Ou Dai

Chengdu University of Traditional Chinese Medicine

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Cheng Peng

First Affiliated Hospital of Jinan University

Liang Xiong

Chengdu University of Traditional Chinese Medicine

Qin‐Mei Zhou

Chengdu University of Traditional Chinese Medicine

Chun‐Wang Meng

Chengdu University of Traditional Chinese Medicine

Li Guo

Sichuan University

Hai‐Guo Su

Chengdu University of Traditional Chinese Medicine

Jing Zuo

Chengdu University of Traditional Chinese Medicine

Xiaofang Xie

Sichuan University

Chengjun He

Xihua University

Hong‐Zhen Shu

Chengdu University of Traditional Chinese Medicine

Cooperative Institutions

Chengdu University of Traditional Chinese Medicine

Chinese Academy of Sciences

Sichuan University

Chinese Academy of Medical Sciences & Peking Union Medical College

Sichuan Agricultural University

Huazhong University of Science and Technology

Nanjing Medical University

Ministry of Agriculture and Rural Affairs

Chinese Academy of Agricultural Sciences

Peking University

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Five New Bisabolane-Type Sesquiterpenoids with Oxygen-Containing Heterocyclic Systems from Curcuma Longa

Ou Dai Guang-Xu Wu Hong‐Zhen Shu Cheng Peng Fei Liu

10.2139/ssrn.5025213

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Antiproliferative and Proapoptotic Effects of Phenanthrene Derivatives Isolated from Bletilla striata on A549 Lung Cancer Cells

Molecules (2022)

Fei Zhou Rui Feng Ou Dai Lian Yang Yu Liu

Lung cancer continues to be the world's leading cause of cancer death and the treatment of non-small cell lung cancer (NSCLC) has attracted much attention. The tubers of Bletilla striata are regarded as "an excellent medicine for lung diseases" and as the first choice to treat several lung diseases. In this study, seventeen phenanthrene derivatives, including two new compounds (1 and 2), were isolated from the tubers of B. striata. Most compounds showed cytotoxicity against A549 cells. An EdU proliferation assay, a cell cycle assay, a wound healing assay, a transwell migration assay, a flow cytometry assay, and a western blot assay were performed to further investigate the effect of compound 1 on A549 cells. The results showed that compound 1 inhibited cell proliferation and migration and promoted cell apoptosis in A549 cells. The mechanisms might correlate with the regulation of the Akt, MEK/ERK, and Bcl-2/Bax signaling pathways. These results suggested that the phenanthrenes of B. striata might be important and effective substances in the treatment of NSCLC.

MTT assay

10.3390/molecules27113519

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Pro-Angiogenic Effects of Essential Oil from Perilla frutescens and Its Main Component (Perillaldehyde) on Zebrafish Embryos and Human Umbilical Vein Endothelial Cells

Drug Design Development and Therapy (2021)

Fei Zhou Ou Dai Cheng Peng Liang Xiong Hui Ao

Perilla frutescens (L.) Britt., a traditional edible-medicinal herb in China, has been used to treat cardiovascular and cerebrovascular (cardio-cerebrovascular) diseases for thousands of years. However, knowledge of the mechanisms underlying the effects of essential oil from P. frutescens (EOPF) in the treatment of cardio-cerebrovascular diseases is lacking. The promotion of angiogenesis is beneficial in the treatment of ischemic cardio-cerebrovascular diseases. The current study investigated the pro-angiogenic role of EOPF and its main component perillaldehyde in sunitinib-injured transgenic Tg (flk1:EGFP) zebrafish embryos and human umbilical vein endothelial cells (HUVECs) for the first time.The pro-angiogenic effects of EOPF and perillaldehyde were observed in vivo using transgenic Tg (flk1:EGFP) zebrafish embryos and in vitro using HUVECs. Cell viability, proliferation, migration, tube formation, and protein levels were detected by MTT, EdU staining, wound healing, transwell chamber, and Western blot assays, respectively.EOPF and perillaldehyde exerted a significant stimulatory effect on the formation of zebrafish intersegmental vessels (ISVs). Moreover, EOPF and perillaldehyde promoted proliferation, migration, and tube formation in sunitinib-treated HUVECs. Additionally, our findings uncovered that the pro-angiogenic effects of EOPF and perillaldehyde were mediated by increases in the expression ratios of p-ERK1/2 to ERK1/2 and Bcl-2 to Bax.The present study is the first report to provide clear evidence that EOPF and perillaldehyde promote angiogenesis by stimulating repair of sunitinib-injured ISVs in zebrafish embryos and promoting proliferation, migration, and tube formation in sunitinib-injured HUVECs. The underlying mechanisms are related to increased p-ERK1/2 to ERK1/2 and Bcl-2 to Bax expression ratios. EOPF and perillaldehyde may be used in the treatment of cardio-cerebrovascular diseases, which is consistent with the traditional application of P. frutescens.

Perilla frutescens

Hibiscus Sabdariffa

10.2147/dddt.s336826

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Traditional Chinese medicine formulas, extracts, and compounds promote angiogenesis

Biomedicine & Pharmacotherapy (2020)

Lan Bu Ou Dai Fei Zhou Fei Liu Jinfeng Chen

Ischemic diseases, such as ischemic heart diseases and ischemic stroke, are the leading cause of death worldwide. Angiogenic therapy is a wide-ranging approach to fighting ischemic diseases. However, compared with anti-angiogenesis therapy for tumors, less attention has been paid to therapeutic angiogenesis. Recently, Traditional Chinese medicine (TCM) has garnered increasing interest for its definite curative effect and low toxicity. A growing number of studies have reported that TCM formulas, extracts, and compounds from herbal medicines exert pro-angiogenic activity, which has been confirmed in a few clinical trials. For comprehensive analysis of relevant literature, global and local databases including PubMed, Web of Science, and China National Knowledge Infrastructure were searched using keywords such as "angiogenesis," "neovascularization," "traditional Chinese medicine," "formula," "extract," and "compound." Articles were chosen that are closely and directly related to pro-angiogenesis. This review summarizes the pro-angiogenic activity and the mechanism of TCM formulas, extracts, and compounds; it delivers an in-depth understanding of the relationship between TCM and pro-angiogenesis and will provide new ideas for clinical practice.

10.1016/j.biopha.2020.110855

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Citations (92)

Four pairs of enantiomeric phenanthrenes from the tubers of Bletilla striata and their cytotoxicity in A549 lung cancer cells

Journal of Molecular Structure (2024)

Ou Dai Chen-Hao Liu Fang Wang Chun‐Wang Meng Li-Man Niu

Phenanthrenes

10.1016/j.molstruc.2024.140917

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Effects of Angelica Oil and the Isolated Butylphthalides on Glutamate-induced Neurotoxicity in PC12 Cells

Lu-Si Liu Cheng Peng Qin‐Mei Zhou Liang Xiong Li Guo

Neurotoxicity

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Study on chemical constituents of seeds of Croton tiglium and

China Journal of Chinese Materia Medica (2016)

Hai‐Guo Su Huai Yang Chun‐Wang Meng Cheng Peng Guo Li

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Chemical Composition and Antibacterial Activity of Essential Oils from Different Parts of Leonurus japonicus Houtt.

Molecules (2013)

Liang Xiong Cheng Peng Qin‐Mei Zhou Feng Wan Xiaofang Xie

The herb and fruits of Leonurus japonicus Houtt., named “Yimucao” and “Chongweizi”, respectively, in Chinese, have been widely used in China as gynecological medicines. The components of the essential oils obtained by hydrodistillation were investigated by GC-MS. The antibacterial activity of the essential oils was determined by micro-dilution assay. The results showed large variations in the chemical composition and antibacterial activity of the oils. The oil of “Yimucao” showed antibacterial activity against various Gram-positive bacteria and consisted mainly of sesquiterpenes and diterpenes, with phytone, phytol, caryophyllene oxide and β-caryophyllene being the most significant constituents, whereas the oil of “Chongweizi”, mainly made up of bornyl acetate and aliphatic hydrocarbons, was inactive in the antibacterial assay. Further study of the main compounds in “Yimucao oil” showed that β-caryophyllene had wide-spectrum activity against Gram-positive bacteria.

Caryophyllene

Phytol

10.3390/molecules18010963

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Citations (77)

Study on chemical constituents of seeds of Croton tiglium and their cytotoxicities

China Journal of Chinese Materia Medica (2016)

Hai‐Guo Su Huai Yang Chun‐Wang Meng Cheng Peng Li Guo

Seven compounds were isolated from the seeds of Croton tiglium by preparative TLC, semi-preparative HPLC, and column chromatography over silica gel, MCI, and Sephadex LH-20, etc. Their structures were elucidated by spectroscopic data analysis as bis(2,3-dihydroxypropyl) nonanedioate (1), 12-O-(α-methyl)butyrylphorbol-13-decanoate (2), 12-O-tiglylphorbol-13-decanoate (3), (9S,10R,11E,13R)-9,10,13-trihydroxyoctadec-11-enoic acid (4), methyl (9S,10R,11E,13R)-9,10,13-trihydroxyoctadec-11-enoate (5), 4(1H)-quinolinone (6), and 5-hydroxy-2-pyridinemethanol (7). Compound 1 was a new compound and compounds 4-7 were isolated from family Euphorbiaceae for the first time. Compounds 2 and 3 showed cytotoxic activities against human lung cancer cell line A549 with IC₅₀ values of 47.8 and 7.0 μmol•L ⁻¹, respectively, and against human hepatocarcinoma cell line HepG2 with IC₅₀ values of 71.4 and 44.0 μmol•L ⁻¹, respectively.

Euphorbiaceae

Sephadex

Croton

10.4268/cjcmm20161920

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Citations (4)

Sesquiterpenoids from the Herb of Leonurus japonicus

Molecules (2013)

Liang Xiong Qin‐Mei Zhou Cheng Peng Xiaofang Xie Li Guo

Two new sesquiterpenoids, (−)-(1S*,2S*,3R*)-3-ethoxycupar-5-ene-1,2-diol (1) and (−)-(1S*,4S*,9S*)-1,9-epoxybisabola-2,10-diene-4-ol (2), along with six known compounds 3−8, were isolated from the EtOH extract of the herb of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. In the in vitro assays, compounds 7 and 8 showed obvious antibacterial activity against several bacteria strains, while compound 3 significantly inhibited abnormal increase of platelet aggregation induced by ADP.

10.3390/molecules18055051

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Citations (41)