The title compound, C28H18Cl6, was obtained by the electrolysis of 2,2,2-trichloro-1,1-bis(4-chlorophenyl)ethane (DDT) in the presence of a catalytic amount of the cobalamin derivative heptamethyl cobyrinate perchlorate. The alkene group of the molecule has a Z configuration.
The controlled-potential electrolysis of 1,1-bis(4-chlorophenyl)-2,2,2-trichloroethane (DDT) was carried out at −1.4 V vs. Ag–AgCl in the presence of a hydrophobic vitamin B12, heptamethyl cobyrinate perchlorate. DDT was dechlorinated to form 1,1-bis(4-chlorophenyl)-2,2-dichloroethane (DDD), 1,1-bis(4-chlorophenyl)-2,2-dichloroethylene (DDE), 1-chloro-2,2-bis(4-chlorophenyl)ethylene (DDMU) and 1,1,4,4-tetrakis(4-chlorophenyl)-2,3-dichloro-2-butene (TTDB) (E/Z), and quantitative recovery of the catalyst after the electrolysis was confirmed by electronic spectroscopy. A photo-sensitive intermediate having a cobalt–carbon bond formed during the electrolysis was characterized by electronic spectroscopy. A mechanism for the formation of various dechlorinated products was investigated by using deuterium solvents and various spectroscopic measurements such as UV-VIS and the EPR spin-trapping technique.
A 77-year-old patient was admitted to our hospital for the further examination of melena. A computed tomography scan detected two submucosal tumors (SMTs) in the stomach and jejunum. Double-balloon endoscopy revealed the presence of a delle on the jejunal SMT, suggesting that the SMT was the origin of the gastrointestinal bleeding. Both tumors were surgically resected and subsequently diagnosed via histology as gastrointestinal stromal tumors (GISTs). Furthermore, the two GISTs had different mutations in the c-kit gene, suggesting that they were derived from different clonal origins. This report depicts an extremely rare case of multiple synchronous sporadic GISTs in the stomach and jejunum.
A 47-year-old woman was referred to our hospital with recurring lower abdominal pain persisting for more than 2 weeks. Imaging modalities showed small bowel obstruction caused by a mass lesion in the terminal ileum. Despite undergoing fasting, rehydration, and decompression through an ileus tube, her symptoms persisted. Furthermore, the condition deteriorated on day 4, with the onset of her menstrual period. An emergency surgery was conducted on the 7th day after hospitalization. Surgical observations indicated severe stenosis around the ileocecal valve and ileal perforation approximately 40cm from the oral stricture. As a result, ileocecal resection was performed. Pathological examination revealed endometrial tissue infiltration through the mucosal lamina propria to the ileal subserosa. Thus, the patient was identified with intestinal endometriosis of the ileocecum. Endometriosis of the small bowel is an uncommon condition that eventually causes intractable bowel obstruction. Although preoperative diagnosis is considered challenging, intestinal endometriosis should be included in the differential diagnosis in cases of bowel obstruction in women of childbearing age.
Dechlorination of 1,1-bis(4-chlorophenyl)-2,2,2-trichloroethane (DDT) was catalyzed by a hydrophobic vitamin B12, heptamethyl cobyrinate perchlorate, with a visible light irradiation system containing a [Ru(II)(bpy)3]Cl2 photosensitizer, and the hydrophobic vitamin B12 showed high catalytic efficiency and stability during the reaction.
Hydrophobic vitamin B12 was covalently immobilized onto a platinum electrode surface, and the immobilized complex exhibits Co(II)/Co(I) redox couple and in situ the Co(I) species reacts with phenethyl bromide to form styrene under irradiation with visible light with a turnover number of over 6000 for 1 h.
The title compound, C28H18Cl6, was obtained by the electrolysis of 2,2,2-trichloro-1,1-bis(4-chlorophenyl)ethane (DDT) in the presence of a catalytic amount of a cobalamin derivative. The molecule has a centre of symmetry, and the alkene moiety has an E configuration.
A vitamin B12 derivative, heptapropyl cobyrinate perchlorate, was readily trapped onto an indium tin oxide (ITO) electrode by a sol–gel reaction. The complex was physically retained in a silica gel film which is formed on an ITO electrode. The thickness of the film could be controlled by the withdrawing speed of the dip coating process. Formation of a sol–gel film was confirmed by SEM measurements, and the total amount of the complex in the film was determined by UV–VIS absorption spectra. The complex exhibits the CoII/CoI redox couple at −0.42 V vs. Ag–AgCl. The amount of the electroactive complex in the sol–gel film deduced from electrochemical measurements is 3.0 × 10−11 and 6.2 × 10−11 mol cm−2 for thicknesses of 170 and 330 nm, respectively. This electroactive complex shows a high reactivity towards organic halides, and the controlled-potential electrolysis of benzyl bromide using the sol–gel modified electrode at −1.20 V vs. Ag–AgCl in aqueous solution containing 0.1 M KCl afforded dehalogenated products, bibenzyl and toluene, with a total turnover number of >1000 for 1 h.
