Alice Fialho Viana

Universidade Federal do Rio Grande do Sul

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Stela Maris Kuze Rates

Universidade Federal do Rio Grande do Sul

Gilsane Lino von Poser

Universidade Federal do Rio Grande do Sul

Ana Paula Machado Heckler

Universidade Federal do Rio Grande do Sul

Milene Borsoï

Associated Research (United States)

Eveline Dischkaln Stolz

Universidade Federal do Rio Grande do Sul

Jean Costentin

Académie Nationale de Médecine

Jean‐Claude do Rego

Université de Rouen Normandie

Raquel Fenner

Universidade Federal do Rio Grande do Sul

Gilda Neves

Universidade Federal do Rio de Janeiro

Liz Girardi Müller

Community University of Chapecó Region - Unochapecó

Cooperative Institutions

Universidade Federal do Rio Grande do Sul

Pontifícia Universidade Católica do Rio Grande do Sul

Universidade Federal de Santa Catarina

Universidade Federal do Rio Grande

Centre National de la Recherche Scientifique

Instituto de Ciências Farmacêuticas

Hospital de Clínicas de Porto Alegre

Université de Rouen Normandie

Universidade Federal de Santa Maria

Hospital São Lucas da PUCRS

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Double continuous injection preparation method of cyclodextrin inclusion compounds by spray drying

Chemical Engineering Journal (2013)

Joel J. Passos Frederico B. De Sousa Iram Moreira Mundim Ricardo Rodrigues Bonfim Robson L. Melo

10.1016/j.cej.2013.04.074

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Citations (17)

The Antinociceptive Effect of a Benzopyran (HP1) Isolated fromHypericum polyanthemumin Mice Hot-Plate Test is Blocked by Naloxone

Planta Medica (2010)

Juliana Schulte Haas Alice Fialho Viana Ana Machado Heckler Gilsane Lino von Poser Stela Maris Kuze Rates

Several species of the genus Hypericum (Guttiferae) have been used for analgesic purposes all over the world and some of them have demonstrated to possess this effect in rodents. This study describes the antinociceptive effect of the cyclohexane extract from aerial parts of H. polyanthemum (POL) as well as of benzopyrans, 6-isobutyryl-5,7-dimethoxy-2,2-dimethyl-benzopyran (HP1), 7-hydroxy-6-isobutyryl-5-methoxy-2,2-dimethyl-benzopyran (HP2), and 5-hydroxy-6-isobutyryl-7-methoxy-2,2-dimethyl-benzopyran (HP3), which are the main components of POL. The antinociceptive effect was evaluated through hot-plate and writhing tests in mice, and the opioid system involvement was assessed by using naloxone (2.5 mg/kg, s. c.) antagonism. In the hot-plate test, POL (45, 90, 180 mg/kg, p.o) showed a dose-dependent effect, and out of the benzopyrans only HP1 (30, 60, 90 mg/kg, i. p.) was active. Its effect was also dose-dependent, with the maximum reached at 60 mg/kg. HP1 60 mg/kg (p. o.) also inhibited acetic acid-induced writhing in 58 %. The pretreatment with naloxone abolished the antinociceptive effect of HP1 60 mg/kg (i.p) in the hot plate. Furthermore, the H. polyanthemum cyclohexane extract and HP1 did not affect the mice performance in the rota-rod apparatus suggesting that at antinociceptive doses they do not present gross neurotoxicity nor induce motor impairment. From these data it is reasonable to assume that the benzopyran HP1 accounts for the H. polyanthemum cyclohexane extract antinociceptive effect, and this effect is, at least in part, mediated by an opioid-like mechanism.

Hot plate test

Benzopyrans

10.1055/s-0029-1240942

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Citations (24)

Síntese e ensaio in vivo de ésteres da indometacina: desenvolvimento de aula prática em Química Medicinal para alunos de pós-graduação

Latin American Journal of Pharmacy (2008)

Letícia Cruz Cedric Stephan Graebin Alice Fialho Viana Ângelo L. S. Piato Daniela Dal Molim Ghisleni

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Monoamine oxidase inhibitory activity of some Hypericum species native to South Brazil

Journal of Pharmacy and Pharmacology (2001)

Carmela Gnerre Gilsane Lino von Poser Alexandre de Barros Falcão Ferraz Alice Fialho Viana Bernard Testa

The total methanol crude extracts and petroleum ether, chloroform, and methanol fractions obtained from Hypericum species, H. caprifoliatum, H. carinatum, H. connatum, H. cordatum, H. myrianthum, H. piriai, H. polyanthemum and H. brasiliense, all native to South Brazil, were assayed for monoamine oxidase A (MAO A) and MAO B inhibitory activity in rat brain mitochondrial preparations at concentrations ranging from 1 to 20microg mL(-1). Three benzopyrans, HP1 (6-isobutyryl-5,7-dimethoxy-2,2-dimethylbenzopyran), HP2 (7-hydroxy-6-isobutyryl-5-methoxy-2,2-dimethylbenzopyran) and HP3 (5-hydroxy-6-isobutyryl-7-methoxy-2,2dimethylbenzopyran) isolated from H. polyanthemum were also tested at maximal concentrations of 150, 150 and 75/microM, respectively. The lipophilic extracts of H. polyanthemum, H. caprifoliatum and H. piriai displayed MAO A inhibitory activity greater than 50%. Among the benzopyrans, only HP3 showed significant activity, with an IC50 value of 22 microM. The total methanol crude extracts of aerial parts from H. carinatum, H. connatum, H. cordatum, H. polyanthemum and H. piriai were evaluated for antidepressant activity in the Porsolt's forced swimming test in Wistar rats (270 mg kg(-1) day(-1); i.p); however, none of them showed activity.

Hypericum

IC50

10.1211/0022357011776568

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Citations (49)

Comparisons between anxiety tests for selection of anxious and non anxious mice.

HAL (Le Centre pour la Communication Scientifique Directe) (2006)

J.-C. Do-Rego Alice Fialho Viana Erwan Le Maître Audrey Deniel Stela Maris Kuze Rates

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Dopaminergic profile of new heterocyclic N-phenylpiperazine derivatives

Brazilian Journal of Medical and Biological Research (2003)

Gilda Neves Raquel Fenner Ana Paula Machado Heckler Alice Fialho Viana Leandro Tasso

Dopamine constitutes about 80% of the content of central catecholamines and has a crucial role in the etiology of several neuropsychiatric disorders, including Parkinson's disease, depression and schizophrenia. Several dopaminergic drugs are used to treat these pathologies, but many problems are attributed to these therapies. Within this context, the search for new more efficient dopaminergic agents with less adverse effects represents a vast research field. The aim of the present study was to report the structural design of two N-phenylpiperazine derivatives, compound 4: 1-[1-(4-chlorophenyl)-1H-4-pyrazolylmethyl]-4-phenylhexahydropyrazine and compound 5: 1-[1-(4-chlorophenyl)-1H-1,2,3-triazol-4-ylmethyl]-4-phenylhexahydropyrazine, planned to be dopamine ligands, and their dopaminergic action profile. The two compounds were assayed (dose range of 15-40 mg/kg) in three experimental models: 1) blockade of amphetamine (30 mg/kg, ip)-induced stereotypy in rats; 2) the catalepsy test in mice, and 3) apomorphine (1 mg/kg, ip)-induced hypothermia in mice. Both derivatives induced cataleptic behavior (40 mg/kg, ip) and a hypothermic response (30 mg/kg, ip) which was not prevented by haloperidol (0.5 mg/kg, ip). Compound 5 (30 mg/kg, ip) also presented a synergistic hypothermic effect with apomorphine (1 mg/kg, ip). Only compound 4 (30 mg/kg, ip) significantly blocked the amphetamine-induced stereotypy in rats. The N-phenylpiperazine derivatives 4 and 5 seem to have a peculiar profile of action on dopaminergic functions. On the basis of the results of catalepsy and amphetamine-induced stereotypy, the compounds demonstrated an inhibitory effect on dopaminergic behaviors. However, their hypothermic effect is compatible with the stimulation of dopaminergic function which seems not to be mediated by D2/D3 receptors.

Catalepsy

Stereotypy

Apomorphine

10.1590/s0100-879x2003000500010

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Citations (38)

Antinociceptive Activity ofTrichilia catiguaHydroalcoholic Extract: New Evidence on Its Dopaminergic Effects

Evidence-based Complementary and Alternative Medicine (2009)

Alice Fialho Viana Izaque de Sousa Maciel Emerson Marcelo Motta Paulo César Leal Luiz F. Pianowski

Trichilia catigua is a native plant of Brazil; its barks are used by some local pharmaceutical companies to prepare tonic drinks, such as Catuama. The present study was addressed to evaluate the effects of T. catigua hydroalcoholic extract in mouse nociception behavioral models, and to evaluate the possible mechanisms involved in its actions. Male Swiss mice were submitted to hot-plate, writhing and von Frey tests, after oral treatment with T. catigua extract (200 mg kg(-1), p.o.). The extract displayed antinociceptive effect in all three models. For characterization of the mechanisms involved in the antinociceptive action of the extract, the following pharmacological treatments were done: naloxone (2.5 mg kg(-1), s.c.), SR141716A (10 mg kg(-1), i.p.), SCH23390 (15 μg kg(-1), i.p.), sulpiride (50 mg kg(-1), i.p.), prazosin (1 mg kg(-1), i.p.), bicuculline (1 mg kg(-1), i.p.) or dl-p-chlorophenylalanine methyl ester (PCPA, 100 mg kg(-1), i.p.). In these experiments, the action of T. catigua extract was evaluated in the hot-plate test. The treatment with SCH23390 completely prevented the antinociceptive effect, while naloxone partially prevented it. The possible involvement of the dopaminergic system in the actions of T. catigua extract was substantiated by data showing the potentiation of apomorphine-induced hypothermia and by the prevention of haloperidol-induced catalepsy. In conclusion, the antinociceptive effects of T. catigua extract seem to be mainly associated with the activation of dopaminergic system and, to a lesser extent, through interaction with opioid pathway.

Catalepsy

Apomorphine

Sulpiride

10.1093/ecam/nep144

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Citations (37)

Hypericum caprifoliatum (Guttiferae) Cham. & Schltdl.: a species native to South Brazil with antidepressant‐like activity

Fundamental and Clinical Pharmacology (2006)

Alice Fialho Viana Jean‐Claude do Rego Leonardo Munari Nathalie Dourmap Ana Paula Machado Heckler

Abstract In this work, previously published and unpublished results on biological activity of Hypericum caprifoliatum , a native specie to South Brazil, are presented. Lipophilic extracts obtained from this species showed an antidepressant‐like activity in mice and rat forced swimming test. Results from in vivo experiments suggest an effect on the dopaminergic transmission. Besides that, in vitro experiments demonstrated that the extract and its main component (a phloroglucinol derivative) inhibit monoamine uptake in a concentration‐dependent manner, more potently to dopamine, but this effect is not related to direct binding at the uptake sites. It was also observed that a 3‐day treatment with lipophilic extract prevents stress‐induced corticosterone rise in mice frontal cortex but not in plasma. The lipophilic and methanolic H. caprifoliatum extracts also demonstrated antinociceptive effect, which seems to be indirectly mediated by the opioid system. These results indicate that H. caprifoliatum presents a promising antidepressant‐like effect in rodents which seems to be related to a mechanism different from that of other classes of antidepressants.

Hypericum

Phloroglucinol

10.1111/j.1472-8206.2006.00440.x

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Citations (19)

Repeated forced swimming impairs prepulse inhibition and alters brain-derived neurotrophic factor and astroglial parameters in rats

Pharmacology Biochemistry and Behavior (2014)

Milene Borsoï Camila B. Antonio Liz Girardi Müller Alice Fialho Viana Vivian Hertzfeldt

10.1016/j.pbb.2014.11.012

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Citations (23)

Avaliação da atividade antinociceptiva de H. polyanthemum Klotzsch ex Reichardt e de H. caprifoliatum Cham & Schledt (Guttiferae)

Ana Paula Machado Heckler Raquel Fenner Michele Patricia Kliemann Gilda Neves Leonardo Munari

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