Zijia Liu

University of Chinese Academy of Sciences

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Yuelun Zhang

Chinese Academy of Medical Sciences & Peking Union Medical College

Qian Li

Southwest University of Science and Technology

Zaiming Ge

Institute of Oceanology

Yiping Shuai

Hunan University

Zhengchao Wu

Shenyang Agricultural University

Chao Sheng

Beijing Jishuitan Hospital

Guangtao Zhai

Shanghai Jiao Tong University

Weiwen Zhou

Shanghai Academy of Spaceflight Technology

Zhixiang Zhou

University of South China

Duo Tang

Beijing University of Technology

Cooperative Institutions

Shanghai Jiao Tong University

Chinese Academy of Medical Sciences & Peking Union Medical College

University of Chinese Academy of Sciences

Chinese Academy of Sciences

Capital Medical University

Peking Union Medical College Hospital

Beijing University of Technology

Wuhan University

Sun Yat-sen University

Peking University

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High cellular plasticity state of medulloblastoma local recurrence and distant dissemination

Cell Reports Medicine (2025)

Hailong Liu Jing Zhang Ziwei Wang Wei Wang Dongming Han

Medulloblastoma (MB), a heterogeneous pediatric brain tumor, poses challenges in the treatment of tumor recurrence and dissemination. To characterize cellular diversity and genetic features, we comprehensively analyzed single-cell/nucleus RNA sequencing (sc/snRNA-seq), single-nucleus assay for transposase-accessible chromatin sequencing (snATAC-seq), and spatial transcriptomics profiles and identified distinct cellular populations in SHH (sonic hedgehog) and Group_3 subgroups, with varying proportions in local recurrence or dissemination. Local recurrence showed higher cycling tumor cell enrichment, whereas disseminated lesions had a relatively notable presence of differentiated subsets. Chromosomal alteration evaluation revealed distinct genetic subclones during MB progression, such as chr7q gain and chr11 loss in Group_3 disseminations. A subpopulation termed "high cellular plasticity (HCP)" emerged during MB progression and was associated with increased dividing potential and chromatin accessibility, contributing to recurrence. Inhibiting HCP-associated markers, like protein tyrosine phosphatase receptor type Z1 (PTPRZ1), efficiently suppressed MB progression in preclinical models. These findings address critical gaps in understanding the cellular diversity, chromosomal alterations, and biological dynamics of recurrent MB, offering potential therapeutic insights.

10.1016/j.xcrm.2024.101914

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Experimental Teaching of Product Model Making in the Technological Era

Yishu yu sheji (2008)

Zijia Liu

product model making is a form of solid expression,which is important process of product development. Today,though computer manufacturing technology become a new method of model making,traditional handing method still be powerful in the future because of its advantages. After comparing with handing model and computer manufacturing technology,this paper revealed the significance of experimental teaching of handing model for industrial design in the technological era.

Product model

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Biophysical controls on seasonal changes in the structure, growth, and grazing of the size-fractioned phytoplankton community in the northern South China Sea

Yuan Dong Qian Li Zhengchao Wu Yiping Shuai Zijia Liu

Abstract. The size-fractionated phytoplankton growth and microzooplankton grazing are crucial for the temporal change of community size-structure, regulating not only trophic transfer but also carbon cycle of the ocean. However, the size-dependent growth and grazing dynamics on monthly or an annual basis are less addressed in the coastal ocean. In this paper, the seasonal responses of the size-fractionated phytoplankton growth and grazing to environmental change were examined over a one-year period at a coastal site of the northern South China Sea. We found a nanophytoplankton dominated community with strong seasonal variations of all size classes. Phytoplankton community growth rate was positively correlated to nutrients with community grazing rate correlating to the total chlorophyll-a at the station, reflecting a combined bottom-up and top-down effect on phytoplankton population dynamics. Further analyses suggested that the specific growth rate of microphytoplankton was significantly influenced by phosphate with that of nanophytoplankton by light, although picophytoplankton growth was controlled by both nitrate and temperature. In addition, the specific grazing rate of nanophytoplankton was well correlated to phytoplankton standing stock, while those of micro- and pico-compartments were negatively influenced by ciliate abundance and salinity. Finally, a lower grazing impact for micro-cells (38 %) than nano- and pico-cells (72 % and 60 %, respectively) may support a size-selective grazing of microzooplankton on small cells at this eutrophic system.

10.5194/bg-2021-226

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Variability of plankton size distribution and controlling factors across a coastal frontal zone

Progress In Oceanography (2021)

Zijia Liu Qian Li Zaiming Ge Yiping Shuai

Picoplankton

10.1016/j.pocean.2021.102665

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Citations (8)

Application of improved fuzzy mathematical comprehensive evaluation method to evaluation of groundwater quality in Changchun City

Zijia Liu

An improved fuzzy mathematical comprehensive evaluation method was used to evaluate the groundwater quality in the southeastern ecological region and the southwestern industrial region of Changchun City,in Jilin Province. The results show that the groundwater quality in the southwestern industrial region of Changchun City reached the grade IV level,and the main factors influencing the water quality were heavy metal ions. Therefore,effective measures should be taken to prevent groundwater pollution in this region. In addition,the groundwater quality in the southeastern ecological region of Changchun City reached the grade Ⅱ level,superior to that of the southwestern industrial region.

Industrial city

Groundwater Pollution

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The Reflection on the Flaws of Modern Design Products,Taking a Certain Brand Soybean Milk Machines As the Examples

Yishu yu sheji (2011)

Zijia Liu

There is often a defective product unsatisfactory in people's daily appliances,so that they have to be selective and more careful consideration when choose to buy product.In order to understand the defects of the products and propose a good solution,we must start from the basic requirements of product design by combining with practical cases,this article cites certain brand soybean milk machines as an example to analyze the existing flaws of the products and proposes some solutions for the product defects.

CITES

Reflection

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Realization of Material with an Atomic Ruby Lattice

Nano Letters (2024)

Zijia Liu Shengdan Tao Huiru Liu Chen Ma Panyin Li

The ruby lattice is one of the tight-binding models which hosts a flat band in its electronic structure and has potential applications in future spintronics and quantum devices. However, the experimental realization of a ruby lattice in realistic materials remains elusive. Here, we have experimentally realized an atomic ruby lattice by fabricating monolayer CuCl1+x on a Au(111) substrate. Scanning tunneling microscopy/spectra (STM/STS) measurements combined with density-functional theory (DFT) calculations reveal that the Cu atoms are arranged in a ruby lattice in this monolayer. Moreover, a significant density of states (DOS) peak corresponding to the characteristic of a ruby system is observed, consistent with both the tight-binding model and first-principles calculations on the band structure. Our work provides a promising platform to explore the physics of the ruby model.

Lattice (music)

10.1021/acs.nanolett.4c03236

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Temporal change of plankton size structure preserved by Lugol’s solution: a FlowCAM study

Journal of Oceanology and Limnology (2022)

Zijia Liu Yuan Dong Qian Li Zhengchao Wu Zaiming Ge

Mesocosm

10.1007/s00343-021-1155-1

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Research of the Texture of Material in Modern Furniture Design

Yishu yu sheji (2009)

Zijia Liu

Based on the texture of materials,the article analysises the texture and color matching of materials with their feeling feature,and explores the color and texture matching in furniture used in different environments,then meets the psychological needs of different people to make design works showing a rich aesthetic appearance.

Texture (cosmology)

Feature (linguistics)

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The Art Communication in the Silk Road Culture,Take Beijing Olympics Games' Opening Ceremony for Example

Yishu yu sheji (2011)

Zijia Liu

In ancient times,the Silk Road is the road to spread friendships and the important cultural symbol to promote the cultures' communication.But in today's society,the Silk Road is the link to connect the East and the West' civilizations,it not only conveys the culture,but uses different artistic forms of the art communication symbols,and it uses of the combination of modern technology and long history culture to continuously spread to the world about China's splendid culture,it shows great Chinese nation and their strong spirit of endless struggle to the world.

Symbol (formal)

Opening ceremony

Ceremony

Cultural Communication

Ancient culture

Chinese culture

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