K. Venuprasad

Southwestern Medical Center

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Arianne L. Theiss

University of Colorado Denver

Dakota N. Jackson

Baylor University Medical Center

Kibrom M. Alula

University of Colorado Anschutz Medical Campus

Rhonda F. Souza

Baylor Medical Center at Garland

Yaritza Delgado‐Deida

University of Colorado Denver

Redouane Tabti

Regenerative NanoMedicine

Laurent Désaubry

Regenerative NanoMedicine

Xuan Wang

Union Hospital

Kevin T. Turner

University of Pennsylvania

Mahesh Kathania

Southwestern Medical Center

Cooperative Institutions

The University of Texas Southwestern Medical Center

Southwestern Medical Center

Baylor University

Baylor University Medical Center

Wayne State University

Mayo Clinic

Baylor Medical Center at Garland

The Barbara Ann Karmanos Cancer Institute

University of Toronto

WinnMed

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The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1

Nature Immunology (2008)

K. Venuprasad Haining Huang Yohsuke Harada Chris Elly Malayannan Subramaniam

Transcription

10.1038/ni1564

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Citations (167)

Supplementary Data from The Synthetic Small Molecule FL3 Combats Intestinal Tumorigenesis via Axin1-Mediated Inhibition of Wnt/β-Catenin Signaling

Dakota N. Jackson Kibrom M. Alula Yaritza Delgado‐Deida Redouane Tabti Kevin T. Turner

FL3 induces death of established colonic tumoroids derived from mice.

10.1158/0008-5472.22426635

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Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation

Journal of Visualized Experiments (2016)

K. Venuprasad Balamayooran Theivanthiran Brandi L. Cantarel

Here, we describe a detailed procedure to efficiently and directly deliver Haemophilus influenzae into the lower respiratory tracts of mice. We demonstrate the procedure for preparing H. influenzae inoculum, intra-tracheal instillation of H. influenzae into the lung, collection of broncho-alveolar lavage fluid (BALF), analysis of immune cells in the BALF, and RNA isolation for differential gene expression analysis. This procedure can be used to study the lung inflammatory response to any bacteria, virus or fungi. Direct tracheal instillation is mostly preferred over intranasal or aerosol inhalation procedures because it more efficiently delivers the bacterial inoculum into the lower respiratory tract with less ambiguity.

Respiratory tract

Aerosolization

10.3791/53964

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Citations (2)

The E3 ubiquitin ligase Itch regulates Foxp3 expression and airway inflammation via enhancing TIEG1 function

The FASEB Journal (2008)

K. Venuprasad Haining Huang Yohsuke Harada Chris Elly Malayannan Subramanyam

Transforming growth factor (TGF)‐b signaling in naïve T cells induces expression of transcription factor Foxp3, a master regulator in the regulatory T cells (Tregs). However, the molecular mechanisms leading to Foxp3 induction remain unclear. Here we show that Itch−/− T cells are resistant to TGF‐b treatment with reduced Foxp3 expression. The E3 ubiquitin ligase Itch associates with and promotes ubiquitin conjugation to TGF‐b inducible early gene1 product (TIEG1). More importantly, Itch cooperates with TIEG1 to induce Foxp3 expression, which is reversed by TIEG1 deficiency. Functionally TGF‐b‐converted Tregs generated from TIEG1−/− mice are unable to inhibit naïve T cell proliferation in vitro and suppress airway inflammation in vivo. The results suggest an ubiquitin‐dependent non‐proteolytic pathway that is critical for Foxp3 expression and regulation of allergic responses.

10.1096/fasebj.22.1_supplement.848.6

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Cellular signaling, molecular activation, and regulation of the NLRP6 inflammasome

Elsevier eBooks (2022)

Elviche L. Tsakem Sandip Mukherjee Arianne L. Theiss K. Venuprasad

Pyrin domain

AIM2

NALP3

NOD1

10.1016/b978-0-323-91802-2.00023-2

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Nuclear partitioning of Prohibitin 1 inhibits Wnt/β-catenin-dependent intestinal tumorigenesis

Oncogene (2020)

Kibrom M. Alula Yaritza Delgado‐Deida Dakota N. Jackson K. Venuprasad Arianne L. Theiss

Prohibitin

Adenomatous polyposis coli

10.1038/s41388-020-01538-y

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Citations (12)

Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation

Cell Reports (2022)

Mahesh Kathania Ritesh Kumar Elviche Taskem lenou Venkatesha Basrur Arianne L. Theiss

10.1016/j.celrep.2022.111345

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Citations (5)

Supplementary Data from The Synthetic Small Molecule FL3 Combats Intestinal Tumorigenesis via Axin1-Mediated Inhibition of Wnt/β-Catenin Signaling

Dakota N. Jackson Kibrom M. Alula Yaritza Delgado‐Deida Redouane Tabti Kevin T. Turner

FL3 induces death of established colonic tumoroids derived from mice.

10.1158/0008-5472.22426635.v1

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Citations (0)

CD28 signaling in neutrophil induces T-cell chemotactic factor(s) modulating T-cell response

Human Immunology (2002)

K. Venuprasad Subhasis Chattopadhyay Bhaskar Saha

10.1016/s0198-8859(02)00689-4

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Citations (21)

Cbl-b and Itch: Key Regulators of Peripheral T-cell Tolerance

Cancer Research (2010)

K. Venuprasad

Abstract E3 ligases Cbl-b and Itch have emerged as dominant “tolerogenic” regulators of T cells because their deficiency results in severe autoimmune diseases. Cbl-b and Itch ligase activity regulate T-cell anergy and development of Foxp3+ regulatory T cells (Treg) in the periphery by modulating key components of T-cell receptor (TCR) and transforming growth factor-β (TGF-β) signaling. Manipulation of Cbl-b and Itch activities may provide unique opportunities to develop future therapies for immune disorders such as autoimmunity and cancer. Cancer Res; 70(8); 3009–12. ©2010 AACR.

Peripheral tolerance

Regulatory T cell

10.1158/0008-5472.can-09-4076

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Citations (44)