Baosong Chen

Institute of Microbiology

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Hongwei Liu

Institute of Subtropical Agriculture

Huanqin Dai

Chinese Academy of Sciences

Junjie Han

Chinese Academy of Sciences

Bao Li

Tsinghua University

Wenzhao Wang

Chinese Academy of Sciences

Jinwei Ren

Institute of Microbiology

Jingzu Sun

Chinese Academy of Sciences

Erwei Li

Chinese Academy of Sciences

Kai Wang

The Seventh Affiliated Hospital of Sun Yat-sen University

Jinjin Zhang

Tianjin Medical University

Cooperative Institutions

Chinese Academy of Sciences

Institute of Microbiology

University of Chinese Academy of Sciences

Shandong University

Chinese Academy of Medical Sciences & Peking Union Medical College

Czech Academy of Sciences, Institute of Microbiology

State Key Laboratory of Microbial Technology

State Key Laboratory of Mycology

Peking University

Huazhong University of Science and Technology

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A concise total synthesis and PPAR activation activity of hericerin from Hericium erinaceum

The Journal of Antibiotics (2020)

Zhongyong Zheng Baosong Chen Kai Wang Bao Li Zhengdi Wang

10.1038/s41429-020-0303-8

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Citations (8)

Discovery of antifungal secondary metabolites from an intestinal fungus Fusarium sp.

The Journal of Antibiotics (2023)

Mingkai Zhang Baosong Chen Huanqin Dai Jingzu Sun Hongwei Liu

Verticillium

Verticillium dahliae

Pathogenic fungus

10.1038/s41429-023-00692-1

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Citations (2)

Antidiabetic action of the Chinese formula Shouhuitongbian and the underlying mechanism associated with alteration of gut microbiota

Phytomedicine (2024)

Tao Wang Huan Liao Jinghan Lin Mingkai Zhang Baosong Chen

Mechanism of Action

Paeoniflorin

10.1016/j.phymed.2024.155575

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Citations (4)

Glyceroglycolipids from the solid culture of Ophiocordyceps sinensis strain LY34 isolated from Tibet of China

Mycology&#58 An International Journal on Fungal Biology (2022)

Baosong Chen Jinghan Lin Ao Xu Dan Yu Dorji Phurbu

Ophiocordyceps sinensis is a well-known entomogenous fungus with its fruiting bodies or cultural mycelium as food and herbal medicines in Asia. While metabolites which could responsible for its potent pharmaceutical effects has long remained to be elucidated. In this work, chemical investigation on the solid culture of O. sinensis strain LY34 led to the discovery of six digalactosyldiacylglycerols (DGDGS, 1-6) including one new. The structure of compound 1 was determined based on the comprehensive spectra analysis, including NMR, MSn, IR, and chemical derivatisation. Bioactivity studies showed a weak cytotoxicity of compounds 1-6 against 293 T cell and medium anti-inflammatory activity of compounds 1 and 2 on Raw 264.7 cell. The discovery of DGDGs in O. sinensis provides new insight into the pharmacologically active substances.

Strain (injury)

10.1080/21501203.2022.2036841

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Citations (1)

Four New Cytotoxic Arborinane-Type Triterpenes from the Endolichenic Fungus Myrothecium inundatum

Planta Medica (2019)

Buddha Bahadur Basnet Li Liu Baosong Chen E. M. Suleimen Haiyang Yu

Abstract Two new arborinane-type triterpenes, myrotheols A (1) and B (2), two new arborinane-type glycosides, myrothesides C (3) and D (4), together with four known diterpenes (5 – 8) were isolated from the ethyl acetate extract of the endolichenic fungus Myrothecium inundatum. The structures of new compounds 1 – 4 were elucidated by NMR and MS analyses. The absolute configuration of 1 was assigned by a single-crystal X-ray diffraction experiment. Compounds 3 and 4 represent the first two natural 4-O-methyl-α-D-mannosides. Compounds 1 – 8 exhibited cytotoxicity against K562 and RKO human cancer cell lines.

Terpene

Cancer cell lines

Absolute Configuration

10.1055/a-0855-4051

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Citations (24)

Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids

Nature Microbiology (2024)

Chang Liu Meng‐Xuan Du Lisheng Xie Wen-Zhao Wang Baosong Chen

Farnesoid X receptor

10.1038/s41564-023-01570-0

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Citations (27)

CCDC 1487771: Experimental Crystal Structure Determination

The Cambridge Structural Database (2016)

Qiaoqiao Tao Ke Ma Yanlong Yang Kai Wang Baosong Chen

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc1ly4m9

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A novel class of α-glucosidase and HMG-CoA reductase inhibitors from Ganoderma leucocontextum and the anti-diabetic properties of ganomycin I in KK-A y mice

European Journal of Medicinal Chemistry (2016)

Kai Wang Bao Li Ke Ma Jinjin Zhang Baosong Chen

10.1016/j.ejmech.2016.11.015

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Citations (97)

Botryane Sesquiterpenoids, Cyclopentadepsipeptides, Xanthones, and Trichothecenes from Trichoderma oligosporum

Planta Medica (2018)

Baosong Chen Erwei Li Li Liu Mingfang Liao Zhaoxiang Zhu

Abstract Five new botryane sesquiterpenes (1–5), one new cyclopentadepsipeptide (9), and two new xanthones (11 – 12), together with 11 known compounds, were isolated from Trichoderma oligosporum. The structures of the new compounds were identified by comprehensive spectroscopic methods including nuclear magnetic resonance and mass spectrometry. The cytotoxicity of 1–19 was evaluated against K562, A549, and ASPC cell lines. Compounds 5, 8, 11, 17, and 18 showed cytotoxicity against the K562 cell line with more than 50% inhibition at 12.5 µM. As to A549 cell line, compound 8 showed the strongest cytotoxicity with approximately 50% inhibition at 25.0 µM. No compounds showed cytotoxicity against the ASPC cell line.

10.1055/a-0593-6030

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Citations (9)

Identification and α-Glucosidase Inhibitory Activity of Meroterpenoids from Hericium erinaceus

Planta Medica (2020)

Baosong Chen Junjie Han Bao Li Wenzhao Wang Ke Ma

Abstract Hericium erinaceus is a very popular edible and medicinal mushroom used for the treatment of enervation and gastrointestinal diseases in Eastern Asia. Chemical investigation on the fruiting body of Hericium erinaceus led to the isolation of 4 new (1 – 4) and 10 known meroterpenoids (5 – 14). The structures of new compounds were determined via analysis of NMR and MS data in combination with chemical derivatization. The inhibitory activities of 1 – 14 against α-glucosidase were evaluated using p-nitrophenyl-α-D-glucopyranoside, sucrose, or maltose as substrate. Compounds 6, 9, 11 – 13 were demonstrated to show the α-glucosidase inhibitory activities. This work confirms the potential of H. erinaceus in the treatment of diabetes.

Hericium erinaceus

Identification

10.1055/a-1146-8369

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Citations (12)