Yaeko Murata

Tohoku University

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[Immunopathological analysis of T and non-T cell involvement in corneal inflammation caused by HSV type-1 infection].

PubMed (1989)

T Kimura Yaeko Murata Toshiyuki Yamaguchi Ko Okumura

In herpetic keratitis, the role of T cell subsets is not clearly understood although the involvement of cell-mediated immunity has been reported. The purpose of this paper is to analyse T cell-mediated immunopathological conditions and the role of non-T cell lineage in herpetic stromal keratitis employing nude (nu/nu) and Balb/c mice. All mice were divided into three groups. Group 1: Herpes simplex virus type 1 (HSV-1)-inoculated nu/nu mice. Group 2: HSV-1-inoculated nu/nu mice with interleukin-2 (IL-2). Group 3: HSV-1-inoculated Balb/c mice. The conditions of the disease were compared in those three groups clinically and by using histological and immunopathological staining. Following antibodies were employed: anti-Asialo GMI (natural killer). anti-Thy 1 (pan-T). anti-L3T4 (helper/inducer), anti-Lyt 2 (suppressor/killer), anti-Mac 3 (macrophage), anti-Mice Immunoglobulins (monocyte. B.). Corneal lesions showed a reduced inflammatory tendency in nu/nu mice. Topical application of IL-2 in nu/nu mice induced moderate stromal inflammation compared with nu/nu mice. However, the severity of these was less than in Balb/c. Many natural killer cells (NK) were found in nu/nu mice but few in Balb/c mice. These results confirm the involvement of T-cell mediated immunity in stromal inflammation and indicate that NK cell may have an important role in suppressed T-cell immunity in nu/nu mice but are not involved in stromal inflammation.

Corneal inflammation

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Citations (1)

Immunopathological Analysis of Corneal Inflammation Caused by HSV Type 1 Infection

Cornea (1987)

T Kimura Yaeko Murata Tsuyoshi Yamaguchi A Kanai Ko Okumura

Kimura, T.; Murata, Y.; Yamaguchi, T.; Kanai, A.; Okumura, K.; Nakajima, A. Author Information

Corneal inflammation

10.1097/00003226-198706020-00028

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Citations (1)

Effect of allopurinol on cardiovascular incidence among hypertensive nephropathy patients: the Gonryo study

Clinical and Experimental Nephrology (2012)

Hiroyuki Terawaki Masaaki Nakayama Emiko Miyazawa Yaeko Murata Keisuke Nakayama

Allopurinol

Nephrology

Xanthine oxidase inhibitor

Stroke

10.1007/s10157-012-0742-z

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Citations (37)

Immunodeficiency and IL-6 production by peripheral blood monocytes in multicentric Castleman's disease

British Journal of Haematology (1994)

T Ishiyama Shinji Nakamura Y Akimoto Michiaki Koike Shigeru Tomoyasu

To study the pathogenesis of multicentric Castleman's disease (MCD), IL-6 producing cells and immune function were investigated in four MCD patients. The expression of IL-6 mRNA in one MCD lymph node was analysed by in situ hybridization. IL-6 mRNA expressing cells were scattered in the interfollicular areas and did not resemble plasma cells. Spontaneous IL-6 production was detected in the culture supernatants of peripheral blood mononuclear cells (PBMNC) from four patients. The IL-6 producing cells among the PBMNC were found to be monocytes by both in situ hybridization and immunohistochemistry. We evaluated immune function in four MCD patients. These studies show: (1) a negative PPD skin test in 3/4 patients, (2) decreased IL-2 production in 3/4 patients, (3) decreased T cell colony formation in 3/4 patients, (4) decreased NK activity and NK cell number in 2/4 patients, (5) increased soluble IL-2 receptor in 4/4 patients, and (6) decreased CD4/CD8 ratio in 3/4 patients. These results show that MCD resembles, in several ways, acquired immunodeficiency syndrome (AIDS).

Castleman disease

10.1111/j.1365-2141.1994.tb04777.x

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Citations (49)

Erratum to: Effect of allopurinol on cardiovascular incidence among hypertensive nephropathy patients: the Gonryo study

Clinical and Experimental Nephrology (2013)

Hiroyuki Terawaki Masaaki Nakayama Emiko Miyazawa Yaeko Murata Keisuke Nakayama

Allopurinol

Nephrology

10.1007/s10157-012-0769-1

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Citations (1)

HTLV-1 associated dermatomyositis.

Nihon Naika Gakkai Zasshi (2002)

Hideyuki Murakoshi Naoki Sano Yuki Meguro Kuniaki Matsui Yaeko Murata

症例は66歳,女性でHTLV-1キャリア.嚥下障害,歩行障害が出現し,ヘリオトロープ疹と近位筋の対称性萎縮を認めた.血中筋原性酵素の高値,筋電図,大腿筋生検所見より皮膚筋炎と診断.プレドニゾロン投与により筋原性酵素は正常化し,自他覚症状と筋組織所見の改善が認められた.本例では様々な自己抗体の出現を伴っており,ウイルス感染と自己免疫疾患との関連が示唆された.

10.2169/naika.91.2183

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Citations (0)

Fast oscillations of the electro-oculogram in a series of normal subjects.

PubMed (1995)

Hironori Nakao Nobuhiro Miki Masaharu Nagata Yuji C. Sasaki Atsushi Yamasaki

Using a newly devised automated electro-oculograph, Nidek EOG-2, the fast oscillations (FOs) of the electro-oculogram were recorded in the 120 eyes of 60 normal subjects. We evaluated the normal means and variability of FO parameters, namely the "Rf" value, which is the average ratio in percentage of the maximum amplitude in the dark period (AD)/the minimum amplitude in the light period (AL), and the "df" value, which is the average difference between AD and AL during the FO measurement. No correlation with age was noted in the "Rf" value, although the lowest mean value of the "df" was detected in the twenties. Regarding sex, the mean levels of the "Rf" and "df" for female subjects were statistically higher than those for male subjects in the younger and global age groups. Some hormonal factor which can stimulate the metabolic activity of the retinal pigment epithelium might have caused this sexual difference.

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Normal values

Electrooculography

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Citations (5)

Tc-99m DTPA renography in patients with collagen disease.

Clinical Nuclear Medicine (2001)

Mikio Tezuka Yaeko Murata Ryo Ishida Yoshiaki Sawada H. Shibuya

This study evaluated the use of Tc-99m DTPA renography in patients with collagen disease.Tc-99m DTPA renal scintigraphy was performed in 28 patients with clinically diagnosed collagen disease. Twenty-two other patients who underwent renal scintigraphy and were subsequently shown to have no kidney abnormalities served as the control group.One quarter of the patients with collagen disease had abnormal findings of renography, despite the absence of abnormal laboratory data. Renograms were 100% sensitive for the detection of renal disease in patients with collagen disease, and their specificity was 53% when serum blood urea nitrogen, serum creatinine concentration, and proteinuria were the only measures of renal impairment considered. The glomerular filtration rate was not significantly different between the groups, but the bilateral time to peak was significantly greater in the patients with collagen disease. Hydronephrosis was present in 7% of patients with collagen disease.Renography is useful for detecting early changes of renal involvement when the clinical state of collagen disease is evaluated.

Collagen disease

Blood urea nitrogen

10.1097/00003072-200103000-00001

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Citations (1)

A case of hypercalcemia in association with acute renal failure due to rhabdomyolysis.

Nihon Toseki Igakkai Zasshi (2003)

Yaeko Murata Jun Soma Takehiro Suzuki Masahiro Miyata Keisuke Nakayama

症例は26歳男性. 1998年11月, 海外でのハーフマラソンに出場し熱中症を生じて, 横紋筋融解症による急性腎不全を合併した. 現地にて2回の血液透析施行後帰国. 空港近くの高次救命救急センターに収容され血液透析を受け, 2日後当院へ転入院した. 当院入院時, 依然乏尿状態にあり, BUN 104mg/dL, Cr 8.1mg/dL, CPK 2,128IU/L, 血中ミオグロビン11,700ng/mLであったためさらに3回の血液濾過透析を行った. その後利尿期 (回復期) に至ったが, 高カルシウム血症 (血清Ca 16.2mg/dL) が出現した. 高カルシウム血症に対し, prednisolone (40mg/日静脈内投与), elcatonin (40単位筋肉注射) と生理食塩水の補液の投与を行ったところ10日後には血清カルシウム値 (血清Ca 10.1mg/dL) は正常化した. これまでの本邦での報告例は少ないが, 横紋筋融解症による急性腎不全の利尿期に時として高カルシウム血症を生じることがあり, 十分な注意が必要である.

Prednisolone

10.4009/jsdt.36.67

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Citations (0)

Central diabetes insipidus caused by neurosarcoidosis.

Nihon Naika Gakkai Zasshi (2001)

Yaeko Murata Kuniaki Matsui Naoki Sano Yuki Meguro

症例は24歳,女性.多飲,多尿の精査のため紹介され,飲水制限-ピトレッシン試験で中枢性尿崩症と診断した.虹彩毛様体炎,両側肺門部リンパ節腫脹がみられ,ツ反陰性で臨床的に定型的なサルコイドーシスを示した.軽度の髄液中リンパ球増加のほか脳MRI T1強調画像で下垂体茎の軽度肥厚とgadolinium (Gd)による信号増強所見があり,神経サルコイドーシスと考えられた.プレドニゾロン投与後,眼症状は改善し,肺門リンパ節腫脹は消失したが,中枢性尿崩症は持続した.神経サルコイドーシスを原因とする中枢性尿崩症はまれであり文献的考察を加えて報告する.

Neurosarcoidosis

10.2169/naika.90.690

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Citations (0)