Zhanjie Zhang

Huazhong University of Science and Technology

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Kunyu Yang

Huazhong University of Science and Technology

You Qin

Union Hospital

Jielin Wei

Huazhong University of Science and Technology

Liangliang Shi

Hainan University

Guixiang Xiao

Union Hospital

Xiaomeng Zhang

Air Force Medical University

Xingao Xiong

Union Hospital

Jinsong Yang

Union Hospital

Yangming Leng

Huazhong University of Science and Technology

Chengzhang Yang

Huanggang Central Hospital

Cooperative Institutions

Huazhong University of Science and Technology

157

Union Hospital

133

Zhejiang University

Union Hospital

Wuhan Union Hospital

Chinese Academy of Sciences

Shanghai Jiao Tong University

Chinese Academy of Medical Sciences & Peking Union Medical College

Sun Yat-sen University

Tsinghua University

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Irradiated tumour cell-derived microparticles upregulate MHC-I expression in cancer cells via DNA double-strand break repair pathway

Cancer Letters (2024)

Suke Deng Jiacheng Wang Yan Hu Yajie Sun Yang Xiao

Radiotherapy (RT) is used for over 50% of cancer patients and can promote adaptive immunity against tumour antigens. However, the underlying mechanisms remain unclear. Here, we discovered that RT induces the release of irradiated tumour cell-derived microparticles (RT-MPs), which significantly upregulate MHC-I expression on the membranes of non-irradiated cells, enhancing the recognition and killing of these cells by T cells. Mechanistically, RT-MPs induce DNA double-strand breaks (DSB) in tumour cells, activating the ATM/ATR/CHK1-mediated DNA repair signalling pathway, and upregulating MHC-I expression. Inhibition of ATM/ATR/CHK1 reversed RT-MP-induced upregulation of MHC-I. Furthermore, phosphorylation of STAT1/3 following the activation of ATM/ATR/CHK1 is indispensable for the DSB-dependent upregulation of MHC-I. Therefore, our findings reveal the role of RT-MP-induced DSBs and the subsequent DNA repair signalling pathway in MHC-I expression and provide mechanistic insights into the regulation of MHC-I expression after DSBs.

10.1016/j.canlet.2024.216898

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Citations (3)

Supplementary Table from Neoadjuvant Chemoimmunotherapy for the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma: A Single-Arm Phase 2 Clinical Trial

Zhanjie Zhang Bian Wu Gang Peng Guixiang Xiao Jing Huang

Supplementary Table from Neoadjuvant Chemoimmunotherapy for the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma: A Single-Arm Phase 2 Clinical Trial

Chemoimmunotherapy

Neoadjuvant Therapy

10.1158/1078-0432.22486460.v1

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Magnetic nanoparticle clusters radiosensitise human nasopharyngeal and lung cancer cells after alternating magnetic field treatment

International Journal of Hyperthermia (2015)

Jia Ma Zhiping Zhang Zhanjie Zhang Jing Huang You Qin

Purpose: Heat generated by magnetic nanoparticle clusters (MNCs) in an alternating magnetic field (AMF) can be used for hyperthermia cancer treatment. Here, we have synthesised polyacrylic acid-coated MNCs according to previous report, with the ability to increase particle stability in suspension. Radiosensitisation effects of the MNCs under an AMF were investigated in vitro and in vivo.Materials and methods: MTT assay, flow cytometry, clone formation assay, Western blotting, and a γ-H2AX experiment were used to explore the biocompatibility and radiosensitisation effect of the MNCs and their putative radiosensitisation mechanism. An NCI-H460 mouse xenograft model was used to investigate the anti-tumour effect under an AMF in vivo.Results: The temperature of MNC fluids at different concentrations (200 μg/mL to 2 mg/mL) increased rapidly. The MNCs were endocytosed by the cells and were found to be biocompatible. Hsp70 and caspase-3 were found to be up-regulated upon MNCs under an AMF, radiation, and combination of both treatments. MNCs under an AMF efficiently radiosensitised both CNE-2 cells and NCI-H460 cells. Finally, the tumour inhibition rate after treatment with MNCs under an AMF and radiation was significantly higher than that after either treatment alone. The mechanism of radiosensitisation putatively involves inhibition of DNA repair and induction of apoptosis.Conclusions: The MNC fluids under an AMF enhanced the radiosensitivity of tumour cells both in vitro and in vivo.

MTT assay

Radiosensitivity

10.3109/02656736.2015.1063168

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Citations (11)

Rethinking Diffusion Model for Multi-Contrast MRI Super-Resolution

2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR) (2024)

Guangyuan Li Chen Rao Juncheng Mo Zhanjie Zhang Wei Xing

10.1109/cvpr52733.2024.01080

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Citations (6)

Data for "Dependence of Convective Cloud Properties and Their Transport on Cloud Fraction and GCM Resolution Diagnosed from a Cloud-Resolving Model Simulation"

Zenodo (CERN European Organization for Nuclear Research) (2022)

Zhanjie Zhang Guang J. Zhang

The datasets for the manuscript "Dependence of Convective Cloud Properties and Their Transport on Cloud Fraction and GCM Resolution Diagnosed from a Cloud-Resolving Model Simulation". model: WRF3.1.1 location: Southern Great Plains time: from 2100 UTC 23 May to 0600 UTC 24 May time interval: 6 minutes domain size: 512km x 512km vertical layer: 500hpa variables: P, PB, PH, PHB, U, V, W, T, QCLOUD, QICE, QVAPOR calculated data: mse, up_only(only consider updraft), up_down(consider both updrafts and downdrafts)

Cloud fraction

Fraction (chemistry)

10.5281/zenodo.6873456

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Irradiated tumor cell–derived microparticles mediate tumor eradication via cell killing and immune reprogramming

Science Advances (2020)

Chao Wan Yajie Sun Yu Tian Lisen Lu Xiaomeng Dai

By mimicking the RIBE machinery, we provided an indirect radiotherapy approach based on RT-MP for eradication of MPE in mice.

Reprogramming

10.1126/sciadv.aay9789

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Citations (184)

Half-life determination of inorganic-organic hybrid nanomaterials in mice using laser-induced breakdown spectroscopy

Journal of Advanced Research (2020)

Yanwu Chu Zhanjie Zhang Qianyuan He Feng Chen Ziqian Sheng

Inorganic or inorganic-organic hybrid nanomaterials have great potential for applications in the biomedical fields. Biological half-life is an essential pharmacokinetic parameter for these materials to function

Laser-induced breakdown spectroscopy

Nanomaterials

10.1016/j.jare.2020.05.001

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Citations (30)

Secretariat DCABES 2020

Zhanjie Zhang Shipeng Zhang

Provides a listing of current committee members and society officers.

Listing (finance)

10.1109/dcabes50732.2020.00009

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A Bayesian network meta-analysis of the primary definitive therapies for locoregionally advanced nasopharyngeal carcinoma: IC+CCRT, CCRT+AC, and CCRT alone

PLoS ONE (2022)

Zhanjie Zhang Liangliang Shi Xiaohua Hong Bo‐Ya Xiao Guo‐He Lin

Background The major aim of this Bayesian network analysis was to determine the optimal treatment strategy for locoregionally advanced nasopharyngeal carcinoma (LANPC). Method We systematically searched databases and extracted data from randomized clinical trials involving LANPC patients randomly assigned to receive induction chemotherapy followed by concurrent chemoradiotherapy (IC+CCRT), CCRT followed by adjuvant chemotherapy (CCRT+AC), or CCRT. Results In the network analysis, IC+CCRT was significantly better than CCRT alone for 5-year FFS (odds ratio [OR]: 1.63, 95% credible interval [CrI] 1.16–2.29), DMFS (OR: 1.56, 95% CrI 1.08–2.22), and LFRS (OR: 1.62, 95% CrI 1.02–2.59), but not OS (OR: 1.35, 95% CrI 0.92–2.00). Rank probabilities showed that IC+CCRT was ranked the best followed by CCRT+AC and CCRT for all 5-year outcomes. Although compared to IC+CCRT and CCRT, CCRT+AC did not significantly improve survival but had the highest 5-year survival rates. Conclusions IC+CCRT could be recommended as a front-preferred primary definitive therapy for patients with LANPC.

Induction chemotherapy

Chemoradiotherapy

10.1371/journal.pone.0265551

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Citations (3)

Supplementary Table from Neoadjuvant Chemoimmunotherapy for the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma: A Single-Arm Phase 2 Clinical Trial

Zhanjie Zhang Bian Wu Gang Peng Guixiang Xiao Jing Huang

Supplementary Table from Neoadjuvant Chemoimmunotherapy for the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma: A Single-Arm Phase 2 Clinical Trial

Chemoimmunotherapy

Neoadjuvant Therapy

10.1158/1078-0432.22486463.v1

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Citations (0)