Aging rhesus monkeys, both controls and those undergoing long-term administration of investigational oral contraceptive steroids, developed widespread hyperfluorescent dots at the posterior pole. The dots were considered to represent drusen. Histologic (including electron microscopic) study showed the "drusen" in some of the animals to be almost exclusively pigment epithelial windows produced by a lipoidal degeneration of the pigment epithelial cells. The experiment provided a fortuitous model for direct correlation of clinical and histologic observations of myriad uniform, tiny, depigmented, hyperfluorescent, nonleaking spots at the level of the retinal pigment epithelium.
An eight-month-old, male domestic shorthair kitten developed progressive abdominal distension over a six-week period. Abdominocentesis revealed a fluid with high protein (3.8 g/dl) and moderate cellularity. Infectious, cardiovascular, and neoplastic causes of posthepatic obstruction were ruled out. Partial obstruction and stenosis of the caudal vena cava (CVC) at the level of the diaphragm were detected on a contrast venogram. Exploratory surgery revealed a fibrous, web-like membrane at the site of obstruction. Resection of the stenotic segment of the CVC was not possible because of the junction of the left hepatic veins and CVC just caudal to the lesion. A 3 by 6-mm, oval Dacron patch graft was sutured into the venotomy site. Postoperative complications included fever and leukocytosis, eosinophilic pleural effusion, and transient congestive heart failure associated with volume overload. The cat is normal 16 months after surgery, with no recurrence of ascites. This is the first reported case of Budd-Chiari syndrome (BCS) in a domestic kitten. Documented herein is the first successful treatment of BCS in a small animal using a vascular, prosthetic patch graft.
SUMMARY Twenty-two Hereford heifers were injected im with prostaglandin F 2α a , 11 days apart to synchronize estrous cycles. Twelve of 14 heifers that had signs of estrus were inoculated iv with 1 of 3 modified-live infectious bovine rhinotracheitis virus vaccines, and 2 were assigned to a nonvaccinated control group. Also, 6 of the 8 anestrous heifers were inoculated iv with 1 of the 3 vaccines on the fourth day after the last prostaglandin injection and the other 2 were assigned to the nonvaccinated group. Vaccine virus was isolated from the blood and nasal and vaginal secretions from the vaccinated heifers on postvaccination days 4, 7, and 9. On postvaccination day 9, all heifers were ovariectomized and ovarian tissues were processed for virus isolation and histologic examination. Vaccine virus was isolated from ovarian tissues of some heifers in each of the vaccine groups. Necrotic oophoritis characterized by multifocal areas of ovarian tissue necrosis, hemorrhage, and mononuclear lymphocytic infiltration was observed. The corpora lutea and surrounding ovarian tissues taken from vaccinated heifers in each group had varying amounts of necrotic and inflammatory change, but the changes appeared to be more severe in 1 group than in the other 2. Virus also was isolated from 2 of the controls; these heifers apparently became infected with vaccine virus that had been excreted from the vaccinated animals.
Journal Article Biologic Properties of Cell Lines Derived From Canine Mammary Carcinomas Get access Lauren G. Wolfe, Lauren G. Wolfe Search for other works by this author on: Oxford Academic PubMed Google Scholar Bonnie Buxton Smith, Bonnie Buxton Smith Search for other works by this author on: Oxford Academic PubMed Google Scholar Maria A. Toivio-Kinnucan, Maria A. Toivio-Kinnucan Search for other works by this author on: Oxford Academic PubMed Google Scholar Eva A. Sartin, Eva A. Sartin Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert P. Kwapien, Robert P. Kwapien Search for other works by this author on: Oxford Academic PubMed Google Scholar Ralph A. Henderson, Ralph A. Henderson Search for other works by this author on: Oxford Academic PubMed Google Scholar Stephen Barnes Stephen Barnes Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 77, Issue 3, September 1986, Pages 783–792, https://doi.org/10.1093/jnci/77.3.783 Published: 01 September 1986 Article history Received: 20 November 1985 Accepted: 12 May 1986 Published: 01 September 1986
A microsporidian infection was diagnosed in a pied peach-faced lovebird (Agapornis roseicollis) which had died after an illness of 2 days. The parasite was observed in the liver, kidney, and small intestine. Lesions were most severe in the liver, with numerous organisms adjacent to areas of hepatic necrosis. Although the organisms were seen within renal tubules and within the intestinal mucosa, inflammatory lesions in those sites were minimal. The microsporidian nature of the parasite was confirmed by morphologic studies. The genus of the organism was not determined.
Summary Estrogen and progesterone receptors ( er , pr ) were measured in cytosol fractions from 18 primary canine mammary carcinomas by use of biochemical assays. One or both receptors were detected (> 10 fmol/mg of cytosol protein) in 11 tumors: 5 er and pr ; 2 er only; 4 pr only. Mean cytoplasmic receptor concentrations (fmol/mg of cytosol protein) were 22.8 ± 2.9 ( sem ) for er and 51.0 ± 10.3 for pr in tumors containing er and pr , 28.8 ± 12.1 for er in tumors containing only er and 13.2 ± 1.5 for pr in tumors containing only pr . Estrogen or progesterone receptors or both were identified in 6 of 9 tubular adenocarcinomas, 4 of 5 papillary adenocarcinomas, and 1 of 1 squamous cell carcinoma. These receptors were not identified in solid carcinomas (n = 2) or a single spindle cell carcinoma. Although the number of cases was limited, survival times of dogs tended to be longest in those with tumors containing er alone or in combination with pr , intermediate in those with tumors containing only pr , and shortest in those with tumors without er or pr . A correlation was not apparent between receptor status and age, presence of ovaries, tumor size, or histologic classification of the tumor. In the analysis of this series, the extent of surgery (mastectomy of the involved gland vs unilateral or bilateral mastectomy) did not appear to influence the outcome of the disease, and metastasis to regional lymph nodes did not appear to be a reliable prognostic indicator.
The reaction between ovarian hormones and experimental uterine infection (Streptococcus zooepidemicus) was investigated in 3 groups, each containing 6 ovariectomized mares. Group 1 served as controls ('anoestrus'), Group 2 mares were injected with oestrogen ('oestrus') and Group 3 with progesterone ('dioestrus') over a period of 5 weeks. All mares received an intrauterine inoculation of the bacteria 1 week after the start of hormonal treatment, and the results of the challenge were examined by endometrial biopsy and swabs once weekly. At the end of Week 1 no bacteria were recovered from the mares in Group 2. Group 1 mares were free of bacteria at the end of Week 2 but all Group 3 mares remained infected at least for the total period examined. Streptococcal phagocytosis was quantitated by chemiluminescence. Before the challenge-inoculation, phagocytosis was not significantly different in the 3 groups of mares. Bacterial cultures were negative for all three groups. However, within 48 h after infection, there was a significant increase (P less than 0.01) in phagocytosis in Group 2 and a significant suppression (P less than 0.05) in Group 3 mares. Patterns of streptococcal clearance from the uterus closely paralleled the changes in the magnitude of chemiluminescence response. The results suggest that ovarian hormonal status can modulate the phagocytic response in episodes of streptococcal-induced endometritus in mares.
