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Álvaro Alvarez

Universidad de Montevideo

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Jerzy Trojan

Inserm

Ignacio Briceño

Universidad de La Sabana

Annabelle Trojan

University of Cartagena

Heliodor Kasprzak

Nicolaus Copernicus University

Antonio Martínez Illán

Universidad de Navarra

Alexander Shevelev

Institute of Experimental Cardiology

Huynh Thien Duc

Hôpital Paul-Brousse

Maria Claudia Noguera

Universidad de La Sabana

Pedro Penagos

National Cancer Institute

Heber O. Siachoque

Cooperative Institutions

University of Cartagena

Inserm

Université Paris-Saclay

Hôpital Paul-Brousse

Universitat Politècnica de Catalunya

Centre National de la Recherche Scientifique

Universidad Nacional Autónoma de México

Université Paris Cité

University of the Basque Country

Universidad de Antioquia

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A Reliable Turning Process by the Early Use of a Deep Simulation Model at Several Manufacturing Stages

Gorka Urbikaín Luís Norberto López de Lacalle Mikel Arsuaga Álvaro Alvarez Miguel A. Alonso

The future of machine tools will be dominated by highly flexible and interconnected systems, in order to achieve the required productivity, accuracy and reliability. Nowadays, distortion and vibration problems are easily solved in labs for the most common machining operations by using models based on equations describing the physical laws of the machining processes; however additional efforts are needed to overcome the gap between scientific research and the real manufacturing problems. In fact, there is an increasing interest in developing simulation packages based on “deep-knowledge and models” that aid machine designers, production engineers or machinists to get the best of the machine-tools. This article proposes a methodology to reduce problems in machining by means of a simulation utility, which uses the main variables of the system&process as input data, and generates results that help in the proper decision-making and machining planification. Direct benefits can be found in a) the fixture/clamping optimal design, b) the machine tool configuration, c) the definition of chatter-free optimum cutting conditions and d) the right programming of cutting toolpaths at the Computer Aided Manufacturing (CAM) stage. The information and knowledge-based approach showed successful results in several local manufacturing companies and are explained in the paper.

Fixture

Machine tool

10.20944/preprints201703.0196.v1

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Neoplastic Brain, Glioblastoma, and Immunotherapy

IntechOpen eBooks (2020)

Annabelle Trojan Heliodor Kasprzak Óscar Gutiérrez Pedro Penagos Ignacio Briceño

IGF-I, insulin-like growth factor 1, is present in normal fetal/neonatal brain development and reappears in the mature brain participating in the development of malignant tumor, glioblastoma multiforme. Targeting the IGF-I system has emerged as a useful method to reduce glial malignant development. Downregulation in the expression of IGF-I using antigene anti-IGF-I technology (antisense, AS, and triple helix, TH) applied in glioma cell culture established from glioblastoma biopsies induces the expression of B7 and MHC-I antigens in transfected cells (immunogenicity). The transfected cancer cells, "vaccines," after subcutaneous injection, initiated an immune response mediated by T CD8+ lymphocytes, followed by tumor regression (immunotherapy). The median survival of patients treated by surgery followed by radiotherapy and immunotherapy was 21–24 months. On the other side, the experimental work has demonstrated that IGF-I AS or TH transfected tumor cells fused with activated dendritic cells, DC, showing more striking immunogenic character. Using IGF-I TH/DC "vaccination," the efficiency in suppressing rat glioma tumors is not only relatively higher than that obtained using IGF-I TH cells but is also more rapid.

Brain tumor

10.5772/intechopen.84726

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COMPARTEN LOS VETERINARIOS EL COMPROMISO DE MEJORAR LA ALIMENTACION DE LA SOCIEDAD

Gaceta UNAM (1990-1999) (1995)

Laura Romero Leopoldo Paasch Álvaro Alvarez Igor Romero Sosa

EN LA CEREMONIA DE CELEBRACION DEL DECIMO ANIVERSARIO DE LA GENERACION 1981-1985 MAESTRA MARIA INES IZAGUIRRE ROMERO DE LA FACULTAD DE MEDICINA VETERINARIA Y ZOOTECNIA (FMVYZ), EL DIRECTOR DE ESTA DEPENDENCIA, DOCTOR LEOPOLDO PAASCH MARTINEZ, INVITO AL GRUPO DE EGRESADOS A INTERRELACIONARSE CON LA INSTITUCION QUE LOS FORMO, A TRAVES DE LA DIVISION DE EDUCACION CONTINUA, ASI COMO CON EL USO DE LOS SERVICIOS AUTOMATIZADOS DE LA BIBLIOTECA DE LA DEPENDENCIA, QUE POSEE EL BANCO DE DATOS MAS GRANDE DE LA ESPECIALIDAD EN MEXICO. A NOMBRE DE LOS EGRESADOS HABLO ALVARO ALVAREZ BARRAGAN. EN EL EVENTO, SE DEVELO UNA PLACA CONMEMORATIVA DE DICHO ANIVERSARIO.

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Methodology for Anti-Gene Anti-IGF-I Therapy of Malignant Tumours

Chemotherapy Research and Practice (2012)

Jerzy Trojan Yuexin Pan Ming Wei Adama Ly Alexander Shevelev

The aim of this study was to establish the criteria for methodology of cellular "anti-IGF-I" therapy of malignant tumours and particularly for glioblastoma multiforme. The treatment of primary glioblastoma patients using surgery, radiotherapy, and chemotherapy was followed by subcutaneous injection of autologous cancer cells transfected by IGF-I antisense/triple helix expression vectors. The prepared cell "vaccines" should it be in the case of glioblastomas or other tumours, have shown a change of phenotype, the absence of IGF-I protein, and expression of MHC-I and B7. The peripheral blood lymphocytes, PBL cells, removed after each of two successive vaccinations, have demonstrated for all the types of tumour tested an increasing level of CD8(+) and CD8(+)28(+) molecules and a switch from CD8(+)11b(+) to CD8(+)11. All cancer patients were supervised for up to 19 months, the period corresponding to minimum survival of glioblastoma patients. The obtained results have permitted to specify the common criteria for "anti-IGF-I" strategy: characteristics sine qua non of injected "vaccines" (cloned cells IGF-I(-) and MHC-I(+)) and of PBL cells (CD8(+) increased level).

10.1155/2012/721873

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Manuel Chaves Nogales, periodista

Anagramas - Rumbos y sentidos de la comunicación (2013)

Álvaro Alvarez

Este artículo muestra las ideas clave de Manuel Chaves Nogales (Sevilla, 1897– Londres, 1944) sobre el periodismo. Para ello, se han recogido los textos queescribió hablando de la profesión. Chaves Nogales fue uno de los periodistasmás destacados de la II República española. Subdirector del moderado diarioAhora, el de mayor éxito en aquella época, se tuvo que exiliar primero a París, acausa de la Guerra Civil, y después a Londres, tras la entrada de la Alemania nazien Francia. Su carácter mesurado, inequívocamente democrático y republicano,alejado de los extremos del fascismo y el comunismo, el propio de un "pequeñoburgués liberal", como él mismo se definía, propiciaron su olvido duranteaños. Solo en los últimos tiempos su obra, ejemplo de periodismo moderno,se está empezando a reeditar en España, con gran éxito de crítica y lectores

10.22395/angr.v11n22a7

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21266. APLICACIÓN DE LA BATERÍA NEUROPSICOLÓGICA DEL PROYECTO NEURONORMA EN PACIENTES CON DEMENCIA POR CUERPOS DE LEWY

Neurology Perspectives (2024)

J.L. Carbonero M. Valles Salgado Álvaro Alvarez Cristina Alonso M. Díez Cirarda

10.1016/s2667-0496(24)01112-8

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CHAVES NOGALES, Manuel (2011): "Lo que ha quedado del imperio de los zares". Sevilla, Editorial Renacimiento, 347 páginas.

Estudios sobre el Mensaje Periodístico (2012)

Álvaro Alvarez

10.5209/rev_esmp.2012.v18.n1.39558

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Glioblastoma - Application of Gene Therapy During A Quarter of A Century: Anti - Gene IGF-I Strategy

Acta Scientific Cancer Biology (2019)

Gabriela Quintero Andrea Guzman Diana Marcela Rojas Gómez Heliodor Kasprzak Pedro Penagos

Quarter (Canadian coin)

10.31080/ascb.2020.04.glioblastoma-application-of-gene-therapy-during-a-quarter-of-a-century-anti-gene-igf-i-strategy

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Manuel Chaves Nogales y el nuevo periodismo

DOAJ (DOAJ: Directory of Open Access Journals) (2013)

Álvaro Alvarez

Resumen es: Esta investigacion pretende mostrar las tecnicas y los usos periodisticos que han llevado a diferentes periodistas y escritores espanoles a considerar a ...

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El arte del retrato en los textos periodísticos de Manuel Chaves Nogales

Zer - Revista de Estudios de Comunicación (2016)

Álvaro Alvarez Antonio Martínez Illán

Este artículo estudia el arte de la caracterización del periodista Manuel Chaves Nogales (Sevilla,1897 – Madrid, 1944) en una selección de sus textos periodísticos publicados en España. Se trata de 18 piezas de diferentes géneros (crónicas, semblanzas, reportajes, entrevistas) en los que la caracterización es elemento central. A través de ellos se puede observar la evolución en la caracterización de Chaves y su afán por desvelar el carácter de personajes de actualidad a través de escenas significativas, mediante unas pocas pinceladas que, indirectamente, muestran sus preocupaciones políticas, sociales y periodísticas.

10.1387/zer.16426

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