Hélène Rousseau

Centre Hospitalier Régional et Universitaire de Nancy

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Éric Vicaut

Hôpital Lariboisière

Cédric Baumann

Centre Hospitalier Régional et Universitaire de Nancy

Stéphanie Bourion-Bédès

Université de Versailles Saint-Quentin-en-Yvelines

Gilles Montalescot

Assistance Publique – Hôpitaux de Paris

Laurent Peyrin‐Biroulet

Université de Lorraine

Cyril Tarquinio

Université de Lorraine

Armel Salmon

Ecosystèmes, Biodiversité, Evolution

Johanne Silvain

Pitié-Salpêtrière Hospital

Malika L. Aïnouche

Université de Rennes

Stephen O’Connor

North East London NHS Foundation Trust

Cooperative Institutions

Inserm

263

Assistance Publique – Hôpitaux de Paris

182

Université Paris Cité

133

Centre National de la Recherche Scientifique

122

Université de Lorraine

116

Sorbonne Université

113

Centre Hospitalier Régional et Universitaire de Nancy

111

University of Toronto

Hôpital Lariboisière

University of British Columbia

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Family Medicine Forum Research Proceedings 2013/Compte rendu sur la recherche au Forum en médecine familiale 2013

Canadian Family Physician (2014)

Donna Manca Carolina Aguilar Denise Campbell‐Scherer Kami Kandola Kris Aubrey‐Bassler

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Citations (2)

P2Y12 receptor inhibition and effect of morphine in patients undergoing primary PCI for ST-segment elevation myocardial infarction

Thrombosis and Haemostasis (2016)

Johanne Silvain Robert F. Storey Guillaume Cayla Jean-Baptiste Esteve Jean-Guillaume Dillinger

Summary PRIVATE-ATLANTIC (P2Y12 Receptor Inhibition with VASP Testing using Elisa kit during the ATLANTIC study) is a pre-specified substudy of the randomised, double-blind ATLANTIC trial in patients with ST-segment elevation myocardial infarction, designed to help interpret the main trial results. The primary objective of ATLANTIC was to assess coronary reperfusion prior to percutaneous coronary intervention (PCI) with pre- vs in-hospital ticagrelor 180 mg loading dose (LD). PRIVATE-ATLANTIC assessed platelet inhibition in 37 patients by measurement of vasodilator-associated stimulated phosphoprotein (VASP) platelet reactivity index (PRI) and VerifyNow platelet reactivity units (PRU) before angiogram (T1), immediately after PCI (T2), 1 (T3), and 6 (T4) hours (h) after PCI, and before next study drug administration (T5). The median time difference between the two ticagrelor LD was 41 minutes. Platelet reactivity was unaffected at T1 when measured by VASP-PRI (89.8 vs 93.9% for pre- and in-hospital ticagrelor, respectively; p = 0.18) or PRU (239 vs 241; p = 0.82). Numerical differences were apparent at T2 and maximal at T3. Morphine administration significantly delayed onset of platelet inhibition at T3 (VASP-PRI 78.2 vs 23.4% without morphine; p = 0.0116) and T4 (33.1 vs 11.0%; p = 0.0057). In conclusion, platelet inhibition in ATLANTIC was unaffected by pre-hospital ticagrelor administration at the time of initial angiogram due to the short transfer delay. The maximum difference in platelet inhibition was detected 1 h after PCI (T3). Morphine administration was associated with delayed onset of action of ticagrelor and appeared more important than timing of ticagrelor administration.

Loading dose

10.1160/th15-12-0944

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Citations (100)

Dose de-escalation to adalimumab 40 mg every three weeks in patients with inflammatory bowel disease—A multicenter, retrospective, observational study

Digestive and Liver Disease (2018)

Lieven Pouillon Anne Lamoureux Guillaume Pineton de Chambrun Lucine Vuitton Benjamin Pariente

10.1016/j.dld.2018.10.022

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Citations (16)

Impact of presentation and transfer delays on complete ST-segment resolution before primary percutaneous coronary intervention: insights from the ATLANTIC trial

EuroIntervention (2017)

Enrico Fabris Arnoud W.J. van ’t Hof Christian W. Hamm Frédéric Lapostolle Jens Flensted Lassen

Aims:The aim of this study was to identify predictors of complete ST-segment resolution (STR) pre-primary percutaneous coronary intervention (PCI) in patients enrolled in the ATLANTIC trial.Methods and results: ECGs recorded at the time of inclusion (pre-hospital [pre-H]-ECG) and in the catheterisation laboratory before angiography (pre-PCI-ECG) were analysed by an independent core laboratory.Complete STR was defined as ≥70%.Complete STR occurred pre-PCI in 12.8% (204/1,598) of patients and predicted lower 30-day composite MACCE (OR=0.10,95% CI: 0.002-0.57,p=0.001) and total mortality (OR=0.16,95% CI: 0.004-0.95,p=0.035).Independent predictors of complete STR included the time from index event to pre-H-ECG (OR=0.94,95% CI: 0.89-1.00,p=0.035), use of heparins before pre-PCI-ECG (OR=1.75,95% CI: 1.25-2.45,p=0.001) and time from pre-H-ECG to pre-PCI-ECG (OR=1.09,95% CI: 1.03-1.16,p=0.005).In the pre-H ticagrelor group, patients with complete STR had a significantly longer delay between pre-H-ECG and pre-PCI-ECG compared to patients without complete STR (median 53 [44-73] vs. 49 [38.5-61]mins, p=0.001); however, this was not observed in the control group (in-hospital ticagrelor) (50 [40-67] vs. 49 [39-61] mins, p=0.258).Conclusions: Short patient delay, early administration of anticoagulant and ticagrelor if a long transfer delay is expected may help to achieve reperfusion prior to PCI.Pre-H treatment may be beneficial in patients with longer transfer delays, allowing the drug to become biologically active.ClinicalTrials.gov

10.4244/eij-d-16-00965

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Citations (18)

Suivi prospectif des fractures du massif trochantérien ostéosynthèsées par un clou centromédullaire à recul limité et contrôlé

Revue de Chirurgie Orthopédique et Traumatologique (2017)

Manuela Barla François Egrise Hélène Rousseau B. Gavanier Bogdan Zaharia

10.1016/j.rcot.2017.09.206

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Stress and associated factors among French university students under the COVID-19 lockdown: The results of the PIMS-CoV 19 study

Journal of Affective Disorders (2021)

Stéphanie Bourion-Bédès Cyril Tarquinio Martine Batt Pascale Tarquinio Romain Lebreuilly

Postponement

Perceived Stress Scale

Protective factor

10.1016/j.jad.2021.01.041

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Citations (99)

Evolution des génomes polyploïdes et innovations fonctionnelles : contexte phylogénétique et origine du DMSP chez les spartines

Hélène Rousseau

Le Dimethylsulfoniopropionate (DMSP) est une molecule a fort impact ecologique couramment produite par le phytoplancton marin, mais tres rarement chez les plantes a fleurs: seulement chez quelques genres (dont Spartina chez les Poacees). Bien que les etapes enzymatiques impliquees dans la voie de biosynthese du DMSP soient connues chez les spartines, son origine ainsi que les genes impliques restent encore a decouvrir chez les plantes. Cette etude s’est fixee pour objectif de contribuer a elucider les mecanismes a l’origine de cette fonction chez les spartines. Cette question a ete apprehendee a travers differentes approches : biochimique, metabolomique, transcriptomique, genomique comparative et phylogenetique. Les resultats ont montre que la capacite a synthetiser le DMSP a une origine unique au sein du genre Spartina et se serait mise en place il y a 3-10 millions d’annees. Cette capacite est intervenue chez l’ancetre d’un des deux principaux clades (hexaploide) de spartines, puis a ete heritee chez toutes les especes derivant de ce clade (hexaploides a dodecaploides). Les especes de l’autre clade (tetraploide) et leurs descendants (quel que soit leur niveau de ploidie) n’accumulent pas de DMSP. En utilisant les genomes sequences des especes de Poacees ainsi que les ressources genomiques et transcriptomiques disponibles chez les spartines, les genes candidats intervenant dans les 4 etapes de la voie de biosynthese proposee dans la litterature ont ete explores. L’identification des genes intervenant dans les deux etapes intermediaires, supposees specifiques de la capacite de synthese du DMSP represente un veritable defi dans la mesure ou seules des activites enzymatiques putatives ont ete proposees a ce jour (sans connaissance des enzymes specifiques ni de leur sequence proteique). Nous avons pu identifier une serie de genes candidats pour chacune des deux fonctions concernees (decarboxylase et amine oxydase), comparer leur niveau de transcription entre les especes DMSP+ et DMSP-, et predire leur localisation cellulaire. De plus, des analyses d’activites enzymatiques ont permis de formuler de nouvelles hypotheses et pistes de recherches sur l’emergence de cette nouvelle voie de biosynthese chez les spartines.

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The Impact of COVID-19 on Patients with IBD in a Prospective European Cohort Study

Journal of Crohn s and Colitis (2022)

Aurélien Amiot Jean‐François Rahier Filip Baert Stéphane Nahon Ailsa Hart

Abstract Background and Aims There are concerns regarding the potential impact of the COVID-19 outbreak on patients with inflammatory bowel disease [IBD]. We report on the impact of the COVID-19 outbreak in a European prospective cohort study of patients with IBD Patients and Methods We prospectively collected data from 5457 patients with IBD nested in the ongoing I-CARE project and still followed up in April 2020, with monthly online monitoring of clinical activity, treatment, imaging and endoscopy. Investigators were also contacted to report incidental cases. Results In total, 233 [4.3%] reported COVID-19 and 12 [0.2%] severe COVID-19, with no COVID-19 deaths. The risk of COVID-19 in patients with IBD was not increased compared to the general population (standardized incidence ratio [SIR]: 1.18, 95% confidence interval [CI] [1.03–1.34], p = 0.009), as well as the risk of severe COVID-19 (SIR: 0.69, 95% CI [0.35–1.20], p = 0.93). We did not observe any negative impact of the different IBD-related medication on the risk of either COVID-19 or severe COVID-19. In 2020, the COVID-19 outbreak resulted in a drastic decrease in endoscopic and imaging procedures from March to May 2020 compared to 2018 and 2019. No impacts on clinical IBD disease activity as well as ongoing treatment were noted. Conclusion No increases in either COVID-19 or severe COVID-19 incidences were observed in patients with IBD. There was no impact of COVID-19 on IBD-related medication and clinical activity. Access to endoscopy and imaging was restricted during the first months of the first COVID-19 outbreak.

10.1093/ecco-jcc/jjac091

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Citations (11)

Evolution of DMSP (dimethylsulfoniopropionate) biosynthesis pathway: Origin and phylogenetic distribution in polyploid Spartina (Poaceae, Chloridoideae)

Molecular Phylogenetics and Evolution (2017)

Hélène Rousseau Mathieu Rousseau‐Gueutin Xavier Dauvergne Julien Boutte Gaëlle Simon

Spartina

Dimethylsulfoniopropionate

Spartina alterniflora

Lineage (genetic)

Polyploid

10.1016/j.ympev.2017.07.003

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Citations (11)

Effect of the COVID-19 Outbreak and Lockdown on Mental Health Among Post-Secondary Students in the Grand Est Region of France: Results of the PIMS-Cov19 Study

Research Square (Research Square) (2021)

Cédric Baumann Hélène Rousseau Cyril Tarquinio Martine Batt Pascale Tarquinio

Abstract Background. The COVID-19 epidemic has sent billions of students into lockdown in the world. This study sought to assess the prevalence of impaired self-perceived mental health and identify associated factors among French post-secondary students during the lockdown. Methods. A cross-sectional study was conducted among French students living in the Grand Est area in France from May 7 to 17, 2020 during the first lockdown. An online survey was used to collect sociodemographic data, learning and teaching conditions, living conditions, and exposure to COVID-19, and self-perceived mental health was assessed with mental composite score (MCS) of the SF-12. Results. Overall, 4,018 were analyzed. Most participants were female (70.7%), and the mean age was 21.7 years (SD 4.0). The mean MCS score was 44.5 (SD 17.3). Impaired mental health, defined by a MCS<1rst Quartile, was mainly associated with female sex; decreased time for learning; not having access to the outside with a garden, a terrace or a balcony; difficulties with the living situation and having someone in the home affected by the SARS-COV2 requiring hospitalization or not. Conclusion. This study showed that living conditions during lockdown had a clear impact on the mental health of French post-secondary students. There is a need to improve prevention and to access distance education as well as an urgent need for measures to develop healthy coping strategies for students. This is a major challenge to prevent these disorders from developing into true psychiatric illnesses.

Quartile

Cross-sectional study

10.21203/rs.3.rs-534261/v1

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Citations (1)