Kanella Zerva

University of Zagreb

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Co-Authors

John Barbetseas

Laiko General Hospital of Athens

Elias Sanidas

Laiko General Hospital of Athens

Marina Mantzourani

National and Kapodistrian University of Athens

Maria Velliou

University General Hospital Attikon

ΜB

Μaria Bonou

Laiko General Hospital of Athens

Jacob Strahilevitz

Hadassah Medical Center

Dan Gilon

Hadassah Medical Center

Kamila Fernanda Staszko

National University Heart Centre Singapore

Shabnam Boudagh

Iran University of Medical Sciences

Reynaldo André Brandt

Hospital Israelita Albert Einstein

Cooperative Institutions

Association Française pour le Dépistage et la Prévention des Handicaps de l’Enfant

340

University of Liège

333

Shaheed Rajaei Cardiovascular Medical and Research Center

289

Associazione Nazionale Medici Cardiologi Ospedalieri

270

Institut de Recherche pour le Développement

230

Méditerranée Infection Foundation

228

Maria Cecilia Hospital

220

Erasmus MC

135

University of Leeds

134

Erasmus University Rotterdam

131

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An e-learning platform for managing seafarers’ health issues on board: pilot use on the Greek shipping industry

International Journal of Community Medicine and Public Health (2022)

Kanella Zerva Aikaterini Drylli Aristeidis Chrysovergis Georgios Chrysovitsiotis Efthymios Kyrodimos

Background: It is well known that health management on board is a major challenge for maritime authorities, shipping companies, and seafarers. This paper presents the outcomes of the pilot use of an e-learning platform for dealing with mariners’ health issues aboard.Methods: The survey took place in the Piraeus port (Attica, Greece) during November 2021-February 2022. Data were gathered from merchant ship mariners (n=41) by questionnaires at the Piraeus port, Athens, Greece. A descriptive statistical analysis was performed by the SPSS v23.0® and Microsoft excel© 365.Results: Twenty-one seafarers (51.21%) were at the age group 31-40 years old, fifteen (36.58%) were at the age group 41-50 years old, four (9.75%) were at the age group 51-60 years old and 1 participant (2.43%) was over 60 years old. Twenty-six (63.41%) of the participants were occupied on deck department while fifteen (36.58%) in the engine room. A statistically significant higher score on web-test after the use of SeaHealth platform was confirmed by paired t test (p<0.001) (Figure 3).Conclusions: The participants who used the e-learning platform improved their knowledge on first aid, increased their basic skills on medical care, and achieved more confidence in handling emergencies effectively aboard.

Microsoft excel

Port (circuit theory)

On board

10.18203/2394-6040.ijcmph20221003

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Citations (1)

Correction to: Surgery and outcome of infective endocarditis in octogenarians: prospective data from the ESC EORP EURO-ENDO registry

Infection (2022)

Michal Pazderník Bernard Iung Bülent Mutlu François Alla Robert K. Riezebos

Infective Endocarditis

10.1007/s15010-022-01883-y

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Citations (0)

Right heart thrombus causing syncope in an elderly patient

Age and Ageing (2015)

Eva D. Papadimitraki Dimitrios Papadopoulos Kanella Zerva Dimitrios Bassoulis Evangelos Chatzigheorgiou

Pulmonary embolism and thromboembolic disease carry a high mortality if not recognised and managed appropriately. Herein we illustrate the case of a dehydrated elderly female patient with recurrent syncope who proved to have high risk pulmonary embolism and a free floating right heart thrombus. The echocardiographic findings of right heart thrombus and possible thrombi ‘in transit’ within a low flow inferior vena cava, guided a life-saving treatment in this frail elderly patient.

Right heart

10.1093/ageing/afv092

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Citations (1)

Effect of thrombolytic therapy in plaque inflammation and structural remodeling in acute myocardial infarction patients

Hellenic Journal of Cardiology (2017)

Kanella Zerva Elias Sanidas Georgios Tzanis Vasiliki Chantziara Dimitris Papadopoulos

Ventricular remodeling

10.1016/j.hjc.2017.06.002

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Citations (6)

Is epistaxis associated with arterial hypertension? A systematic review of the literature

European Archives of Oto-Rhino-Laryngology (2013)

Dimitrios Kikidis Konstantinos Tsioufis Vasileios Papanikolaou Kanella Zerva Anastasios G Hantzakos

10.1007/s00405-013-2450-z

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Citations (72)

THE IMPACT OF ADIPOKINES IN THE ONSET OF ATRIAL FIBRILLATION

Journal of Hypertension (2021)

Dimitrios Papadopoulos Elias Sanidas Maria Velliou Konstantinos Tsakalis Kanella Zerva

Objective: Several adipose tissue bioactive factors (adipokines) have been linked to cardiovascular (CV) diseases. Apelin and omentin-1 have cardioprotective effects whereas visfatin and chemerin have negative effects on CV function. The aim of this study was to calculate apelin, omentin-1, visfatin and chemerin plasma levels in patients with a first episode of atrial fibrillation (AF) investigating any potential association of these factors with the presence of the arrhythmia. Design and method: Overall, 60 patients without a previous history of AF were studied. Of them, 30 had a first documented episode of AF on ECG or 24-hour Holter monitoring during the last month and 30 did not. Apelin, omentin-1, visfatin and chemerin plasma levels were measured by the Elisa method. Results: Compared to non-AF patients, visfatin and chemerin levels were higher in patients with a first episode of AF while apelin and omentin-1 levels were lower. However, statistically significant differences were observed only for apelin and visfatin. No statistically significant differences in demographic characteristics and CV risk factors were noted between the two groups (Table). Conclusions: Visfatin as a non-cardioprotective adipokine was increased in patients having AF for the first time while apelin as a cardioprotective adipokine was decreased indicating a potential correlation of these hormones with the presence of the arrhythmia.

Chemerin

Apelin

10.1097/01.hjh.0000745364.98329.34

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THE ROLE OF APELIN IN NEWLY DIAGNOSED PATIENTS WITH HYPERTENSION

Journal of Hypertension (2019)

Kanella Zerva D.P. Papadopoulos Elias Sanidas K. Tsakalis Maria Velliou

Objective: The role of adipose tissue as an endocrine organ has been linked to many cardiovascular diseases. Apelin is an adipokine, which is mainly produced in adipose tissue, increases cardiac output, lowers blood pressure, and attenuates oxidative stress and hypertrophy. However, the exact impact of apelin in newly diagnosed hypertensive patients, without any other concomitant cardiovascular disease, remains unclear. Design and method: Overall, 50 newly diagnosed patients with arterial hypertension and without any other cardiovascular disease and 25 control subjects with no difference regarding age, gender and body mass index were studied. Apelin plasma levels were measured by the Elisa method. Results: Apelin plasma levels were significantly lower (140.89 ± 52.4 pg/ml vs 295.2 ± 96.3 pg/ml) in patients with arterial hypertension compared to controls. Conclusions: Reduced apelin levels were observed in patients with newly diagnosed arterial hypertension indicating a potential role as independent prognostic factors for this condition.

Apelin

Concomitant

10.1097/01.hjh.0000571844.82099.43

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The ESC-EORP EURO-ENDO (European Infective Endocarditis) registry

European Heart Journal - Quality of Care and Clinical Outcomes (2019)

Gilbert Habib Patrizio Lancellotti P A Erba Anita Sadeghpour Marwa Sayed Meshaal

Abstract Aims The European Society of Cardiology (ESC) EURObservational Research Programme (EORP) European Endocarditis (EURO-ENDO) registry aims to study the care and outcomes of patients diagnosed with infective endocarditis (IE) and compare findings with recommendations from the 2015 ESC Clinical Practice Guidelines for the management of IE and data from the 2001 Euro Heart Survey. Methods and results Patients (n = 3116) aged over 18 years with a diagnosis of IE based on the ESC 2015 IE diagnostic criteria were prospectively identified between 1 January 2016 and 31 March 2018. Individual patient data were collected across 156 centres and 40 countries. The primary endpoint is all-cause mortality in hospital and at 1 year. Secondary endpoints are 1-year morbidity (all-cause hospitalization, any cardiac surgery, and IE relapse), the clinical, epidemiological, microbiological, and therapeutic characteristics of patients, the number and timing of non-invasive imaging techniques, and adherence to recommendations as stated in the 2015 ESC Clinical Practice Guidelines for the management of IE. Conclusion EURO-ENDO is an international registry of care and outcomes of patients hospitalized with IE which will provide insights into the contemporary profile and management of patients with this challenging disease.

Infective Endocarditis

Clinical endpoint

Clinical Practice

10.1093/ehjqcco/qcz018

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Citations (68)

THE ROLE OF STATIN THERAPY IN ADIPOSE TISSUE

Journal of Hypertension (2021)

Elias Sanidas D. Papadopoulos Maria Velliou Kanella Zerva Konstantinos Tsakalis

Objective: The hormones of adipose tissue, so called adipokines, possess either anti-inflammatory (apelin) or pro-inflammatory (chemerin) properties affecting local and systemic inflammation. Nonetheless, statins have potent anti-inflammatory effects in tissues and organs contributing to favorable outcomes. The aim of this study was to calculate apelin and chemerin adipokines plasma levels in patients with impaired lipid levels receiving statins exploring another potential pleotropic impact of statin therapy. Design and method: Overall, 127 patients were studied. Of them, 66 were treated with statins and 61 were not. Apelin and chemerin plasma levels were measured by the Elisa method. Results: Apelin levels were higher in patients treated with statins while chemerin levels were lower. No significant differences in demographic characteristics, arterial hypertension and diabetes mellitus were observed between the two groups (Table). Conclusions: The anti-inflammatory adipokine apelin was increased in patients receiving statins whereas the pro-inflammatory adipokine chemerin was decreased underlining an alternative anti-inflammatory effect of statin therapy.

Chemerin

Apelin

10.1097/01.hjh.0000748152.72894.ab

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The impact of apelin and relaxin plasma levels in masked hypertension and white coat hypertension

Journal of Clinical Hypertension (2018)

Elias Sanidas K. Tsakalis Dimitrios Papadopoulos Kanella Zerva Maria Velliou

Masked hypertension (HTN) and white coat hypertension represent two reverse forms of clinical HTN with questionable prognostic significance. Recent evidence supports that low apelin and relaxin plasma levels contribute to vascular damage accelerating atherogenesis and predisposing to HTN and cardiovascular (CV) events. The aim of this study was to compare apelin and relaxin plasma levels between patients with masked hypertension (MH) and those with white coat HTN (WCH). Overall, 130 patients not receiving antihypertensive therapy were studied. All patients underwent 24‐hour ambulatory BP monitoring (ABPM) and office BP measurements. Plasma apelin and relaxin levels were measured by ELISA method. According to BP recordings, 24 subjects had MH (group A) and 32 had WCH (group B). Apelin (200 ± 111 pg/mL vs 305 ± 127 pg/mL, P < 0.01) and relaxin (35.2 ± 6.7 pg/mL vs 46.8 ± 23.6 pg/mL, P < 0.01) plasma levels were significantly lower in patients with MH compared to those with WCH, respectively. In conclusion, our findings showed that patients with MH had significantly lower apelin and relaxin levels compared to those with WCH. This observation implies an additional prognostic role for adipokines supporting the concept that MH is closer to essential HTN whereas WCH is a more benign condition.

White coat hypertension

Apelin

Relaxin

Masked Hypertension

10.1111/jch.13449

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Citations (8)