Yuan‐Yen Chang

Shaanxi Normal University

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Yi‐Chen Chen

National Taiwan University of Science and Technology

Hui‐Wen Lin

Far Eastern Memorial Hospital

Deng‐Jye Yang

National Yang Ming Chiao Tung University

Chin‐Lin Hsu

Chung Shan Medical University Hospital

Meilin Wang

Chung Shan Medical University Hospital

Shang‐Chun Tsou

Chung Shan Medical University

Shih‐Yin Chen

China Medical University

Yi‐Ju Lee

Chung Shan Medical University

Tzu‐Chun Chen

Natera (United States)

Yi‐Ling Lin

National Taiwan University of Science and Technology

Cooperative Institutions

Chung Shan Medical University

Chung Shan Medical University Hospital

China Medical University

National Taiwan University

China Medical University Hospital

National Yang Ming Chiao Tung University

National Chung Hsing University

Shaanxi Normal University

Asia University

Capital Medical University

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Beneficial effects of noni (Morinda citrifolia L.) juice on livers of high-fat dietary hamsters

Food Chemistry (2013)

Yi‐Ling Lin Yuan‐Yen Chang Deng‐Jye Yang Bor‐Show Tzang Yi‐Chen Chen

Chlorogenic Acid

Syrian hamsters

10.1016/j.foodchem.2013.02.035

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Citations (79)

Preventive effects of taurine againstd-galactose-induced cognitive dysfunction and brain damage

Food & Function (2017)

Dom‐Gene Tu Yao-Ling Chang Chung‐Hsi Chou Yi‐Ling Lin Chia‐Chun Chiang

Oxidative stress arising from life processes or environmental influences and its resultant cellular dysfunctions are major causes of neurodegenerative disorders. The objectives of this study were to investigate whether taurine (Tau) can prevent d-galactose-induced cognitive dysfunction and brain oxidative damage. Mice given with Tau supplementation (100 and 400 mg per kg BW per day) spent shorter (p < 0.05) time in searching target in d-galactose (100 mg per kg BW per day) treated mice in a water maze reference memory experiment. Moreover, Tau supplementation extended (p < 0.05) the searching period around the target quadrant in the probe test of the water maze, and neuronal degeneration and nucleus shrinkage in the hippocampus dentate gyrus area of d-galactose treated mice were observed to be attenuated. Tau also downregulated (p < 0.05) expression of the glial fibrillary acidic protein (Gfap) and of the cluster of differentiation marker Cd11b; meanwhile, it strengthened (p < 0.05) antioxidant capacity and lowered (p < 0.05) the accumulation of advanced glycation end-products (AGEs) in the brain. Therefore, Tau could be effective to ameliorate oxidative damage and inflammation in the brain, and apoptosis of brain cells, which further lessen the cognitive dysfunction.

10.1039/c7fo01210a

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Inhibitory Effect of Litchi (Litchi chinensis Sonn.) Flower on Lipopolysaccharide-Induced Expression of Proinflammatory Mediators in RAW264.7 Cells through NF-κB, ERK, and JAK2/STAT3 Inactivation

Journal of Agricultural and Food Chemistry (2014)

Deng‐Jye Yang Yuan‐Yen Chang Hui‐Wen Lin Yi‐Chen Chen Shih‐Han Hsu

Litchi (Litchi chinensis Sonn.) flower ethanolic extract (LFEE) was found to contain five flavanoids [total amount, 102.73 ± 5.50 mg/g of dried extract (gDE)], nine phenolic acids (total amount, 60.31 ± 4.52 mg/gDE), and proanthocyanidin A2 (79.31 ± 2.95 mg/gDE). LFEE was used to evaluate the inhibitory effects on lipopolysaccharide- (LPS-) induced pro-inflammatory mediators in RAW264.7 cells. The results showed that LFEE treatment could suppress the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), the productions of nitric oxide (NO) and prostaglandin E2 (PGE2), and the secretions of pro-inflammatory cytokines [interleukin-1β (IL-1β), IL-6, and tumor necrosis factor α (TNF-α)] in the LPS-mediated RAW264.7 cells. The attenuation of LPS-induced inflammatory responses by LFEE was found to be closely related to the inhibition of the translocation of nuclear factor κB (NF-κB) p50/p65 subunits correlated with suppression of the activation of the inhibitor of κB kinase (IKK) α/β and downregulation of activation of extracellular signal-regulated kinase (ERK) and Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3).

Proinflammatory cytokine

10.1021/jf5003705

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Kaempferol suppresses cell migration through the activation of the ERK signaling pathways in ARPE‐19 cells

Environmental Toxicology (2018)

Hsiang‐Wen Chien Kai Wang Yuan‐Yen Chang Yi‐Hsien Hsieh Nuo‐Yi Yu

Abstract Kaempferol is a flavonoid with anticancer and anti‐metastasis activity in different cancer‐cell lines. However, the underlying mechanisms by which kaempferol acts on human retinal pigment epithelial (ARPE‐19) cells remain unclear. In this study, we demonstrated that kaempferol inhibited migration and invasion in ARPE‐19 cells at non‐toxic dosages. We discovered that kaempferol obviously reduced the enzyme activity and protein expression of matrix metalloproteinase‐2 by increasing the phosphorylated levels of extracellular signal‐regulated kinases 1/2 (ERK1/2) signaling pathways. Additionally, ERK1/2‐specific inhibitor PD98059 significantly reversed kaempferol's inhibitory effects on migration and expression of MMP‐2 in ARPE‐19 cells. Overall, our results are the first to demonstrate that kaempferol is capable of inhibiting cell migration by targeting ERK1/2 signaling in human retinal pigment epithelial cells.

10.1002/tox.22686

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Citations (23)

Effects of antrosterol from Antrodia camphorata submerged whole broth on lipid homeostasis, antioxidation, alcohol clearance, and anti-inflammation in livers of chronic-alcohol fed mice

Journal of Ethnopharmacology (2017)

Yuan‐Yen Chang Yichen Liu Yueh‐Hsiung Kuo Yi‐Ling Lin Yi‐Hsieng Samuel Wu

Homeostasis

10.1016/j.jep.2017.03.003

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Citations (32)

Complexation of Inulin with Proteins, Polysaccharides and Polyphenols: Their Interactions, Applications and Health Benefits

Food Reviews International (2025)

Yuan‐Yen Chang Tiantian Lin Mengyan Zhu Shuhuai Yu

Health Benefits

10.1080/87559129.2025.2456544

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Suppressive Effect of Tetrahydrocurcumin on Pseudomonas aeruginosa Lipopolysaccharide-Induced Inflammation by Suppressing JAK/STAT and Nrf2/HO-1 Pathways in Microglial Cells

Oxidative Medicine and Cellular Longevity (2022)

Hui‐Wen Lin Tzu‐Chun Chen Jui‐Hsuan Yeh Shang‐Chun Tsou Inga Wang

Brain inflammation, a pathological feature of neurodegenerative disorders, exhibits elevated microglial activity and increased levels of inflammatory factors. The present study was aimed at assessing the anti-inflammatory response of tetrahydrocurcumin (THC), the primary hydrogenated metabolite of curcumin, which was applied to treat Pseudomonas aeruginosa (P.a.) lipopolysaccharide- (LPS-) stimulated BV2 microglial cells. THC reduced P.a. LPS-induced mortality and the production of inflammatory mediators IL-6, TNF-α, MIP-2, IP-10, and nitrite. A further investigation revealed that THC decreased these inflammatory cytokines synergistically with JAK/STAT signaling inhibitors. THC also increased Nrf2/HO-1 signaling transduction which inhibits iNOS/COX-2/pNFκB cascades. Additionally, the presence of the HO-1 inhibitor Snpp increased the levels of IP-10, IL-6, and nitrite while THC treatment reduced those inflammatory factors in P.a. LPS-stimulated BV2 cells. In summary, we demonstrated that THC exhibits anti-inflammatory activities in P.a. LPS-induced inflammation in brain microglial cells by inhibiting STAT1/3-dependent NF-κB activation and inducing Nrf2-mediated HO-1 expression.

10.1155/2022/4978556

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Citations (13)

Stress-activated neuronal ensemble in the supramammillary nucleus stores anxiety but not memory

bioRxiv (Cold Spring Harbor Laboratory) (2025)

Jinming Zhang Kexin Yu Junmin Zhang Yuan‐Yen Chang Xiao Sun

Anxiety is a very common negative emotional status induced by stress. However, its underlying neural mechanism is still largely unknown. Here, we found a hypothalamic section named the supramammillary nucleus (SuM), which is taking control of anxiety. We then characterized a small ensemble of stress-activated neurons and recruited encoding anxiety. These stress-activated neurons specifically respond to stress, and its activation robustly increases the anxiety-like behavior of mice without significantly influencing fear memory. We then found that the ventral subiculum -SuM but not the dorsal subiculum -SuM projection encodes anxiety and would exhibit an anti-anxiety effect by its inhibition. Our findings extend the understanding of the function of the neuronal engram cells and bring new insights into the studies on emotion especially anxiety.

10.1101/2025.01.15.633288

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Antitumor effects of new-type recombinant interleukin-2.

PubMed (1992)

Xuesheng Feng Xiujuan Zheng Qiusheng Si Yun-Lu Lin Yuan‐Yen Chang

Two new human recombinant interleukin-2 (rIL-2), 125-Ser-rIL-2, and 125-Ala-rIL-2, were generated by protein engineering technique. Both of them maintained the proliferation of natural killer (NK) cells, CTLL-2 cells and their long-term propagations. The mutated new rIL-2 also enhanced the bioactivity of NK cells and the cytotoxicity of tumor-infiltrating lymphocytes (TIL) against the target tumor cells. The above results were all compared with that of the native rIL-2 and a similarity between them was found, which indicates that new type rIL-2 could be used for adoptive immunotherapy of malignant diseases.

Adoptive immunotherapy

Interleukin 15

Lymphokine-activated killer cell

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Prognostic significance of p53 codon 72 polymorphism in lung carcinomas

European Journal of Cancer (1999)

Yi‐Ching Wang H. S. Lee Shin-Hu Chen Yuan‐Yen Chang Cheng–Ying Chen

10.1016/s0959-8049(98)00369-4

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Citations (89)