Wenkang Tu

Yanshan University

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Karolina Adrjanowicz

Institute of Physics

Li‐Min Wang

Tianjin University of Commerce

Katarzyna Chat

University of Silesia in Katowice

Xuwu Zhang

Yanshan University

Yuchu He

State Key Laboratory of Metastable Materials Science and Technology

Zeming Chen

Heilongjiang Academy of Sciences

Marian Paluch

Institute of Physics

Dawei Gao

Yanshan University

ŁL

Łukasz Laskowski

Institute of Nuclear Physics, Polish Academy of Sciences

Yanqin Gao

China Academy of Launch Vehicle Technology

Cooperative Institutions

Yanshan University

State Key Laboratory of Metastable Materials Science and Technology

University of Silesia in Katowice

Chinese Academy of Sciences

Institute of Physics

Silesian Center for Heart Disease

University of Chinese Academy of Sciences

Zhejiang University

Sun Yat-sen University

Shanghai Jiao Tong University

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Piezoelectric Catalysis Induces Tumor Cell Senescence to Boost Chemo‐Immunotherapy

Small (2024)

Zining Hao Shu Guo Wenkang Tu Qiang Wang Jing Wang

Abstract Cellular senescence, a vulnerable state of growth arrest, has been regarded as a potential strategy to weaken the resistance of tumor cells, leading to dramatic improvements in treatment efficacy. However, a selective and efficient strategy for inducing local tumor cellular senescence has not yet been reported. Herein, piezoelectric catalysis is utilized to reduce intracellular NAD + to NADH for local tumor cell senescence for the first time. In detail, a biocompatible nanomedicine (BTO/Rh‐D@M) is constructed by wrapping the piezoelectric BaTiO 3 /(Cp * RhCl 2 ) 2 (BTO/Rh) and doxorubicin (DOX) in the homologous cytomembrane with tumor target. After tumors are stimulated by ultrasound, negative and positive charges are generated on the BTO/Rh by piezoelectric catalysis, which reduce the intracellular NAD + to NADH for cellular senescence and oxidize H 2 O to reactive oxygen species (ROS) for mitochondrial damage. Thus, the therapeutic efficacy of tumor immunogenic cell death‐induced chemo‐immunotherapy is boosted by combining cellular senescence, DOX, and ROS. The results indicate that 23.9% of the piezoelectric catalysis‐treated tumor cells senesced, and solid tumors in mice disappeared completely after therapy. Collectively, this study highlights a novel strategy to realize cellular senescence utilizing piezoelectric catalysis and the significance of inducing tumor cellular senescence to improve therapeutic efficacy.

Senescence

10.1002/smll.202309487

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Citations (8)

Free-radical polymerization of 2-hydroxyethyl methacrylate (HEMA) supported by a high electric field

Polymer Chemistry (2022)

Wenkang Tu Paulina Maksym Kamil Kamiński Katarzyna Chat Karolina Adrjanowicz

Polymerization supported by a high dc voltage results in charged macromolecules with high conductivity, reduced molecular weight, and moderate dispersity.

Dispersity

10.1039/d2py00320a

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Citations (10)

Effect of Surface Modification on the Glass Transition Dynamics of Highly Polar Molecular Liquid S-Methoxy-PC Confined in Anodic Aluminum Oxide Nanopores

The Journal of Physical Chemistry (2019)

Katarzyna Chat Wenkang Tu Łukasz Laskowski Karolina Adrjanowicz

In the presence of nanoscale confinement, the role of surface effects come to the fore in determining the glass-transition dynamics of the molecular liquids and polymers. Therefore, by playing with the surface chemistry it is possible to understand better the mechanism which governs the behavior of glass-forming systems at the nanoscale. In this work, we have combined dielectric and calorimetric data to study surface and confinement effects for highly polar glass-forming liquid S-Methoxy-PC constrained within anodic aluminum oxide membranes of different pore sizes. The inner surface of the pores was modified either by silanization or atomic layer deposition (ALD) coatings. For the tested substance in native nanopores, we have observed two glass transition events in the calorimetric response accompanied by a characteristic deviation of the temperature dependence of the α-relaxation time from the Vogel–Fulcher–Tamman law. We found that depending on the hydrophobicity of the ALD layer the glass transition temperature of the interfacial layer tends to decrease, the α-relaxation peak broadens, and the molecular mobility slows down compared to the native pores. These changes are more visible with increasing hydrophobicity of the surface. Silanization was also found to eliminate at least partially the effects caused by nanopore confinement. However, in this study the most pronounced effects were observed only for pores with large diameters.

Silanization

Nanopore

Source

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Production of ultra-low radioactivity NaI(Tl) crystals for Dark Matter detectors

arXiv (Cornell University) (2019)

Y. Zhu Shuyang Yue Z. W. Ge Yujie Zhu Xiangwei Yin

Scintillating NaI(Tl) crystals are widely used in a large variety of experimental applications. However, for the use as Dark Matter (DM) detectors, such crystals demand a high level of radio-purity, not achievable by means of standard industrial techniques. One of the main difficulties comes from the presence of potassium that always accompanies sodium in alkali halides. On the other hand, the arguable DM detection by DAMA experiment using NaI(Tl) scintillating crystals requires a reliable verification able to either confirm the existence of DM or rule out the DAMA claim. Ultra-low radioactivity NaI(Tl) crystals, particularly with very low potassium content, are therefore indispensable to overcome the current stalemate in Dark Matter searches. Nonetheless, apart from DAMA-LIBRA experiments, to date, no other experiment has succeeded in building a detector from NaI(Tl) crystals with potassium content of ppb level. This work describes recent results in the preparation of ultra-radio-pure NaI(Tl) crystals using a modified Bridgman method. A double-walled platinum crucible technique has been designed and reliability tests show that 5 ppb of potassium in the NaI(Tl) crystals of 2 and 3 inches in diameter can be achieved starting from NaI powder with potassium content of the order of 10 ppb. The potassium excess is segregated in the tail-side of the as grown ingot where measured potassium concentration is above 20 ppb. The purifying effect of Bridgman growth for larger NaI(Tl) crystals is currently being tested. The work also reports on scintillation parameters of our NaI(Tl) crystals measured in a dedicated setup conceived for naked, hygroscopic crystals. The reproducible and reliable production of ultra-low radioactivity NaI(Tl) crystals reported in this work will hopefully spur the construction of new DM search experiments and, anyway, clarify the controversial DAMA-LIBRA results.

Ingot

Crystal (programming language)

Crucible (geodemography)

10.48550/arxiv.1909.11692

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Citations (1)

Anomaly in dielectric relaxation dispersion of glass-forming alkoxy alcohols

The Journal of Chemical Physics (2015)

Yanqin Gao Zeming Chen Wenkang Tu Xiangqian Li Yongjun Tian

The dielectric relaxations in six primary and secondary alkoxy alcohols with varying molecular size and different separation between -O- and hydroxyl group are studied at temperatures around glass transition. The analyses of the apparent full width at half maximum of the main relaxations of the alkoxy alcohols reveal minima in the temperature dependence of the relaxation dispersions. The stretching exponents for the main relaxations of the alkoxy alcohols are also found not to follow the empirical correlations with other dynamic quantities established for generic liquids. A comparison of the relaxation dispersions in the alkoxy alcohols with those in Debye and non-Debye (generic) liquids is presented. The impacts of the β-relaxations on the apparent main relaxation widths are reviewed for molecular glass formers.

Debye

Cole–Cole equation

10.1063/1.4921941

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Citations (14)

Effect of the Surface Polarity, Through Employing Nonpolar Spacer Groups, on the Glass-Transition Dynamics of Poly(phenyl methylsiloxane) Confined in Alumina Nanopores

Macromolecules (2021)

Roksana Winkler Wenkang Tu Mateusz Dulski Łukasz Laskowski Karolina Adrjanowicz

Broadband dielectric spectroscopy and differential scanning calorimetry were used to study the effect of changes in the surface conditions on the segmental dynamics of poly(phenylmethylsiloxane) confined in alumina nanopores. Functionalization was done using highly polar propyl phosphoric units separated by the assumed concentration of triethoxysilane groups (from N = 0 to N = 24). By adjusting the proportion between polar units and nonpolar spacers, it was possible to control the surface polarity. Modification of the surface conditions does not inhibit the formation of the adsorbed layer, as revealed by the presence of two Tg's in calorimetric results. However, changes in the surface polarity will prevent the growth of the additional interlayer in between the core volume and the interfacial layer. Finally, we also found that the changes in the surface polarity affect the equilibration kinetics and can be used to control the time scale of the structural recovery toward the equilibrium state.

Triethoxysilane

Polarity (international relations)

Nanopore

Surface Modification

10.1021/acs.macromol.1c02145

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Citations (8)

Study of Increasing Pressure and Nanopore Confinement Effect on the Segmental, Chain, and Secondary Dynamics of Poly(methylphenylsiloxane)

Macromolecules (2019)

Karolina Adrjanowicz Roksana Winkler Katarzyna Chat Daniel Marques Duarte Wenkang Tu

The effect of increasing pressure and two-dimensional (2D) confinement on the dynamics of glass-forming polymer poly(methylphenylsiloxane) (PMPS) was investigated with the use of dielectric spectroscopy. We demonstrate that the glass-forming polymer confined to nanoporous alumina might obey the density scaling relation similar to that in the bulk and that the same value of the scaling exponent is used to superimpose the α-relaxation time measured under different thermodynamic conditions. Our comprehensive analysis of the relaxation processes detected in the dielectric loss spectra of PMPS allows us to identify the Johari–Goldstein β-relaxation which for a bulk polymer shows up as a well-resolved peak while under 2D nanoconfinement only as an excess wing. In contrast to previous studies, we provide dielectric evidence of an additional α′-relaxation, slower than the segmental (α-) dynamics, which is related to the chain dynamics of PMPS.

Nanoporous

Exponent

Nanopore

10.1021/acs.macromol.9b00473

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Citations (23)

Dynamics of Pyrrolidinium-Based Ionic Liquids under Confinement. II. The Effects of Pore Size, Inner Surface, and Cationic Alkyl Chain Length

The Journal of Physical Chemistry C (2019)

Wenkang Tu Katarzyna Chat Grzegorz Szklarz Łukasz Laskowski K. Grzybowska

In recent years, ionic liquids (ILs) have been developed as novel solvents, electrolytes, and functional materials for numerous applications in diverse fields. Of interest is confining ILs into various nanoporous matrices, which not only solves the drawbacks of ILs due to their fluid nature, for example, electrolyte leakage in batteries, but also endows these systems with distinctly different physicochemical properties relative to the bulk counterparts. In-depth studies on the effect of nanoscale confinement as well as the interactions between ILs and the pore walls should facilitate the development of task-specific IL nanomaterials. Here, using broadband dielectric spectroscopy and differential scanning calorimetry, we have investigated the dynamics and electrical conductivity of pyrrolidinium-based ILs with the bis(trifluoromethanesulfonyl)imide anion ([Tf2N]−), infiltrated into nanoporous anodized aluminum oxide membranes. The effect of pore size, inner surface modification (silanization), and cationic alkyl chain length on properties of confined ILs was examined in detail. For some thermodynamic conditions, we observed much faster dynamics and higher conductivity for the confined IL compared to the bulk case. Thus, our results provide a better understanding of how to tune the conductivity behavior of the ionic system and how to design novel electrochemical nanodevices with tailored-based properties.

Nanoporous

Nanomaterials

10.1021/acs.jpcc.9b10461

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Citations (27)

Energy Engineering in Amorphous Alloys: Harnessing Fictive Temperature for Improved Corrosion Resistance

Liang Yang Zhengqing Cai B.B. Wang Wenkang Tu Yanhui Zhang

10.2139/ssrn.5110101

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Vapor-Deposited Thin Films: Studying Crystallization and α-relaxation Dynamics of the Molecular Drug Celecoxib

The Journal of Physical Chemistry B (2022)

Aparna Beena Unni Roksana Winkler Daniel Marques Duarte Wenkang Tu Katarzyna Chat

Crystallization is one of the major challenges in using glassy solids for technological applications. Considering pharmaceutical drugs, maintaining a stable amorphous form is highly desirable for improved solubility. Glasses prepared by the physical vapor deposition technique got attention because they possess very high stability, taking thousands of years for an ordinary glass to achieve. In this work, we have investigated the effect of reducing film thickness on the α-relaxation dynamics and crystallization tendency of vapor-deposited films of celecoxib (CXB), a pharmaceutical substance. We have scrutinized its crystallization behavior above and below the glass-transition temperature (Tg). Even though vapor deposition of CXB cannot inhibit crystallization completely, we found a significant decrease in the crystallization rate with decreasing film thickness. Finally, we have observed striking differences in relaxation dynamics of vapor-deposited thin films above the Tg compared to spin-coated counterparts of the same thickness.

Deposition

Physical vapor deposition

Celecoxib

10.1021/acs.jpcb.2c01284

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Citations (8)