M. Lanuza

Hospital Universitario Virgen de la Arrixaca

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Raquél Rodado

Hospital Universitario Virgen de la Arrixaca

Luisa Jimeno

Hospital Universitario Virgen de la Arrixaca

Rafael García-Ramón

Universitat de València

A. Martínez

Hospital Universitario Virgen de la Arrixaca

Javier Castro Alvariño

Universidade da Coruña

Jocelyn Olivares

The University of Texas Southwestern Medical Center

Diana Manzano

Hospital Universitario Virgen de la Arrixaca

J Montolíu

Hospital Universitari Arnau de Vilanova

Carmen Gómez‐Roldán

Hospital General Universitario de Albacete

Javier Pérez-Contreras

Hospital General Universitario de Alicante Doctor Balmis

Cooperative Institutions

Hospital Universitario Virgen de la Arrixaca

Universitat de Barcelona

Hospital Txagorritxu

Pediatric Nephrology of Alabama

Instituto de Salud Carlos III

Universitat de València

Hospital Clínico Universitario de Valencia

Hospital Universitario La Paz

Universidad Autónoma de Madrid

Hospital Clínic de Barcelona

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Prevalence and risk factors for hepatitis C virus infection in continuous ambulatory peritoneal dialysis patients

Nephrology Dialysis Transplantation (1996)

José Luis Górriz Álvaro Flores de Miguel Rafael García-Ramón Javier Pérez-Contreras Jocelyn Olivares

Studies on hepatitis C virus antibodies (Anti-HCV) in CAPD patients are scarce and include a small number of patients. Nevertheless, risk factors related to Anti-HCV in these patients are still subject to controversy. To analyse the incidence and risk factors associated with the presence of Anti-HCV in CAPD patients. We studied 255 patients from five different treatment centres of our region. The analysis was repeated after excluding 161 patients who had previously received haemodialysis treatment at least once. Anti-HCV testing was made by the 2nd-generation ELISA. As a supplementary test we used RIBA-4 in three centers and INNOLIA in the other two. Risk factors were analysed using logistic regression model for multivariate analysis. In the whole group, 29 patients (11.4%) were anti-HCV positive. Logistic regression analysis determined the following variables as independent risk factors: hepatitis previous to CAPD (P<0.0001, odds ratio (OR): 44.9), Anti HBc positivity (P=;0.019, OR: 9.24), blood transfusions previous to CAPD (P=;0.015, OR: 1.05) and CAPD duration (P=0.025, OR: 1.02). When patients who had previously undergone haemodialysis were excluded, the prevalence of HCV antibodies was 8.5% (8/94). In this group multivariate analysis showed that Anti-HCV positivity correlated with hepatitis previous to CAPD (P<0.0003, OR: 126) and Anti HBc positivity (P=0.002, OR: 41.9). Our prevalence of hepatitis C virus (HCV) infection in CAPD patients was lower than other renal replacement therapy modalities, and correlated to events occurring mainly before starting CAPD treatment. This technique could be considered as low risk for HCV infection.

Hepatitis C

10.1093/ndt/11.6.1109

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Our Nine-Year Experience with the Self-Locating Catheter: Comparison of Malfunction Rate with Other Tenckhoff Catheter Variants

The International Journal of Artificial Organs (2006)

M. Lanuza José Ignacio Minguela Raquél Rodado Joaquin M. Muriel Ramón Ruiz-de-Gauna

Objective To evaluate catheter-related complications among self-locating and other variants of Tenckhoff catheters. Patients and Methods We studied all self-locating catheters implanted in our hospitals from May/97 to Dec/05. We extended the follow-up to Jun/05. We collected demographic data, causes of catheter withdrawal and dropping of PD. We studied data about technique and catheter related complications. Results We included 328 catheters in 285 patients. There were 258 self-locating, 55 straight and 15 curled. There was a higher rate of catheter withdrawal due to malfunction in patients with straight or pig-tail catheters than in self-locating ones (log-rank, p<0.001). Conclusion In our patients, self-locating catheters have a lower malfunction rate than other variants of Tenckhoff catheters.

10.1177/039139880602900114

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Lower Malfunction Rate with Self-Locating Catheters

Peritoneal Dialysis International (2001)

Ignacio Minguela M. Lanuza Ramón Ruiz de Gauna Raquél Rodado Soledad Alegría

Objective We analyzed malfunction rates (obstruction, omental wrapping, displacement) and catheter survival for self-locating catheters as compared with other Tenckhoff catheter designs. Patients and Methods We conducted our survey at two centers, prospectively studying all self-locating catheters implanted from May 1997 to October 2000 and used for peritoneal dialysis (PD). Tenckhoff catheters of other designs used previously in our units were used as the control group. We analyzed removal causes and catheter survival. Results We studied 173 catheters (105 self-locating catheters, 53 straight catheters, and 15 coiled catheters) implanted in 139 patients (43% of them women) with a mean age of 53 ± 14 years. The analysis of catheter removal showed that 3 of 105 self-locating catheters, 3 of 15 coiled catheters, and 17 of 53 straight catheters were removed owing to malfunction (c 2 : p = 0.0000). Kaplan–Meier curves showed that the bulk of removals for malfunction occurred within the first 3 months after PD start. The group of self-locating catheters showed better survival (log-rank: p = 0.0009). Other causes for catheter removal included peritonitis ( n = 22), exit-site infection alone ( n = 4), and end of PD treatment ( n = 66). No significant differences were seen in the annual peritonitis rate (straight-tip: 0.955 ± 2.315 episodes annually; coiled-tip: 0.651 ± 0.864 episodes annually; self-locating: 0.720 ± 1.417 episodes annually; t-test: p > 0.400). No gut or bladder perforations were observed. Conclusion In our survey, self-locating catheters were associated with better survival and fewer removals for malfunction than were Tenckhoff catheters of other designs.

Exit site

Log-rank test

10.1177/089686080102103s36

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INFLUENCE OF EPIDEMIOLOGIC FACTORS IN THE DEVELOPMENT OF POSTTRANSPLANT ERYTHROCYTOSIS. ROLE OF ANDROGENS.

Transplantation (2004)

Luisa Jimeno Raquél Rodado Mario Gonzalez Mário Hebling Campos M. Lanuza

P296 Aims: Posttransplant Erythrocytosis (PTE) is a relatively common phenomenon associated with an increased risk of thromboembolism. Many factors have been linked to an increased incidence of PTE, including age of donor, treatment with rHuEpo prior to transplantation, rejection, diabetes and transplant artery stenosis. PTE is more frequent in males. Its etiology and causative factors are still a matter of controversy. Androgens promote erythrocytosis via stimulation of erythroid progenitors and have been succesfully used to ameliorate anemia in dialysis. Dehydroepiandrosterona (DHEA) is an androgen which is synthesized in the suprarenal gland. Its pathogenic role in the development of posttransplant erythrocytosis has not been sufficiently studied. This prospective study was undertaken to define which factors are associated with the development of PTE and to determine if androgens play a pathogenic role in it. Methods: The study included 41 kidney graft recipients. They were divided into two groups: group 1 consisted of 21 patients (18 males, 3 females) with Ht > 51% and group 2 was made up of 20 patients (13 males, 7 females) with normal Ht. Serum creatinine levels were less than 2 mg/dl in all patients. Age and sex of donor and receptor, time in dialysis (months), Ht levels prior to transplantation, time of cool ischemia, acute rejection, acute tubular necrosis, rHuEpo pre-transplantation, immunosuppressive treatment and the presence or absence of hypertension were evaluated. Ht values were related to each parameter. Exclusion criteria were: poliquistic disease and artery renal stenosis. As well as the following in a period of two months prior to the study: ACEIs, diuretics or iron treatment, transfusions or surgical procedure. Serum DHEA levels were determined in both groups of patients and compared between them. Men and women were separately analysed in each group in order to determine if the greater number of males in group 1 could influence the results. The statistical analysis was performed by using Student’s test for two independent samples (data were previously transformed by ln).and χ2 Pearson for qualitative variables. Results: There were no differences in both groups. Only hypertension was more frequent in patients with PTE (p<0.01). DHEA levels in group 1 were significantly higher than in group 2 (78.5 ±42.8 to 45.1 ± 37.1 respectively) (p<0.02). In addition when only men were compared, significant diferences were found (81.3 ± 35.7 in group 1 to 50.3 ± 36.2 in group 2) (p<0.01). However, there were no significant differences when only women were compared. Conclusions: 1.- The prevalence of hypertension is higher in patients with PTE than in controls. No other factors were different. 2.- DHEA seems to play an important role in the pathogenesis of PTE in men. 2.-There were no differences between women with PTE and with normal Ht. The reason for this result is most likely because of the low number of women included in this study. However, the posibility that androgens do not play any role in the pathogenesis of PTE in women cannot be excluded.

Etiology

10.1097/00007890-200407271-00791

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[Pregnancy specific beta 1 glycoprotein in patients with solid tumors].

PubMed (1982)

M. Lanuza J Montolíu Lola Andreu J López-Pedret L Revert

BETA (programming language)

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Absence of seroconversion to hepatitis C virus infection in CAPD patients

Nephrology Dialysis Transplantation (1997)

J. M. Górriz A. San Miguel R. Garcia-Ramon C. Gomez-Roldan Jocelyn Olivares

Seroconversion

Hepatitis C

10.1093/ndt/12.2.373

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Citations (3)

A comparative survey on the incidence of kidney graft primary vascular thrombosis among CAPD and haemodialysis patients

Nephrology Dialysis Transplantation (1996)

Fernando Escuín Gloria del Peso Miguel Pérez Fontán Adrien Carmona A. Martinez

10.1093/oxfordjournals.ndt.a027704

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Citations (9)

Acute Abdomen in Chronic Renal Failure

The Nephron journals/Nephron journals (1982)

Alberto Martínez-Vea J Montolíu C. Monroy M. Lanuza Lopez Pedret

Chronic renal failure

Nephrology

10.1159/000182867

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Enhanced Influenza Surveillance Utilizing Rapid Diagnostic Tests in the Emergency Department

Journal of Global Antimicrobial Resistance (2024)

Janice Caoili Aliza S. Concepcion M. Lanuza Heloisa Nicole Dayap Maria Reinaluz Bactol

10.1016/j.jgar.2024.10.233

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P1157IMPACT OF MODE OF DIALYSIS ON COMPLICATIONS AFTER SIMULTANEOUS PANCREAS- KIDNEY TRANSPLANTATION

Nephrology Dialysis Transplantation (2020)

A. Martínez M. Lanuza Diana Manzano F. Villalba López Eulalia Carceles

Abstract Background and Aims Simultaneous pancreas-Kidney transplantation (SPKT) has established its position in treating patients with type 1diabetes and end-stage renal disease. Infections in the early post-transplantation period are one of the most significant causes of the high morbidity and mortality rates associated with SPKT. Pre-transplant dialysis modality may affect evolution and it has suspected that peritoneal dialysis (PD) is associated whit more surgical complications, especially intra-abdominal infections. The aim: evaluate whether pretransplant dialysis modality affects the risk for postoperative complications in SPKT transplant recipients Method retrospective and descriptive study of a series of patients who underwent SPKT from 2000 to 2018 in our hospital. We studied complication occurring during the first 3 months after transplantation Results From 2000 to 2019 we performed 38 SPKT in 22 men and 16 women. The mean age of the patients was 35.3(28-44) years. Of the 38 SPKT patients, 44.7% on hemodialysis before transplantation, 26.3% were on peritoneal dialysis and 28.9% had not received any substitutive renal therapy. Were similar regarding baseline characteristics. The complications of the post-transplant period are shown in graph 1. The most frequent complications were infectious in almost 2/3 of the patients and within them the intra-abdominal infections affected almost half, 18, of the patients. Were 3 thrombosis of the pancreas that caused the loss of the graft but none of the kidney. All early postoperative complications are compared in table 1.Whit no significant difference between groups of intraabdominal infection (p. 0.5) and graft thrombosis (p 0.7). There were also no differences in relaparotomy, acute rejection and delayed graft function During the follow-up 4 patients died, one case due to a heart attack while the other 3 in relation to intraabdominal infectious processes and need for reintervention Conclusion: Despite improvements in the outcomes of STKP infectious complications remain a significant cause of morbidity and mortality Peritoneal dialysis is not a risk factor postoperative complication after STPK

10.1093/ndt/gfaa142.p1157

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