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Àngels Fabra

Bellvitge University Hospital

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Amparo Cano

Instituto de Investigaciones Biomédicas Sols-Morreale

Antònia Vinyals

Duran i Reynals Hospital

Gema Moreno‐Bueno

Instituto de Salud Carlos III

David Olmeda

Spanish National Cancer Research Centre

Joaquim Marcoval

Universitat de Barcelona

Francisco Portillo

Universidad Autónoma de Madrid

Àngels Sierra

Institut d'Investigació Biomédica de Bellvitge

J.R. Ferreres

Institut d'Investigació Biomédica de Bellvitge

Esther Bertrán

Institut d'Investigació Biomédica de Bellvitge

Juana M. Flores

Memorial Sloan Kettering Cancer Center

Cooperative Institutions

Universitat de Barcelona

Institut d'Investigació Biomédica de Bellvitge

Bellvitge University Hospital

Instituto de Salud Carlos III

Institut Català d'Oncologia

Universitat Autònoma de Barcelona

Duran i Reynals Hospital

Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

Consejo Superior de Investigaciones Científicas

Centro de Investigación Biomédica en Red

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Supplementary Methods and Materials from SNAI1 Is Required for Tumor Growth and Lymph Node Metastasis of Human Breast Carcinoma MDA-MB-231 Cells

David Olmeda Gema Moreno‐Bueno Juana M. Flores Àngels Fabra Francisco Portillo

Supplementary Methods and Materials from SNAI1 Is Required for Tumor Growth and Lymph Node Metastasis of Human Breast Carcinoma MDA-MB-231 Cells

Breast carcinoma

SNAI1

Breast tumor

10.1158/0008-5472.22370870.v1

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Supplementary Methods and Materials from SNAI1 Is Required for Tumor Growth and Lymph Node Metastasis of Human Breast Carcinoma MDA-MB-231 Cells

David Olmeda Gema Moreno‐Bueno Juana M. Flores Àngels Fabra Francisco Portillo

Supplementary Methods and Materials from SNAI1 Is Required for Tumor Growth and Lymph Node Metastasis of Human Breast Carcinoma MDA-MB-231 Cells

Breast carcinoma

SNAI1

Breast tumor

10.1158/0008-5472.22370870

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AURKA Overexpression Is Driven by FOXM1 and MAPK/ERK Activation in Melanoma Cells Harboring BRAF or NRAS Mutations: Impact on Melanoma Prognosis and Therapy

Journal of Investigative Dermatology (2017)

Joan Antón Puig-Butillé Antònia Vinyals J.R. Ferreres Paula Aguilera Eduard Cabré

FOXM1

10.1016/j.jid.2017.01.021

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Supplementary Figure 3 from SNAI1 Is Required for Tumor Growth and Lymph Node Metastasis of Human Breast Carcinoma MDA-MB-231 Cells

David Olmeda Gema Moreno‐Bueno Juana M. Flores Àngels Fabra Francisco García‐del Portillo

Supplementary Figure 3 from SNAI1 Is Required for Tumor Growth and Lymph Node Metastasis of Human Breast Carcinoma MDA-MB-231 Cells

Breast carcinoma

SNAI1

Breast tumor

10.1158/0008-5472.22370882.v1

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Transforming Growth Factor β1Induces Squamous Carcinoma Cell Variants with Increased Metastatic Abilities and a Disorganized Cytoskeleton

Experimental Cell Research (1998)

Pilar Frontelo M Gonzalez-Garrigues Senén Vilaró Carlos Gamallo Àngels Fabra

10.1006/excr.1998.4219

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Citations (31)

351 Fibrinolytic pattern of human umbilical vein endothelial cells (HUVEC) in early cultures

Fibrinolysis and Proteolysis (1988)

C.J. Chanquía J. Fontcuberta Àngels Fabra Miquel Rutllant

10.1016/0268-9499(88)90698-4

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The utility of ancillary tests in monitoring cutaneous melanoma patients to detect visceral metastasis

Journal of the European Academy of Dermatology and Venereology (2014)

J.R. Ferreres Joaquim Marcoval K. Fodge María Ochoa de Olza A. Viñals

10.1111/jdv.12602

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Intravascular injections of a conditional replicative adenovirus (adl118) prevent metastatic disease in human breast carcinoma xenografts

Gene Therapy (2001)

Àngels Fabra Carlos Amílcar Parada Antònia Vinyals Pilar Martín‐Duque Verónica Fernández

Breast carcinoma

Primary tumor

Adenovirus infection

10.1038/sj.gt.3301567

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Citations (11)

Estudio micologico en pacientes con sindrome de inmunodeficiencia adquirida

Archivos del Hospital Vargas (1995)

M. Isabel Arranz Peña Hélène Moron H Marfil Johann Fernando Orozco Castro Laura Contreras

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Adenovirus E1A orchestrates the urokinase-plasminogen activator system and upregulates PAI-2 expression, supporting a tumor suppressor effect

International Journal of Oncology (2006)

V. Fernández‐Soria Matilde E. Lleonart María Díaz-Fuertes Raquel Villuendas Ricardo Sánchez‐Prieto

Invasiveness and metastatic potential are the two most important properties defining malignancy. The adeno-virus E1A (Ad-E1A) gene has a dual effect as a proliferative gene and as a tumor-suppressor gene, decreasing tumor growth and the metastatic potential of malignant cells. In order to study genes related with the antimetastatic effect of Ad-E1A in human cells, we performed a microarray analysis using OncoChiptrade mark. In three independent experiments, NIH3T3, IMR90 and MDA MB 435 cells were infected with pLPC retroviruses carrying the adenovirus 12S E1A gene or the GFP gene. We analyzed cDNA expression by using the CNIO OncoChipTM, a cDNA microarray containing a total of 6386 genes represented by 7237 clones. uPA, uPAr, tPA, PAI-1 and PAI-2 were also studied at RNA and protein levels. Microarrays of cDNA expression, RT-PCR and Western blot performed in IMR90 E1A-expressing cells showed downregulation of uPA, uPAr, tPA, PAI-1 and upregulation of PAI-2. These results were confirmed in NIH3T3 and MDA MB 435 breast carcinoma cells, with PAI-2 upregulation by RT-PCR and Western blot. In addition, zymographic analysis demonstrated that E1A expression greatly reduced the gelatinase activity of the pro-MMP2 and -MMP9 proteins. We propose that adenovirus E1A may orchestrate the expression of most members of the urokinase-plasminogen activation system, downregulating potentially invasive genes and upregulating PAI-2, which is associated with a better prognosis in human tumors.

10.3892/ijo.28.1.143

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Citations (11)

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