Mária Budai-Szűcs

University of Szeged

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Erzsébet Csányi

University of Szeged

Szilvia Berkó

University of Szeged

Anita Kovács

University of Szeged

Gábor Katona

University of Szeged

Ildikó Csóka

University of Szeged

Piroska Szabó‐Révész

University of Szeged

György Tibor Balogh

Semmelweis University

Attila Gácsi

University of Szeged

Rita Ambrus

University of Szeged

Katalin Burián

University of Szeged

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University of Szeged

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University of Novi Sad

Hungarian Academy of Sciences

Budapest University of Technology and Economics

Semmelweis University

Eötvös Loránd University

Institute of Materials and Environmental Chemistry

University of Pavia

HUN-REN Szegedi Biológiai Kutatóközpont

University of Pecs

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In situ gelling mucoadhesive eye drops: evaluation of physicochemical properties, in vitro dissolution and transcorneal permeability

Macedonian Pharmaceutical Bulletin (2023)

Boglárka Szalai Orsolya Jójárt-Laczkovich Mária Budai-Szűcs

10.33320/maced.pharm.bull.2023.69.03.023

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Citations (0)

Development of Thermoresponsive-Gel-Matrix-Embedded Amoxicillin Trihydrate-Loaded Bovine Serum Albumin Nanoparticles for Local Intranasal Therapy

Gels (2022)

Sandra Aulia Mardikasari Mária Budai-Szűcs László Orosz Katalin Burián Ildikó Csóka

A high dose of amoxicillin is recommended as the first-line therapy for acute bacterial rhinosinusitis (ABR). However, oral administration of amoxicillin is connected to many adverse reactions coupled with moderate bioavailability (~60%). Therefore, this study aimed to develop a topical nasal preparation of amoxicillin, employing a thermoresponsive nanogel system to increase nasal residence time and prolong drug release. Rheological investigations revealed that formulations containing 21–23% w/w Poloxamer 407 (P407) were in accordance with the requirement of nasal administration (gelling temperature ~35 °C). The average hydrodynamic diameter (<200 nm), pH (6.7–6.9), and hypertonic osmolality (611–663 mOsmol/L) of the in situ gelling nasal nanogel appeared as suitable characteristics for local rhinosinusitis treatment. Moreover, taking into account the mucoadhesive strength and drug release studies, the 21% w/w P407 could be considered as an optimized concentration for effective nasal delivery. Antibacterial activity studies showed that the ability of amoxicillin-loaded in situ gelling nasal nanogel to inhibit bacterial growth (five common ABR pathogens) preserved its effectiveness in comparison to 1 mg/mL amoxicillin aqueous solution as a positive control. Altogether, the developed amoxicillin-loaded in situ gelling thermoresponsive nasal nanogel can be a potential candidate for local antibiotic therapy in the nasal cavity.

Bovine serum albumin

Matrix (chemical analysis)

10.3390/gels8110750

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Citations (9)

Developments in Alloplastic Bone Grafts and Barrier Membrane Biomaterials for Periodontal Guided Tissue and Bone Regeneration Therapy

International Journal of Molecular Sciences (2024)

Rabia Ashfaq Anita Kovács Szilvia Berkó Mária Budai-Szűcs

Periodontitis is a serious form of oral gum inflammation with recession of gingival soft tissue, destruction of the periodontal ligament, and absorption of alveolar bone. Management of periodontal tissue and bone destruction, along with the restoration of functionality and structural integrity, is not possible with conventional clinical therapy alone. Guided bone and tissue regeneration therapy employs an occlusive biodegradable barrier membrane and graft biomaterials to guide the formation of alveolar bone and tissues for periodontal restoration and regeneration. Amongst several grafting approaches, alloplastic grafts/biomaterials, either derived from natural sources, synthesization, or a combination of both, offer a wide variety of resources tailored to multiple needs. Examining several pertinent scientific databases (Web of Science, Scopus, PubMed, MEDLINE, and Cochrane Library) provided the foundation to cover the literature on synthetic graft materials and membranes, devoted to achieving periodontal tissue and bone regeneration. This discussion proceeds by highlighting potential grafting and barrier biomaterials, their characteristics, efficiency, regenerative ability, therapy outcomes, and advancements in periodontal guided regeneration therapy. Marketed and standardized quality products made of grafts and membrane biomaterials have been documented in this work. Conclusively, this paper illustrates the challenges, risk factors, and combination of biomaterials and drug delivery systems with which to reconstruct the hierarchical periodontium.

Periodontium

Periodontal fiber

Bone grafting

10.3390/ijms25147746

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The effect of non-invasive dermal electroporation on skin barrier function and skin permeation in combination with different dermal formulations

Journal of Drug Delivery Science and Technology (2022)

Nikolett Kis Anita Kovács Mária Budai-Szűcs Gábor Erős Erzsébet Csányi

The aim of this research was to investigate the effect of non-invasive dermal electroporation (EP) on the barrier function of the skin and on the permeation of a model macromolecule in combination with different dermal formulations. Skin samples were treated with non-invasive dermal EP treatment for 2 min. Firstly, the effect of EP on the barrier function of the skin was examined on mouse skin in vivo by measuring transepidermal water loss (TEWL). Then, the effect of EP on human skin permeation was investigated ex vivo under a fluorescence microscope in combination with different dermal formulations. The human skin was treated with a solution, a hydrogel, and a film-forming system (FFS) containing 4 kDa fluorescein isothiocyanate-dextran (FITC-dextran) with or without EP. The increased fluorescence intensity shows the presence of FITC-dextran in the skin layers. The results showed, that the TEWL values increased rapidly after the treatment, and it took approximately 5 min to be restored. The results of permeation experiments showed that just slight permeation of FITC-dextran could be noticed from any formulation without EP; however, the permeation from the solution and the FFS increased highly in combination with EP. The EP decreased the barrier function of the skin reversibly and the structure of SC was restored in a short time after the treatment. FITC-dextran, as a macromolecule, can just slightly permeate into the skin with passive diffusion. EP could increase the permeation rate of FITC-dextran remarkably compared to the control treatments; however, the composition of the formulations has a great influence on the permeation.

Transepidermal water loss

Barrier function

Fluorescein isothiocyanate

Human skin

10.1016/j.jddst.2022.103161

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Development of ibuprofen-loaded nanostructured lipid carrier-based gels: characterization and investigation of in vitro and in vivo penetration through the skin

International Journal of Nanomedicine (2016)

Erzsébet Csányi Blanka Sütő Szilvia Berkó Gábor Kozma Ákos Kukovecz

Abstract: An ibuprofen-loaded nanostructured lipid carrier (IBU-NLC) was developed for enhanced skin penetration to improve the treatment of osteoarthritis and other musculoskeletal diseases. The mean particle size was 106 nm, with a spherical morphology, a smooth surface, and a zeta potential of −18.4 mV. X-ray diffraction studies revealed the amorphous state of the lipid matrix. Both Raman spectroscopy and Fourier transformation infrared analysis indicated no major shifts in the spectra of the formulations, which suggest rapid drug dissolution from the nanoparticles. The drug loading was 9.85%, and the entrapment efficiency was 98.51%. In vitro release of the NLC dispersion, in vitro permeation, and in vivo animal studies of IBU-NLC gel all confirmed that the permeation of IBU was significantly better than that of a reference after 6 hours. In conclusion, IBU-NLC gel is of great potential to enhance drug permeation through the skin and hence the efficacy of the treatment of chronic joint inflammation. Keywords: ibuprofen, nanostructured lipid carriers, skin penetration, SKH-1 hairless mice, osteoarthritis

Zeta potential

Penetration (warfare)

Ibuprofen

10.2147/ijn.s99198

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Citations (63)

Design and Optimization of Nanostructured Lipid Carrier Containing Dexamethasone for Ophthalmic Use

Pharmaceutics (2019)

Eszter L. Kiss Szilvia Berkó Attila Gácsi Anita Kovács Gábor Katona

The aim of this study was to perform a preformulation study of dexamethasone (DXM)-loaded nanostructured lipid carriers (NLCs) for ocular use. Lipid screening was applied to find the most suitable solid and liquid lipids and surfactant for the NLC formulation. The visual observation was proved with XRD measurements for the establishment of the soluble state of DXM. Thermoanalytical measurements indicated that the most relevant depression of the crystallinity index could be ensured when using a 7:3 solid lipid:oil ratio. In order to optimize the NLC composition, a 23 full factorial experimental design was used. It was established that each independent factor (lipid, DXM, and surfactant concentration) had a significant effect on the particle size while in the case of entrapment efficiency, the DXM and surfactant concentrations were significant. Lower surfactant and lipid concentrations could be beneficial because the stability and the entrapment efficacy of NLCs were more favorable. The toxicity tests on human cornea cells indicated good ophthalmic tolerability of NLCs. The in vitro drug release study predicted a higher concentration of the solute DXM on the eye surface while the Raman mapping penetration study on the porcine cornea showed a high concentration of nanocarriers in the hydrophylic stroma layer.

Nanocarriers

Solid lipid nanoparticle

10.3390/pharmaceutics11120679

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Citations (40)

Soluplus® promotes efficient transport of meloxicam to the central nervous system via nasal administration

International Journal of Pharmaceutics (2023)

Bence Sipos Zsolt Bella Ilona Gróf Szilvia Veszelka Mária A. Deli

Mucoadhesion

Meloxicam

Nanocarriers

Ex vivo

10.1016/j.ijpharm.2023.122594

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Citations (12)

Papaverine hydrochloride containing nanostructured lyotropic liquid crystal formulation as a potential drug delivery system for the treatment of erectile dysfunction

Drug Design Development and Therapy (2018)

Szilvia Berkó Stella Zsikó Gábor Deák Attila Gácsi Anita Kovács

Purpose: Papaverine hydrochloride (PaHCl) is an old, well-known drug with spasmolytic activity but it has therapeutic effect in erectile dysfunction, too. As an intracavernous injection, it is not used in urologic clinics today because the side effects of the injection are pain, scarring or priapism. Our aim was to develop and test a topical semi-solid preparation containing PaHCl that would provide an alternative administration option by eliminating the undesirable side effects of the injection. Materials and methods: Lyotropic liquid crystal (LLC) systems were formulated as a semi-solid preparation with different concentrations of PaHCl. The characterization of the LLC structure was performed by polarization microscopy using a Leica image analyzer and rheological measurements. The drug diffusion and penetration tests were performed with in vitro synthetic membrane and an ex vivo human epidermis, using Franz diffusion cell to test the skin penetration of PaHCl. Human skin was investigated by Raman microscope to visualize the Active Pharmaceutical Ingredient (API) in different skin layers. Results: The results of diffusion and penetration showed reverse concentration dependency. The in vitro and ex vivo studies correlated with each other and the results of Raman microscopy. The LLC structure influenced the penetration results, the lower viscosity and lamellar structure increased penetration through the skin. Conclusion: Based on our results, a PaHCl containing topically used LLC formulation may be a suitable and effective alternative to the injectable formulation. Keywords: nanocarrier, dermal penetration, impotence, Raman microscopy

Lyotropic

Lyotropic liquid crystal

Hydrochloride

10.2147/dddt.s168218

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Citations (25)

New Approach of Sucrose Myristate as a Promising Penetration Enhancer in Dermal Preparations

Tenside Surfactants Detergents (2015)

Boglárka Balázs Eszter Csizmazia Szilvia Berkó Mária Budai-Szűcs Piroska Szabó‐Révész

Abstract The aim of this work was to compare the penetration enhancer effect of newly developed sucrose myristate with the generally used sucrose laurate. Hydrogel formulations containing sucrose esters (SEs) were prepared and the model drug was Ibuprofen (IBU), which has oral side effects, so applying it in a transdermal system could be useful. We evaluated the effect of SE hydrogel formulations on the skin by the noninvasive in vivo test and examined their concentration dependent influence on the penetration of IBU through a synthetic membrane ( in vitro ) by the Franz cell method. The results indicated that sucrose myristate incorporated into hydrogel moistures the skin well and lastingly and showed a better drug penetration enhancing effect at a much lower concentration compared to sucrose laurate. Our results revealed that sucrose myristate could be a promising and effective penetration enhancer in the pharmaceutical field.

Penetration (warfare)

Ibuprofen

10.3139/113.110388

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Citations (3)

Study of sodium hyaluronate-based intranasal formulations containing micro- or nanosized meloxicam particles

International Journal of Pharmaceutics (2015)

Csilla Bartos Rita Ambrus Péter Sipos Mária Budai-Szűcs Erzsébet Csányi

Meloxicam

Polyvinyl Alcohol

Mucoadhesion

10.1016/j.ijpharm.2015.06.046

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Citations (46)