Kimia Fazeli

Zahedan University of Medical Sciences

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Saeedeh Salimi

Zahedan University of Medical Sciences

Azam Hajizadeh

National Institute of Genetic Engineering and Biotechnology

Maryam Khodamian

Zahedan University of Medical Sciences

Minoo Yaghmaei

Shahid Beheshti University of Medical Sciences

Atefeh Pejman

Zahedan University of Medical Sciences

Mojtaba Mousavi Bazaz

Mashhad University of Medical Sciences

Anoosh Naghavi

Zahedan University of Medical Sciences

Marzieh Ghasemi

Zahedan University of Medical Sciences

Narjes Keikha

Sina Hospital

F Fazeli

Birjand University of Medical Sciences

Cooperative Institutions

Zahedan University of Medical Sciences

Shahid Beheshti University of Medical Sciences

Tehran University of Medical Sciences

Isfahan University of Medical Sciences

Sina Hospital

Shahid Beheshti University

University of Isfahan

Kerman University of Medical Sciences

National Institute of Genetic Engineering and Biotechnology

Mashhad University of Medical Sciences

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An association study of polymorphisms in the H19 imprinted gene in an Iranian population with the risk of polycystic ovary syndrome

Biology of Reproduction (2020)

Marzieh Ghasemi Milad Heidari Nia Mohammad Hashemi Narjes Keikha Kimia Fazeli

Abstract Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies that causes problems in female fertility at the reproductive age. PCOS is a multifactorial disease, with genetic factors playing a crucial role in its development. H19 is a long non-coding RNA (lncRNA) expressed from the maternal chromosome, which is correlated with PCOS. In this study, 115 women suffering from PCOS and 130 healthy women with regular menstrual cycles were recruited as case and control groups, respectively. After the extraction of genomic DNA, the restriction fragment length polymorphism polymerase chain reaction was employed for genotyping of rs2067051G>A and rs3741219T>C. Statistical analysis was done using SPSS package V.22 for Windows. In silico analysis was recruited to determine the effects of SNPs on the secondary structure of gene transcript as well as miRNA binding sites. The obtained data showed that the A allele of rs2067051G>A was associated with the high risk of PCOS (OR = 2.00, 95%CI = 1.38–2.91, P = 0.00). AG and AA genotypes led to a 3.64- and (about) a five-fold increase in the risk of PCOS, respectively (95%CI = 2.02–6.54, P = 0.00, and 95%CI = 1.51–16.52, P = 0.00, respectively). These variants caused a significant increase in the risk of this disorder in all genotype models except in the recessive model. However, no association was found between rs3741219T>C and the increased risk of PCOS, either in the allele or in the genotype models. According to the findings, rs2067051G>A is associated with an increased risk of PCOS in the Iranian population.

Genomic Imprinting

10.1093/biolre/ioaa131

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Association between Body Mass Index and frequency and grade of varicocele in southeast Iran.

PubMed (2015)

F Fazeli Mansour Shahraki Mojtaba Mousavi Bazaz Kimia Fazeli

Background: Varicocele is associated with impaired spermatogenesis. It may also be associated with the patients' weight. We aimed to determine the relationship between body mass index (BMI) and the frequency and grade of varicocele among a sample of Iranian men in southeast Iran. Methods: This cross-sectional study was conducted during 2010 and 2011 among 167 men who referred to the University affiliated Urology Clinics in Zahedan, Iran. Expert urologists examined the patients for the existence of varicocele and determined its grade as I to III. The age, grade of varicocele, and the side of varicocele as well as the weight and height of the patients were measured and recorded. The patients were categorized in different age groups. Data were analyzed by using SPSS software. Results: The patients' mean age was 27.9 ± 7.6 years and their mean BMI was 23.5 ± 4.7 kg/ m2. Varicocele was more frequent in the age group of 20-30 years. Most patients had grade II varicocele without a significant difference between the age groups (P=0.11). The mean BMI of patients with right varicocele was not different from those with left varicocele (P=0.34). The BMI of patients with bilateral varicocele was not different with those having right (P=0.94) and left (P=0.17) varicocele. 17.9%, 56.5%, and 25.6% of the patients had varicocele grade I, II, and III, respectively. Conclusions: In patients with lower BMI, the testicular vein may have a higher grade of varicocele. Urologists should consider examining young, tall men to detect various grades of varicocele as a part of their physical examination.

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Evaluating International Prostate Symptom Score (IPSS) in Accuracy for Predicting Post-Operative Urinary Retention After Elective Cataract Surgery: A Prospective Study

Global Journal of Health Science (2015)

Faramarz Fazeli Shahram Gooran Majidreza Erfanian Taghvaei Kimia Fazeli

Background: Postoperative urinary retention-a common and important complication of surgical procedures, can occur after any form of surgical intervention, in both sexes and all ages regardless of patients' previous history of urinary problems. The importance of post operative urinary tract retention is due to its effect on development of post operative urinary infection, patient anxiety and discomfort, prolongation of hospital stay and increase in hospital costs and morbidity. The International Prostate Symptom Score (IPSS) is an easy method for quantifying and estimating the association between pre-operative bladder-outflow problems and post-operative urinary retention. The aim of present study was to investigate whether the IPSS could predict the likelihood of patients developing urinary retention after elective cataract surgery. Methods: One hundred and fourteen male patients older than fifty years old, who were candidate for elective cataract surgery, were enrolled in this study. All patients completed an IPSS questionnaire form before operation, and classified into three groups regarding their score (0-7: mild, 8-19: moderate, 20- 35: severe). Results: Totally 8 patients (7%) developed post-operative urinary retention during first 24 hours after operation. Of the 8 urinary retention patients, 2 had moderate symptoms and 6had severe symptoms. There was a significant difference in developing postoperative urinary retention between patients having mild symptoms and patients having severe symptoms (P-value: 0.025). Conclusion: It is concluded that while some litterateurs definitely support the idea that IPSS may be useful for predicting post operative urinary retention, there are still some controversies. Considering our results, it seems that IPSS score is not useful in the accurate prediction of those patients who are likely to develop postoperative retention after surgical procedures other than arthroplasty, and more precise studies are need to be conducted about urinary retention occurring postoperatively in different type surgeries, different methods of anesthesia considering age and gender of patients.

Urinary retention

10.5539/gjhs.v7n7p93

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Using Internet of Things and biosensors technology for health applications

IET Wireless Sensor Systems (2018)

H. Hamidi Kimia Fazeli

10.1049/iet-wss.2017.0129

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Association of polymorphisms and haplotypes in the cytochrome P450 1B1 gene with uterine leiomyoma: A case control study

Biomedical Reports (2014)

Saeedeh Salimi Maryam Khodamian Mehrnaz Narooie-Nejad Azam Hajizadeh Kimia Fazeli

Uterine leiomyoma (UL) is an estrogen-dependent neoplasm of the uterus and estrogen metabolizing enzymes affect its promotion and progression. The aim of the present study was to evaluate the association between four single-nucleotide polymorphisms (SNPs) of the cytochrome P450 1B1 (CYP1B1) gene and UL risk. Four SNPs of the CYP1B1 gene in 105 UL patients and 112 unrelated healthy controls were genotyped using a direct sequencing method. Haplotype analyses were performed with UNPHASED software and linkage disequilibrium (LD) was assessed by Haploview software. There were no associations between Leu432Val (rs1056836), Asp449Asp (rs1056837) and Asn453Ser (rs1800440) polymorphisms of the CYP1B1 gene and UL. Although the genotypic frequencies of the Arg368His (rs79204362) polymorphism did not differ between the two groups, the frequency of A (His) allele was significantly higher in UL females (P=0.02). In addition, the frequency of GTAA haplotype was significantly higher in the controls and played a protective role in UL susceptibility. A strong LD between the three common SNPs (rs1056836, rs1056837 and rs1800440) in the CYP1B1 gene was observed in the population. In conclusion, a higher frequency of the CYP1B1 368His (A) allele was observed in UL females. The frequency of the GTAA haplotype was significantly higher in healthy females and this haplotype played a protective role in UL susceptibility.

Linkage Disequilibrium

CYP1B1

Genetic Association

Minor allele frequency

SNP

10.3892/br.2014.413

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Age-dependent association of MDM2 promoter polymorphisms and uterine leiomyoma in South-East Iran: A preliminary report

Journal of Obstetrics and Gynaecology Research (2014)

Saeedeh Salimi Azam Hajizadeh Maryam Khodamian Atefeh Pejman Kimia Fazeli

Abstract Aim Murine double minute clone 2 ( MDM2 ) is an important regulator of p53 tumor suppressor protein. Because increased MDM2 expression has been observed in different tumors, its polymorphisms are proposed to be associated with accelerated tumor formation. The aim of this study was to examine the association between T309G (rs2279744) and 40‐bp Insertion/deletion (rs3730485) polymorphisms of the MDM2 gene and risk of uterine leiomyoma ( UL ). Methods We analyzed the MDM2 gene polymorphisms of 154 UL patients and 197 healthy controls by polymerase chain reaction ( PCR ) or PCR restriction fragment length polymorphism ( RFLP ) methods. Results The frequency of MDM2 T309G polymorphism genotypes was not different between UL women and controls. Although there was an association between MDM2 40‐bp del/del genotype and UL before and after adjustment for age, the association between Insertion/deletion (Indel) genotype and UL was significant after adjustment for age. Conclusion MDM2 T309G polymorphism was not associated with UL and MDM2 40‐bp Indel polymorphism could be an age‐related risk factor for UL .

Uterine Leiomyoma

Association (psychology)

10.1111/jog.12625

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Citations (16)