Claudia Niegel

University of Regensburg

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Frank‐Michael Matysik

University of Regensburg

Jürgen Mattusch

Helmholtz Centre for Environmental Research

Marco Grundmann

University of Regensburg

Bruce McCord

Florida International University

Simon A. Pfeiffer

Leipzig University

Uriel Arroyo‐Abad

Helmholtz Centre for Environmental Research

Olivier L. Collin

Ohio University

Glen P. Jackson

West Virginia University

Kate E. DeRhodes

Ohio University

Cooperative Institutions

University of Regensburg

Ohio University

Leipzig University

Helmholtz Centre for Environmental Research

Deutsches Biomasseforschungszentrum

Deutsches Elektronen-Synchrotron DESY

University of Pittsburgh

Environmental Protection Agency

Lublin University of Technology

Lawrence Livermore National Laboratory

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Fast separations by capillary electrophoresis hyphenated to electrospray ionization time-of-flight mass spectrometry as a tool for arsenic speciation analysis

The Analyst (2012)

Claudia Niegel Simon A. Pfeiffer Marco Grundmann Uriel Arroyo‐Abad Jürgen Mattusch

Fast capillary electrophoresis (CE) hyphenated to time-of-flight mass spectrometry (TOF-MS) of four organoarsenic species (glycerol oxoarsenosugar, sulfate oxoarsenosugar, arsenobetaine, arsenocholine) are presented using short length CE capillaries under high electric field strengths of up to 1.3 kV cm−1 with small inner diameter (ID). The separation of arsenosugars by CE is demonstrated for the first time. An aqueous formic acid solution was employed as the background electrolyte (BGE) for the separation. Various acid concentrations were evaluated for their influence on migration times, separation efficiency as well as with regard to controlling the charge of the arsenic species. A 0.1 M formic acid/ammonium formate buffer (pH 2.8) proved to be suitable for the separation of the four species. A non-aqueous BGE was tested as an alternative buffer system for fast speciation analysis. Separation of arsenobetaine and arsenocholine could even be achieved within 10 s by pressure-assisted CE. Application of the optimized method for the analysis of extracts of a seagrass and a Wakame algae sample as well as the brown algae homogenate reference material IAEA-140/TM revealed a clear signal for the glycerol arsenosugar.

Genetic algorithm

Capillary electrophoresis–mass spectrometry

10.1039/c2an15944a

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Fast Gas Chromatography of Explosive Compounds Using a Pulsed‐Discharge Electron Capture Detector^*

Journal of Forensic Sciences (2006)

Olivier L. Collin Claudia Niegel Kate E. DeRhodes Bruce McCord Glen P. Jackson

ABSTRACT: The detection of a mixture of nine explosive compounds, including nitrate esters, nitroaromatics, and a nitramine in less than 140 sec is described. The new method employs a commercially available pulsed‐discharge electron capture detector (PDECD) coupled with a microbore capillary gas chromatography (GC) column in a standard GC oven to achieve on‐column detection limits between 5 and 72 fg for the nine explosives studied. The PDECD has the benefit that it uses a pulsed plasma to generate the standing electron current instead of a radioactive source. The fast separation time limits on‐column degradation of the thermally labile compounds and decreases the peak widths, which results in larger peak intensities and a concomitant improvement in detection limits. The combination of short analysis time and low detection limits make this method a potential candidate for screening large numbers of samples that have been prepared using techniques such as liquid–liquid extraction or solid‐phase microextraction.

Electron capture detector

Electron capture

Explosive detection

10.1111/j.1556-4029.2006.00171.x

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Analytical methods for the determination of arsenosugars—A review of recent trends and developments

Analytica Chimica Acta (2009)

Claudia Niegel Frank‐Michael Matysik

Analytical procedures

Sample Preparation

10.1016/j.aca.2009.10.041

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Citations (64)