Lucía García-Huete

Bellvitge University Hospital

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A. Sabaté

Bellvitge University Hospital

Fernando Juárez

Universidad del Rosario

A. Dalmau

Bellvitge University Hospital

Antoni Rafecas

Hospital Clínic de Barcelona

Juan Figueras

Southwest Washington Medical Center

Maylin Koo

Universitat de Barcelona

Salvador Gil‐Vernet

Bellvitge University Hospital

Pascual Parrilla

Hospital Universitario Virgen de la Arrixaca

Luisa Corral

Bellvitge University Hospital

Andreu Gabarrós

Bellvitge University Hospital

Cooperative Institutions

Bellvitge University Hospital

Universitat de Barcelona

Institut d'Investigació Biomédica de Bellvitge

Instituto de Salud Carlos III

Universitat Autònoma de Barcelona

Ajuntament de L’Hospitalet

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

Centro de Investigación Biomédica en Red

Spanish Clinical Research Network

Vall d'Hebron Hospital Universitari

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Importance of tumoral markers in donors

Transplantation Proceedings (2003)

C. González-Segura Manuel Pascual Rafael Bañares Lucía García-Huete Joan Torrás

10.1016/s0041-1345(03)00693-6

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Citations (8)

Comparative study of antifibrinolytic drugs in orthotopic liver transplantation

Transplantation Proceedings (1999)

A. Dalmau A. Sabaté Fernando Juárez Lucía García-Huete Maylin Koo

Antifibrinolytic

Orthotopic liver transplantation

10.1016/s0041-1345(99)00378-4

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Citations (18)

First CT findings and improvement in GOS and GOSE scores 6 and 12 months after severe traumatic brain injury

Brain Injury (2009)

Luisa Corral J.I. Herrero J. L. Monfort José Luis Ventura Casimiro Javierre

Primary objective: To analyse the association between individual initial computerized tomography (CT) scan characteristics and Glasgow Outcome Scale (GOS) and Extended Glasgow Outcome Scale (GOSE) improvement between 6 months and 1 year.Methods and procedures: Two hundred and twenty-four adult patients with severe traumatic brain injury and Glasgow Coma Scale (GCS) score of 8 or less who were admitted to an intensive care unit were studied. GOS and GOSE scores were obtained 6 and 12 months after injury in 203 subjects. Patients were predominantly male (84%) and median age was 35 years.Main outcomes and results: Traumatic Coma Data Bank (TCDB) CT classification was associated with GOS/GOSE improvement between 6 months and 1 year, with diffuse injury type I, type II and evacuated mass improving more than diffuse injury type III, type IV and non-evacuated mass; for GOS 43/155 (28%) vs 3/48 (6%) (χ2 = 9.66, p < 0.01) and for GOSE 71/155 (46%) vs 7/48 (15%) (χ2 = 15.1, p < 0.01). CT individual abnormalities were not associated with GOS/GOSE improvement, with the exception of subarachnoid haemorrhage, which showed a negative association with GOSE improvement (χ2 = 4.08, p < 0.05).Conclusions: TCDB CT scan classification and subarachnoid haemorrhage were associated with GOS/GOSE improvement from 6–12 months, but individual CT abnormalities were not associated.

Glasgow Outcome Scale

Coma (optics)

10.1080/02699050902788477

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Citations (20)

Tranexamic Acid Reduces Red Cell Transfusion Better than ε-Aminocaproic Acid or Placebo in Liver Transplantation

Anesthesia & Analgesia (2000)

A. Dalmau A. Sabaté Fernando Juárez Lucía García-Huete Maylin Koo

We evaluated the efficacy of the prophylactic administration of ε-aminocaproic acid and tranexamic acid for reducing blood product requirements in orthotopic liver transplantation (OLT) in a prospective, double-blinded study performed in 132 consecutive patients. Patients were randomized to three groups and given one of three drugs prophylactically: tranexamic acid, 10 mg · kg−1 · h−1; ε-aminocaproic acid, 16 mg · kg−1 · h−1, and placebo (isotonic saline). Perioperative management was standardized. Coagulation tests, thromboelastogram, and blood requirements were recorded during OLT and in the first 24 h. There were no differences in diagnosis, Child score, or preoperative coagulation tests among groups. Administration of packed red blood cells was significantly reduced (P = 0.023) during OLT in the tranexamic acid group, but not in the ε-aminocaproic acid group. There were no differences in transfusion requirements after OLT. Thromboembolic events, reoperations, and mortality were similar in the three groups. Prophylactic administration of tranexamic acid, but not ε-aminocaproic acid, significantly reduces total packed red blood cell usage during OLT. Implications In a randomized study of 132 consecutive patients undergoing liver transplantation, we found that tranexamic acid, but not ε-aminocaproic acid, reduced intraoperative total packed red blood cell transfusion.

Aminocaproic acid

Antifibrinolytic

10.1213/00000539-200007000-00006

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Citations (111)

The prophylactic effect of aprotinin on intraoperative bleeding in liver transplantation: A randomized clinical study

Hepatology (1997)

Lucía García-Huete Pere Pascual i Domènech A. Sabaté F Martínez-Brotóns Eduardo Jaurrieta

Fibrinolysis has been recognized as an important cause of intraoperative bleeding during orthotopic liver transplantation (OLT). Several investigators have used prophylactic administration of aprotinin in patients to inhibit fibrinolysis and to decrease transfusion requirements, morbidity, and mortality. Nevertheless, the role of aprotinin in this situation is not yet clear. The goal of this study was to determine the effects of prophylactic administration of aprotinin on intraoperative bleeding and blood requirements, and on hemostatic changes during OLT. Eighty consecutive patients were included in a double-blind, prospective study and were randomized in two groups. In group A (n = 39), an initial dose of 2 × 10 6 kallikrein inactivator units (KIU) of aprotinin was administered in the induction of anesthesia followed by infusion of 5 × 10 5 KIU/h until the end of the procedure. The control group (n = 41) received an identical volume of saline solution. The majority of the operations were performed with vena cava preservation (piggy-back technique) without venovenous bypass. During the anhepatic phase, a significant increase in levels of tissue plasminogen activator, thrombin- antithrombin complexes (TAT) and D-dimers (DD) was noted in both groups. A significant increment of TAT was observed in group A during reperfusion. The remaining hemostatic parameters were similar in both groups. Intraoperative requirements of packed red cells, fresh-frozen plasma (FFP), platelets, and cryoprecipitate were similar in the two groups. Our results suggest that prophylactic administration of aprotinin is not useful in reducing bleeding and blood product requirements during OLT.

Aprotinin

10.1002/hep.510260509

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Citations (91)

Tranexamic Acid Reduces Red Cell Transfusion Better than ε-Aminocaproic Acid or Placebo in Liver Transplantation

Anesthesia & Analgesia (2000)

A. Dalmau A. Sabaté Fernando Juárez Lucía García-Huete Maylin Koo

Aminocaproic acid

Antifibrinolytic

10.1097/00000539-200007000-00006

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Citations (167)

Double kidney transplantation: the importance of the maintenance of possible donors of marginal kidneys

European Journal of Anaesthesiology (2004)

Christophe Marti Lucía García-Huete C. González R. Villalonga Salvador Gil‐Vernet

Martí, C.; Garcia-Huete, L.; González, C.; Villalonga, R.; Gil-Vernet, S.; Riera, L.; Montero, A. Author Information

Garcia

10.1097/00003643-200406002-00637

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Citations (0)

Fatal retroperitoneal gas gangrene complicating colonoscopic polypectomy without bowel perforation in a healthy adult

Endoscopy (2014)

Evelyn Shaw Raquel López Reyes Antònia Bonet Lucía García-Huete Alberto Pasqualetto

Colonoscopy is a commonly performed procedure that is rarely associated with severe complications, especially not life-threatening infections [1] [2] [3]. We report a fatal outcome caused by Clostridium perfringens after colonoscopic polypectomy in a 58-year-old healthy adult. The colonoscopy was performed as part of a public health screening program for colorectal cancer studying fecal occult blood, and during the procedure four polyps were removed.

Polypectomy

Perforation

Clostridium perfringens

Occult

Gangrene

Gas gangrene

Fecal occult blood

10.1055/s-0033-1344990

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Citations (4)

Improvement in GOS and GOSE scores 6 and 12 months after severe traumatic brain injury

Brain Injury (2007)

Luisa Corral José Luis Ventura José Ignacio Herrero J. L. Monfort Montserrat Juncadella

To assess improvements in Glasgow Outcome Scale (GOS) and GOS extended (GOSE) scores between 6 months and 1 year following severe traumatic brain injury (TBI).One studied 214 adult patients with severe TBI with Glasgow Coma Scale (GCS) <9 admitted to Intensive Care Unit (ICU). GOS scores were obtained 6 and 12 months after injury in 195 subjects. Patients were predominantly male (84%) and median age was 35 years.Outcome (GOS and GOSE at 6 months and 1 year) was better in the high GCS score at admission (6-8) group than in the low score group (3-5). The improvement in GOS scores between 6 months and 1 year was greater in the high GCS score at admission group than in the low score group. At 6 months, 75 patients had died and 120 survived. None died between the 6-12-month assessments; at 12 months, 36% had improved GOS score.GOS scores improved between 6-12 months after severe TBI in 36% of survivors and it is concluded that the expectancy of improvement is incomplete at 6 months. This improvement was greater in patients with better GCS scores (6-8) at admission than in those with worse GCS scores (3-5).

Glasgow Outcome Scale

10.1080/02699050701727460

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Citations (57)

Donor Structural and Functional Parameters Are Independent Predictors of Renal Function at 3 Months

Transplantation Proceedings (2007)

Meritxell Ibernón C. González-Segura Francesc Moreso Montserrat Gomà‐i‐Freixanet Daniel Serón

Glomerulosclerosis

10.1016/j.transproceed.2007.06.026

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Citations (14)