was calculated. Among the tested extracts, the seeds of cv. Thornfree at concentration of 1 μg/mL exhibit the most prominent effect decreasing the frequency of MN by 62.4%, when compared with the controls cell cultures. Antioxidant potential of pure ellagitannins cannot explain the strong effect of BSEs. The assumption was that better antioxidant effect of BSEs result from synergistic effects of individual compounds contained in the extracts and/or some minor components possessed strong activity. Practical Application: Our results provide evidence of protective effects of BSEs and isolated pure compounds on cytogenetic damages in human lymphocytes. Thus, BSEs could exert beneficial effects in quite a few diseases, because many of the biological actions have been attributed to their antioxidant properties.

Ellagic Acid

10.1111/j.1750-3841.2011.02305.x

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Citations (17)

Identification of cytotoxic metabolites from Mahonia aquifolium using 1H NMR-based metabolomics approach

Journal of Pharmaceutical and Biomedical Analysis (2017)

Dejan Gođevac Ana Damjanović Tatjana Stanojković Boban Anđelković Gordana Zdunić

OPLS

10.1016/j.jpba.2017.11.075

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Citations (20)

In vitro hypoglycemic, antioxidant and antineurodegenerative activity of chokeberry (Aronia melanocarpa) leaves

Industrial Crops and Products (2020)

Gordana Zdunić Ana Alimpić Aradski Dejan Gođevac Jelena Živković Sonja Duletić‐Laušević

ABTS

Alpha-glucosidase

10.1016/j.indcrop.2020.112328

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Citations (38)

The instantaneous multi-pronged defense system of latex against general plant enemies

bioRxiv (Cold Spring Harbor Laboratory) (2020)

Luis Francisco Salomé-Abarca Dejan Gođevac Min Sun Kim Geum‐Sook Hwang Sang Cheol Park

Abstract Based on the hypothesis that variation of the metabolomes of latex is a response to selective pressure and should thus be affected differently from other organs, their variation could provide insight into the defensive chemical selection of plants. Metabolic profiling was utilized to compare tissues of Euphorbia species collected in various regions. The metabolic variation of latexes was much more limited than that of other organs. In all of the species, the levels of polyisoprenes and terpenoids were found to be much higher in latexes than in leaves and roots. Polyisoprenes were also observed to physically delay the contact and growth of pathogens with plant tissues. A secondary barrier composed of terpenes and, in particular, 24-methylenecycloartanol, exhibited antifungal activity. These results, together with the known roles of the enzymes also present in latexes, demonstrate that they are part of a cooperative defense system that comprises both biochemical and physical elements.

Terpene

Metabolic activity

10.1101/2020.06.19.161869

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GC-FID-MS Based Metabolomics to Access Plum Brandy Quality

Molecules (2021)

Stefan Ivanović Katarina Simić Vele Tešević Ljubodrag Vujisić Marko Ljekočević

Plum brandy (Slivovitz (en); Šljivovica(sr)) is an alcoholic beverage that is increasingly consumed all over the world. Its quality assessment has become of great importance. In our study, the main volatiles and aroma compounds of 108 non-aged plum brandies originating from three plum cultivars, and fermented using different conditions, were investigated. The chemical profiles obtained after two-step GC-FID-MS analysis were subjected to multivariate data analysis to reveal the peculiarity in different cultivars and fermentation process. Correlation of plum brandy chemical composition with its sensory characteristics obtained by expert commission was also performed. The utilization of PCA and OPLS-DA multivariate analysis methods on GC-FID-MS, enabled discrimination of brandy samples based on differences in plum varieties, pH of plum mash, and addition of selected yeast or enzymes during fermentation. The correlation of brandy GC-FID-MS profiles with their sensory properties was achieved by OPLS multivariate analysis. Proposed workflow confirmed the potential of GC-FID-MS in combination with multivariate data analysis that can be applied to assess the plum brandy quality.

Ethanol Fermentation

OPLS

Sensory Analysis

10.3390/molecules26051391

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Citations (17)

Structure and properties of thermoplastic polyurethanes based on poly(dimethylsiloxane): Assessment of biocompatibility

Journal of Biomedical Materials Research Part A (2013)

Marija V. Pergal Jelena Nestorov Gordana Tovilović Sanja Ostojić Dejan Gođevac

Properties and biocompatibility of a series of thermoplastic poly(urethane-siloxane)s (TPUSs) based on α,ω-dihydroxy ethoxy propyl poly(dimethylsiloxane) (PDMS) for potential biomedical application were studied. Thin films of TPUSs with a different PDMS soft segment content were characterized by 1H NMR, quantitative 13C NMR, Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), contact angle, and water absorption measurements. Different techniques (FTIR, AFM, and DMA) showed that decrease of PDMS content promotes microphase separation in TPUSs. Samples with a higher PDMS content have more hydrophobic surface and better waterproof performances, but lower degree of crystallinity. Biocompatibility of TPUSs was examined after attachment of endothelial cells to the untreated copolymer surface or surface pretreated with multicomponent protein mixture, and by using competitive protein adsorption assay. TPUSs did not exhibit any cytotoxicity toward endothelial cells, as measured by lactate dehydrogenase and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide assays. The untreated and proteins preadsorbed TPUS samples favored endothelial cells adhesion and growth, indicating good biocompatibility. All TPUSs adsorbed more albumin than fibrinogen in competitive protein adsorption experiment, which is feature regarded as beneficial for biocompatibility. The results indicate that TPUSs have good surface, thermo-mechanical, and biocompatible properties, which can be tailored for biomedical application requirements by adequate selection of the soft/hard segments ratio of the copolymers. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 3951–3964, 2014.

Biocompatibility

Protein Adsorption

10.1002/jbm.a.35071

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Citations (49)

Comparative study of the phenolic composition of seeds from grapes cv cardinal and alphonse lavallee during last month of ripening

Italian Journal of Food Science (2012)

Ana Topalović Dejan Gođevac N. Perovic Snežana Trifunović

Source

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Citations (6)

Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in rats

Phytotherapy Research (2009)

Gordana Zdunić Dejan Gođevac Marina Milenković Dragana Vučićević Katarina Šavikin

Abstract Oil extracts of Hypericum perforatum L. ( Oleum Hyperici ) were prepared in three different ways according to the prescriptions from traditional medicine. Variability of constituents and biological activity were evaluated in the obtained oil extracts. The carrageenan‐induced rat paw edema test has been used for screening the antiinflammatory activity, while the indomethacin‐induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. All examined oil extracts possessed antiinflammatory and gastroprotective activity. Among them, the oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath (extract 2), in a dose of 1.25 mL/kg p.o., exhibited the highest antiinflammatory effect (95.24 ± 11.66%) and gastroprotective activity (gastric damage score of 0.21 ± 0.12). The same oil extract had the highest content of quercetin and I3,II8‐biapigenin (129 ± 9 µg/mL and 52 ± 4 µg/mL, respectively). Quercetin and I3,II8‐biapigenin exhibited antiinflammatory activity similar to those of indomethacin as well as significant gastroprotective activity. The results provide evidence for the usage of Oleum Hyperici as an antiinflammatory and gastroprotective agent, which has been based previously only on ethnopharmacological claims. Copyright © 2009 John Wiley & Sons, Ltd.

Maceration (sewage)

Sunflower oil

Phytotherapy

10.1002/ptr.2809

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Citations (53)

Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones

European Journal of Medicinal Chemistry (2008)

Nevenka Gligorijević Tamara R. Todorović Siniša Radulović Dušan Sladić Nenad R. Filipović

HeLa

Molar conductivity

10.1016/j.ejmech.2008.07.033

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Citations (62)