Liyun Ding

Wuhan University of Technology

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Jun Huang

Macau University of Science and Technology

Jun Huang

Guangxi University

Yinquan Yuan

Wuhan University of Technology

Bing Xu

Lingnan Normal University

Desheng Jiang

Institute of Semiconductors

Jue Zhao

Lanzhou University

Yilin Tong

Wuhan College

Fei Ma

Lanzhou University

Haitao Lin

Yuxi Normal University

Ming‐Tian Li

Sichuan University of Science and Engineering

Cooperative Institutions

Wuhan University of Technology

Lanzhou University

Chinese Academy of Sciences

Huazhong University of Science and Technology

Sichuan University

University of Chinese Academy of Sciences

Eli Lilly (United States)

Lanzhou University Second Hospital

Zhejiang University

Shanghai Jiao Tong University

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A Novel L-Glutamine Binding Protein Modified Mnm Structured Optical Fiber Biosensor Based on Surface Plasmon Resonance Sensing for Detection of L-Glutamine Metabolism in Vitro Embryo Culture

Jianfeng Chen Liyun Ding Jue Zhao Xingdong Jiang Fei Ma

A novel L-glutamine-binding protein (QBP)-modified multimode-coreless-multimode (MNM) structured optical fiber biosensor based on the surface plasmon resonance (SPR) effect was developed for the detection of L-glutamine (Gln). Light generates swift waves in the coreless optical fiber portion of the MNM-structured optical fiber. A gold film was coated on the MNM structured optical fiber to excite SPR, and then QBP was modified on the surface of the gold film by cysteamine (Cys) with glutaraldehyde (GA). The modified QBP also exhibited a binding affinity for L-glutamine, and when bound to L-glutamine molecules, the conformation of QBP changed from the "open" to the "closed" state, which was manifested as a red-shift of the SPR peak on the spectrum. The dependence of the SPR peak on the concentration of L-glutamine was demonstrated in the range of 10-100 uM, with a sensitivity of 10.797nm/ log10[Gln] for L-glutamine in the in vitro embryo culture medium environment. This QBP-modified MNM structured fiber optic SPR sensor shows low fabrication cost and high sensitivity, as well as good selectivity and stability, which provides a new idea for the developmental potential assessment of embryos in the process of in vitro embryo culture.

10.2139/ssrn.4327577

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Synthesis and characterization of photorefractive polymer based on chemically hybridized CdS–PVK nanocomposite with a new azo chromophore

Polymer (2007)

Desheng Jiang Liyun Ding Jun Huang Erdan Gu Liren Liu

Chromophore

Photoconductivity

Organic photorefractive materials

Diffraction efficiency

10.1016/j.polymer.2007.09.030

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Citations (15)

Ultrasensitive NO Gas Sensor Based on the Graphene Oxide-Coated Long-Period Fiber Grating

ACS Applied Materials & Interfaces (2019)

Bing Xu Jun Huang Xiaofeng Xu Ai Zhou Liyun Ding

An ultrasensitive nitric oxide (NO) gas sensor based on the graphene oxide (GO)-coated long-period fiber grating (LPFG) was constructed successfully because of its excellent sensitivity to the surrounding refractive index (SRI) change. The surface morphology and structure of GO coated on LPFG were characterized by the scanning electron microscope (SEM), scanning probe microscope (SPM), and Raman spectroscopy, respectively. The adsorption principle of NO molecules by GO was calculated in detail by density functional theory (DFT) and further characterized by Fourier transform infrared spectrometry (FT-TR) and X-ray photoelectron spectroscopy (XPS). Our studies demonstrate that the adsorption principle of NO molecules by GO was the combined effect of physical adsorption and chemical adsorption because of the formation of C-N bonds between GO and NO and the oxidization of NO to NO2. The NO sensor exhibits excellent sensing performance in the NO concentration range of 0 to 400 ppm.

Long-period fiber grating

10.1021/acsami.9b14212

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Citations (45)

RNA-Modified Graphene Oxide-Encapsulated Gold Nanoparticles-Based Stable Fiber Optic MiRNA-126 Sensor

IEEE Sensors Journal (2023)

Bing Xu Liu Yang Liyun Ding Zhihui Luo Zhihong Pan

A stable fiber optic miRNA-126 sensor based on RNA-modified graphene oxide encapsulated gold nanoparticles was developed. Experiments and characterization showed that the detection of miRNA-126 by this sensor was based on the LSPR effect rather than the refractive index response. RNA probes 1 and 2 complementary paired with miRNA-126 bases were designed and synthesized, and the RNA probes were immobilized in GO AuNPs functionalized fiber-optic sensing probes using salt aging method. The zeta potential and colorimetric analysis of the composite nanoparticles indicated that GO improved the stability of GO-AuNPs. The fiber-optic sensor was able to quantitatively detect miRNA-126 and showed good selectivity, providing a new idea for miRNA detection.

Zeta potential

10.1109/jsen.2023.3343819

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A new immobilized glucose oxidase using SiO2 nanoparticles as carrier

Materials Science and Engineering C (2011)

Jun Huang Hai Wang Dapeng Li Wenqi Zhao Liyun Ding

Glutaraldehyde

Glucose oxidase

Thermal Stability

10.1016/j.msec.2011.05.003

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Citations (33)

A fiber grating preparation method: Drawing tower grating by single laser pulse with the phase-mask technique

Optical Fiber Technology (2022)

Huiyong Guo Man Xiang Yong Hu Guanghui He Jianguan Tang

10.1016/j.yofte.2022.102955

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Preparation of Magnetic Fluorescent Core-shell-structured Nanoparticles and Their Application in Immobilization of Glucose Oxidase

DEStech Transactions on Materials Science and Engineering (2017)

Huichao Liu Jun Huang Peipei Zhang Liyun Ding

The magnetic fluorescent core-shell structured nanoparticles, Fe3O4 @SiO2 (F) @meso-SiO2 nanoparticles (FSMSNp), with average diameter of 240 nm have been prepared and characterized. Glucose oxidase (GOD) was immobilized on them to form immobilized GOD. After immobilization, the storage stability of GOD was improved. Since the fluorescence of complex nanoparticles can be quenched by oxygen, these nanoparticles could have the potential application in multi parameter fiber optic biosensor based on enzyme catalysis and oxygen consumption.

Glucose oxidase

10.12783/dtmse/icmea2015/7320

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Controlled preparation of monodisperse CoFe2O4 nanoparticles by a facile method

Journal of Wuhan University of Technology-Mater Sci Ed (2011)

Hai Wang Jun Huang Liyun Ding Chao Wang Yun Han

Coprecipitation

Dispersity

Superparamagnetism

10.1007/s11595-011-0209-1

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