Introduction: Implant surgery involves local anesthesia and drilling for implant placement, which might influence blood supply of the adjacent tooth. This study evaluated oxygen saturation changes of healthy adjacent tooth with pulse oximetry during implant surgery. Materials and methods: Fifteen healthy adult patients, who were candidate for anterior implant sugary and had at least one healthy anterior adjacent tooth, were selected. Surgery was carried out after lidocaine/epinephrine local anesthesia. At four stages before local anesthesia injection and after injection, oxygen saturation of the healthy adjacent tooth and peripheral oxygen supply were measured. Data was analyzed with paired samples t-test. Results: The mean peripheral blood oxygen saturation before local anesthesia was 98.2%, with no changes during and after surgery. In the teeth the mean of oxygen saturation was 87.73% before local anesthesia, which decreased to 79.27% after surgery, demonstrating a statistically significant difference; at other intervals no significant differences were observed between oxygen saturation values before and after local anesthesia. Conclusion: After local anesthesia injection there was a transient decrease in oxygen saturation in the adjacent tooth. It is not clear whether this decrease in the blood supply of adjacent tooth is clinically important or not; therefore, more studies are necessary. Key words: Dental pulp, Implant, Pulse oximetry.