Toshio Mitomi

Tokai University

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[Immunosuppressive acidic glycoprotein (IAP) and immunosuppressive substance].

PubMed (1983)

Kyoji Ogoshi Y Kondoh Hisao Nakasaki T Tajima Toshio Mitomi

Serum IAP and IS levels were studied in patients with stomach cancer. We found that the serum levels of IAP and IS increased as the disease progressed; their true positive rates as tumor markers were 49.3% and 39.8%, respectively. There was some delicate difference between these glycoproteins and T-cell subpopulation. IAP and IS correlated well with a correlation coefficient of 0.847, their value in clinical oncology are thought to be equivalent. Some difference was found between their substances and ASP, this might indicate the heterogeneous nature of the circulating glycoproteins in varying cancer-bearing status.

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Citations (9)

Comparison Between the Lengths of the Colon and Rectum During Operation and After Excision.

Nihon Daicho Komonbyo Gakkai Zasshi (1995)

S. Sakahiro T Noto Tomihiko Kimura N Tokunaga Hideharu Ishida

大腸癌手術の根治性において, 腫瘍から切離断端までの距離は重要な因子の一つである, しかし外科医が手術中測定し記載した腫瘍縁から切離断端までの距離に比し, 切除標本を扱う病理医の記載した切離断端までの距離が著しく短い場合をしばしば経験する. 本研究の目的は, 開腹直後の手術操作の加わっていない状態, 手術操作中の引っ張られた状態, ホルマリン固定後の3種類の状態での腸管の長さを測定対比することであり, 従来これら3種の状態での長さを同時に比較した報告はなかった. 大腸切除を受けた111例の大腸癌患者を対象とした. 盲腸から上部直腸までの腸管は, 開腹直後の長さに比し, 術中引っ張られると平均24-28%伸展し, 切除固定された後には平均24-28%短縮した. 年齢, 性別, 大腸の部位による差はみられなかった. 外科医は腸管が手術操作により24-28%伸展し, 切除固定後24-28%短縮することを念頭に置いて腸管切離線を決定すべきと思われた.

10.3862/jcoloproctology.48.7_635

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A CASE OF TUBERCULOUS ABSCESS OF THE NECK PROMPTLY DIAGNOSED BY POLYMERASE CHAIN REACTION METHOD

The journal of the Japanese Practical Surgeon Society (1993)

Masatoshi Ohta Yutaka Tokuda Yuko Yanagita Soichi Kuge A. Okumura

We experienced a case of abscess of the neck caused by Mycobacterium tuberculosis, which was precisely diagnosed by the polymerase chain reaction (PCR) method. A 67-year-old woman was seen at the hospital because of a swelling in the right anterior region of the neck which was noticed 3 weeks before and then associated with skin redness and hot sensation. On physical examination, along the lateral edge of the right sternocleidomastoid muscle, a fixed and elastic-hard mass measured 6.5×4.5cm was palpated without tenderness. Although needle aspiration of the mass revealed a purulent content, microscopic examination demonstrated no causative microorganisms including mycobacteria and aerobic bacteria. Histology of the mass was necrotizing lymphadenitis without granulation. Since PPD reaction was strongly positive, tuberculosis was highly suspected. The PCR method successfully detected the DNA specific to tubercle bacillus from the neck mass. Subsequently anti-mycobacterial therapy was started without any delay and the mass regressed.

Neck mass

Sternocleidomastoid muscle

10.3919/ringe1963.54.1497

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[Preoperative gastric acid secretion of gastric cancer patients and their prognosis].

PubMed (1990)

Kyoji Ogoshi Kunihiro Iwata Shoko Hara Y Kondoh Toshio Mitomi

This study was performed to evaluate how preoperative gastric acid secretion in gastric cancer patients correlated their prognosis. The results are as follows. 1) The 5-year survival rates of patients with MAO = 0mEq/h, 0mEq/h less than MAO less than or equal to 7.0mEq/h and 7.0mEq/h less than MAO were 29.2%, 73.6% and 88.4%, respectively. There were significant differences among them. 2) The patients with 7.0mEq/h less than MAO had normal cellular immunity and low immunosuppressive glycoproteins in sera. These results suggest that gastric cancer patients who have a potency of normal gastric acid secretion with normal cellular immunity, or who have a potency of normal immunity with normal gastric acid secretion, have a good prognosis.

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Citations (2)

Serum gastrin levels in gastric cancer

Biomedical Research-tokyo (1994)

Makoto Miyaji Kyoji Ogoshi Y Kondoh T Tajima Toshio Mitomi

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[Clinical usefulness of FUT-187 (sepimostat mesilate) on reflux esophagitis and gastritis after gastrectomy].

PubMed (1995)

H Makuuchi K Kanno Toshio Mitomi

The efficacy and safety of the proteolytic enzyme inhibitor FUT-187 were evaluated in postgastrectomy reflux esophagitis and gastric remnant inflammation. FUT-187 was administered orally in a dose of 50 mg four times daily, after meals and bedtime, for periods of 4 to 8 weeks. The subjects consisted of 4 patients with postgastrectomy reflux esophagitis and 9 patients with gastric remnant inflammation. In the endoscopic classification of lesions, postgastrectomy reflux esophagitis was classified as erosive or ulcerative and gastric remnant inflammation as superficial. The general improvement rating, general improvement rating of endoscopic findings, and final global improvement rating were 85% (11/13), 82% (9/11), and 85% (11/13), respectively. Neither adverse reactions nor abnormal laboratory findings due to the test drug were noted. Based on the results of this study, it may be concluded that FUT-187 is an effective drug with a wide margin of safety for postgastrectomy reflux esophagitis and gastric remnant inflammation.

Reflux esophagitis

Esophagitis

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Citations (1)

Use of cultured human epidermal allografts for the treatment of extensive partial thickness scald burn in children.

PubMed (1993)

Jinichi Soeda Sadaki Inokuchi Shintaro Ueno Shozo Yokoyama Masako Kidokoro

In spite of recent progress in burn treatment, the early surgical therapy of partial thickness scald burns in children is still controversial. Early tangential excisions is not easily applicable for these patients because of difficulties in determination of the burn depth and probable physiological derangement after surgery. Hypertrophic scar formation and wound contraction after meshed autografts are other limitations. For these reasons, conservative treatment, not early excision therapy, has been chosen initially for these injuries. We used cultured epidermal allografts for extensive, partial thickness scald burns, during the early post-burn period without escharectomy. Fifty to 100% of the engrafted superficial dermal burns were epithelialized within 7 days. In contrast, untreated identical wounds remained open. Repeated grafting of cultured allografts on unexcised wound granulations of dermal burns also enhanced epithelialization. Long term results showed that hypertrophic scar formation in the mixed superficial and deep dermal burns was reduced when cultured allografts were used. Allografting of the cultured epidermis without surgical excision apparently promoted the rapid regeneration of the partial thickness burns. Procedural complications did not occur. Cultured allografts should be used as an effective and safe biological dressing for partial thickness scald burns in children.

Hypertrophic scars

Skin grafting

Severe burn

Epidermis (zoology)

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Citations (9)

Immunotherapy for Esophageal Cancer

American Journal of Clinical Oncology (1995)

Kyoji Ogoshi Hiroshi Satou Kaichi Isono Toshio Mitomi Mitsuo Endoh

We investigated the effect of multimodal therapy in 187 patients with esophageal cancer. All patients were followed up over a period of 5 years. Among the 187 patients, 174 (93.1%) eligible patients with biopsy-proved esophageal squamous cell carcinoma underwent esophagectomy and were randomly assigned to receive radiotherapy (RT) with or without protein-bound polysaccharide (PSK), or RT plus chemotherapy (CT) with or without PSK. The 5-year survival rates of patients with RT, RT+PSK, RT+CT and RT+CT+PSK were 40.0%, 42.3%, 29.1% and 37.2%, respectively. There was a tendency for longer survival on PSK, but statistical significance was not reached (RT+CT group versus RT+CT+PSK group: log-rank and generalized Wilcoxon tests, P = .1930, P = .1034). However, Cox multivariate regression analysis indicated that postoperative therapy with or without PSK was the most significant prognostic factor for patients receiving RT+CT and for the eligible patients. These results indicate that PSK may have a beneficial effect on esophageal carcinoma when given in combination with CT+RT.

Esophageal disease

10.1097/00000421-199506000-00007

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Citations (59)

Suppressive Effect of the Intraportal Injection of 5-fluorouracil · Uracil · Degradable Starch Microsphere on Experimental Microscopic Liver Metastases of Colon Cancer

The Japanese Journal of Gastroenterological Surgery (1992)

Hitoshi Hanaue Kohshi Kanno Hirotzugu Kubo Seiei Yasuda Tomoo Tajima

Uracil

10.5833/jjgs.25.935

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B.T. PABA Test (Third Report) : A Pancreatic Exocrine Function Test