Jhon Alexander Ávila Rueda

Fundación Cardiovascular de Colombia

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Cristina Duboscq

Hospital Británico de Buenos Aires

Karla Oliveros

Fundación Cardiovascular de Colombia

Sofía Rivarola

Hospital Británico de Buenos Aires

José Ceresetto

Hospital Británico de Buenos Aires

Glenda Ernst

Hospital Británico de Buenos Aires

Hernando Mosquera Sánchez

Asociación Colombiana de Dermatología y Cirugía Dermatológica

Vanessa Torres Gómez

Universidad Autónoma de Bucaramanga

Pablo Young

Hospital Británico de Buenos Aires

Edgar Fabián Manrique-Hernández

Fundación Cardiovascular de Colombia

Julián Camilo Cala Durán

Industrial University of Santander

Cooperative Institutions

Hospital Británico de Buenos Aires

Hospital Británico

University of Boyaca

Universidad Autónoma de Bucaramanga

Fundación Cardiovascular de Colombia

Argentine Naval Hydrographic Service

Industrial University of Santander

University of Buenos Aires

Centro de Investigación Biomédica en Red

Universitat Autònoma de Barcelona

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Methods of preserving platelets: cryopreservation as a reasonable option for its implementation in Argentina

Acta Haematologica Polonica (2021)

Jhon Alexander Ávila Rueda Pablo Young Cristina Duboscq

Platelets are one of the most widely used blood components in transfusion medicine, given their importance in the prevention of bleeding disorders in patients with multifactorial thrombocytopenia and Asian non-immunological etiology, as well as in the management of traumatic or blood-related surgical treatments. Given its extensive use and the constant demand for it to be used within the different procedures associated with medicine, it is the objective of both hemotherapy services and blood banks to ensure that blood product components are constantly available to meet such requirements. The main challenge with this resource is its short useful life (5–7 days) which limits its availability, especially in the Latin American context where the production of blood components as well as the resources allocated for this purpose by state entities to blood banks, are generally limited. Cryopreservation at –80°C using dimethylsulfoxide as a preservative solution is a technique used since the 1950s to prolong platelet survival, the improvement of which has been remarkable in recent years, thereby constituting an alternative solution to this problem.

Hemotherapy

Blood product

Blood management

10.5603/ahp.2021.0032

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Uso de plasma de convaleciente en el tratamiento de paciente con neumonía por COVID-19. Reporte de caso

Revista Hematología (2020)

Jhon Alexander Ávila Rueda О. С. Рабинович Pablo Young Hernán Trimarchi Agustín Montes

Sars-Cov-2, known as COVID-19, is a virus belonging to coronavirus family, whose characteristicis the development of respiratory diseases, mainly pneumonia, with a high risk of progression to acute respiratory distress syndrome, which in turn is related to high morbidity and mortality rates that vary from case to case. Although a specific management scheme is not available, the use of convalescent plasma has been proposed as a therapeutic alternative, so studies are currently being carried out to evaluate its efficacy, although there are preliminary reports of published studies with encouraging results with low risk and possible benefits of this therapy. We present our case experience regarding the use of convalescent plasma in a 24 years old patient diagnosed with COVID-19 pneumonia at our institution.

Convalescent plasma

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Urticaria pigmentosa en el adulto

DOAJ (DOAJ: Directory of Open Access Journals) (2012)

Jhon Alexander Ávila Rueda Julián Camilo Cala Durán José A Gelvis Rodríguez Vanessa Torres Gómez Hernando Mosquera Sánchez

Urticaria pigmentosa

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Alteraciones de coagulación en los pacientes con cirrosis hepática atendidos en un hospital Universitario de Colombia

Fronteras en Medicina (2023)

Javier Orlando Barón Barón Daniela Castillo López María Fernanda Murillo Acosta I Rodríguez Diana Carolina Tovar Artunduaga

Introducción.En los estadios avanzados de la cirrosis se pueden presentar coagulopatías, las cuales se definen como los trastornos en el sistema de coagulación y se identifican por la prolongación del tiempo de protrombina, INR elevado, tiempo de tromboplastina parcial activado prolongado y trombocitopenia.El objetivo del estudio fue determinar la prevalencia de alteraciones de coagulación en los pacientes con cirrosis hepática.Materiales y métodos.Se realizó un estudio observacional, descriptivo, retrospectivo de corte transversal,

10.31954/rfem/202304/0229-0234

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Joint deficiency of coagulation factors VII and IX: a case report

Blood Coagulation & Fibrinolysis (2024)

Jhon Alexander Ávila Rueda C. de la Hoz Edgar Fabián Manrique-Hernández

The diagnostic and therapeutic approach for an unusual clinical situation is presented. Twenty-three-year-old female patient is evaluated for hematuria and metrorrhagia. She reported irregular follow-up with hematology because of bleeding in childhood. She has also been receiving factor VII for 2 years, denying hospitalizations because of bleeding. Laboratory reported hb: 5.2 g/dl; platelets: 234 000/mm 3 ; PT: 100 s; PTT: 112 s, fibrinogen: 90 mg/dl without other alterations. Abdominal ultrasound reported uterine myoma, urinalysis was pathological. The gynecology indicated oral progesterone. She started antibiotic therapy, transfusion of red-blood cells, plasma, and cryoprecipitates and subsequently reported: factor VII: 2%, IX: 1% and VIII: 70%. She received factor VII-recombinant (rFVII), achieving resolution of bleeding. She was prescribed prophylactic rFVII and hematology monitoring. Readmission due to acute abdomen with Hb 5 g/dl, prolonged prothrombin time (PT)/partial thromboplastin time (PTT) and abdominal tomography reported hemoperitoneum. She received rFVII and required laparotomy and left oophorectomy. Then readmission to metrorrhagia, hb6 g/dl, prolonged PT/PTT and factor VII-IX of two coagulation factors were reported, without reports found in the literature consulted.

Hemoperitoneum

Prothrombin time

Factor VII

Hematology

Factor IX

Metrorrhagia

10.1097/mbc.0000000000001315

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Caso clínico de urticaria pigmentosa en el adulto

Medunab (2012)

Jhon Alexander Ávila Rueda Julián Camilo Cala Durán José Agelvis Rodríguez Vanessa Torres Gómez Hernando Mosquera Sánchez

Objetivo: El objetivo de esta presentación de caso es mostrar el abordaje, seguimiento, tratamiento y medidas que se tomaron para un paciente adulto con urticaria pigmentosa, la cual es una enfermedad poco frecuente en la práctica diaria y que es un reto para el diagnóstico del médico general. Resultados y Conclusiones La urticaria pigmentosa es una de las formas más comunes de las mastocitosis, las cuales corresponden a una serie de procesos caracterizados por un aumento anormal de los mastocitos en diversos órganos y tejidos corporales. En la urticaria pigmentosa la manifestación es exclusiva de la piel, caracterizada por la presencia de lesiones maculopapulares de 2.5 a 5 mm de diámetro, de un color que puede oscilar entre rojo y café, distribuyéndose generalmente en tronco y extremidades respetando palmas y plantas, cerca de la mitad de los lesiones presenta rubor localizado, prurito y ampollas. Su incidencia y prevalencia son desconocidas sin embargo su aparición es más común en niños que en adultos. El diagnostico depende en gran manera de un adecuado examen físico complementado con estudios de laboratorio e histopatología. El tratamiento de elección constituye la administración de antihistamínicos orales. [Avila J, Cala J, Rodriguez J, Torres V.Urticaria pigmentosa. MedUNAB 2012; 15(1):63-67].

10.29375/01237047.1563

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Kimura Disease in Colombia. Case Report

Research Square (Research Square) (2024)

Jhon Alexander Ávila Rueda Edgar Fabián Manrique-Hernández Maricel Licht-Ardila Alexandra Hurtado-Ortiz Carmen Judith Suárez

Abstract Introduction: Kimura disease is a benign, chronic, and rare entity. Its etiology and pathogenesis are unclear, posing challenges for diagnosis and management. The aim is to report the case of a Colombian patient with Kimura disease. Case Report: A 68-year-old male patient with no relevant medical history presented with a 6-month history of asthenia, night sweats, and bilateral cervical lymphadenopathy. An excisional lymph node biopsy was performed, revealing atypical paracortical hyperplasia with a Ki67 proliferation index of 60% in the paracortical region and 100% in residual germinal centers, suggesting a reactive process consistent with Kimura disease. Discussion: This case highlights the importance of considering Kimura disease as a differential diagnosis in patients with symptoms consistent with this condition.

Kimura's disease

10.21203/rs.3.rs-4076773/v1

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Evaluation of survival and functionality in frozen platelets

Hematology Transfusion and Cell Therapy (2023)

Jhon Alexander Ávila Rueda José Antonio Lorente Acosta Oscar Rabinovich José Ceresetto Glenda Ernst

Prolong platelet survival and functionality up to 28 days. A sample of apheresis platelets was evaluated, distributed in 3 groups according to the cryopreservative solution used: DMSO5%+2%albumin; DMSO5%+NaCl0,9% and DMSO5%+Dextrose2%. They were then frozen at -80 °C and thawed at 7, 14 and 28 days. The in vitro survival and viability were assessed by the post-thaw platelet count and the CD41, CD61 and CD42a staining percentages by flow cytometry. The functionality was determined with the percentage of post-stimulation aggregation with 1Nm-thrombin using the Chromo-Log490 aggregometer. The control group (CG) consisted of fresh platelets under constant agitation at 22 °C. A total of 72 platelet aliquots was analyzed. The CG presented a platelet-count of 1934 ± 0.5 × 109/L and a 100% viability. The percentages of CD41, CD61 and CD42a labeling were 99, 98.5 and 96.5%, respectively. The percentage of aggregation was 99%. On day 7 of the post-freezing, the platelet count for groups 1, 2 and 3 was 1,844 ± 102, 1,856 ± 76 and 1,752 ± 226, with the viability of 98, 96 and 95%, respectively. On day 14, the counts were 1,722 ± 238, 1,649 ± 215 and 1,578 ± 223 with the viability of 96, 95 and 94% and, on day 28, they were 1,602 ± 374, 1,438.6 ± 429 and 1,406.6 ± 436, with the viability of 96, 94 and 93%, respectively. Group1 presented a higher expression of membrane antigens. Aggregation percentages were 90, 98 and 89% at day 7, 88%, 98 and 87% at day 14 and 84%, 95 and 82% at day of the 28 post-freezing, respectively, with group2 presenting the best results. The results support cryopreservation as a reasonable method to prolong platelet survival up to 28 days, maintaining its functionality and viability greater than 50%.

10.1016/j.htct.2023.01.002

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Manejo de náuseas y vómitos inducidos por quimioterapia en pacientes hematológicos

Universitas Médica (2021)

Jhon Alexander Ávila Rueda Nicolás Flegler Karla Oliveros Sofía Rivarola Agustín Montes Onganía

Las náuseas y vómitos (NyV) constituyen dos de los efectos adversos frecuentemente asociados a la administración de quimioterapia además de otros fármacos empleados en hematología. La importancia que la prevención y el manejo de estos síntomas tiene en nuestros pacientes, radica en los riesgos que representan cuando no son tratados correctamente como por ejemplo: deshidratación, alteraciones hidroelectrolíticas e insuficiencia renal aguda. Para la elaboración este artículo se realizó una revisión de la literatura en función de la evidencia y esquemas disponibles para la prevención y tratamiento de NV inducido por medicamentos usados en el manejo de pacientes con patologías hematológicas.

10.11144/javeriana.umed62-3.mnvi

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Thallium poisoning: a case report

Journal of Yeungnam Medical Science (2022)

Óscar Romera Jiménez Héctor Cáceres Luis Giménez Luciana Soto Micaela Montenegro

Thallium poisoning is usually accidental. We present a case of a 51-year-old woman who was evaluated in June 2018 for myalgia, vertigo, asthenia, and abdominal pain. Physical examination revealed temporal-spatial disorientation, jaundice, and asterixis. The laboratory reported the following: bilirubin, 10.3 mg/dL; aspartate transaminase, 78 U/L; alanine transaminase, 194 U/L; albumin, 2.3 g/dL; prothrombin time, 40%; and platelet count, 60,000/mm3. Serology performed for hepatitis A, B, and C; Epstein-Barr virus; cytomegalovirus; and human immunodeficiency virus was negative, and a collagenogram was negative. Physical reevaluation revealed alopecia on the scalp, armpits, and eyebrows; macules on the face; plantar hyperkeratosis; and ulcers on the lower limbs. Tests for lead, arsenic, copper, and mercury were carried out, which were normal; however, elevated urinary thallium (540 µg/g; range, 0.4–10 µg/g) was observed. The patient was treated with D-penicillamine 1,000 mg/day and recovered her urinary thallium levels were within normal range at annual follow-up. Thallium poisoning is extremely rare and can be fatal in small doses. An adequate clinical approach can facilitate early diagnosis. Keywords: Alopecia; Intoxication; Liver failure; Thallium

Thallium

myalgia

Toxic hepatitis

Aspartate transaminase

10.12701/jyms.2022.00647

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