Timur Issagulov

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Berik Khairullin

Institute for Biological Sciences

Markhabat Kassenov

Kazakh Scientific Research Veterinary Institute

Marina Stukova

Research Institute of Influenza

Gulbanu Sarsenbayeva

Ministry of Education and Science of the Republic of Kazakhstan

Yevgeniy Volgin

Institute for Biological Sciences

Nikolay Bogdanov

University of Zurich

Ruslan Abitay

Timur Davlyatshin

Weatherford College

Abylay Sansyzbay

Kazakh National Agrarian Research University

Zhanna Buzitskaya

Research Institute of Influenza

Cooperative Institutions

Institute for Biological Sciences

Ministry of Education and Science of the Republic of Kazakhstan

Institute of Biomedical Problems

Agrobioinstitute

Research Institute of Influenza

Ministry of Health of the Russian Federation

Kazakh Scientific Research Veterinary Institute

Kazakh Institute of Oncology and Radiology

Kazakh National Agrarian Research University

University of Zurich

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

A novel preservative‐free seasonal influenza vaccine safety and immune response study in the frame of preclinical research

Journal of Medical Virology (2017)

Gulbanu Sarsenbayeva Yevgeniy Volgin Markhabat Kassenov Timur Issagulov Nikolay Bogdanov

The paper describes the results of preclinical testing of the preparation "Vaccine allantoic split-virus inactivated against seasonal influenza." Acute toxicity and local irritating effect, anaphylactic reactions to different antigens (vaccine and ovalbumin), delayed-type hypersensitivity to ram erythrocytes, humoral immune response in hemaggtination reaction, immunogenic activity was studied in laboratory animals of various species (mice, rats, guinea pigs). Comparative analysis of the results from testing immunogenic activity of the preparation under study and the commercial influenza vaccines was performed. The preclinical testing has demonstrated safety and immune response of the seasonal split influenza vaccine, so it may be recommended for clinical study on limited contingent of volunteers.

Seasonal influenza

10.1002/jmv.24771

Cite

Citations (5)

influenza monitoring among birds in Kostanaiskaya Oblast, Republic of Kazakhstan

Agriculture and Biology Journal of North America (2010)

Markhabat Kassenov Berik Khairullin Zhailaubay Kydyrbayev Seidigapbar M. Mamadaliyev V. L. Zaitsev

Epizootological monitoring of avian influenza (AI) occurrence in Kostanaiskaya oblast of Kazakhstan was conducted.The staff of the laboratories of the Research Institute for Biological Safety Problems carried out the research in virus isolation from the materials sampled from wild and domestic birds in Kostanaiskaya oblast with use of double blind passage in chicken embryos (CE), hemagglutination test, polymerase chain reaction and electron microscopy.The laboratory studies resulted in detection of an AI virus antigen H5N1 in samples from gulls, starlings and from a mallard.

10.5251/abjna.2010.1.5.737.739

Cite

Citations (1)

Safety and immunogenicity of trivalent inactivated influenza vaccine in adults 60 years of age and older: a phase II, a randomized, comparative trial in Kazakhstan

Human Vaccines & Immunotherapeutics (2020)

Gulbanu Sarsenbayeva Timur Issagulov Markhabat Kassenov Ruslan Abitay Mukhit Orynbayev

Background The study was aimed at comparative evaluation of seasonal influenza vaccine RIBSP versus commercial vaccine VAXIGRIP® for immunogenicity and safety in the course of clinical trial phase II on healthy subjects up to 60 years.Methods The trial involved 150 subjects in randomized 2:1 groups that received either RIBSP vaccine or comparator vaccine VAXIGRIP®. One dose (0.5 ml) of either vaccine contained 15 µg of hemagglutinin of each influenza virus strain recommended by WHO for the Northern hemisphere in 2016–2017 flu season. The observation period lasted 21 days. The trial was registered at ClinicalTrials.gov identifier NCT 03016143.Results Assessment of immunogenic activity of the vaccine under study showed that in 21 days the portion of participants with 4-fold seroconversions was 80.0% to А/H1N1; 65.0% to А/H3N2 and 64.0% to B virus. Antibody titer increase factor in the group of subjects that received RIBSP vaccine was 13.4 for А/H1N1; 5.2 for А/H3N2 and 5.2 for B virus. The subjects that received RIBSP vaccine demonstrated 88% seroprotection rate against А/H1N1; 75% against А/H3N2 and 61% against B virus. In the course of evaluating the vaccine safety, no serious adverse events were recorded. All changes of laboratory data were slight and single in most cases. All recorded local reactions have been light in character and these have been predicted reactions observed at vaccination against influenza.Conclusion Comparison vaccines RIBSP and VAXIGRIP®, showed similar immunogenic activity. The RIBSP vaccine is safe and immunogenic for the elderly and conforms to international criteria in CPMP/BWP/214/96.

Trivalent influenza vaccine

Inactivated vaccine

10.1080/21645515.2019.1705691

Cite

Citations (3)

Safety and immunogenicity of the novel seasonal preservative‐ and adjuvant‐free influenza vaccine: Blind, randomized, and placebo‐controlled trial

Journal of Medical Virology (2017)

Gulbanu Sarsenbayeva Yevgeniy Volgin Markhabat Kassenov Timur Issagulov Nikolay Bogdanov

The producers of influenza vaccines are not capable today to meet the global demand for an influenza vaccine in case of pandemic, so the World Health Organization recommends to develop the own influenza vaccine production in each country. A domestic preservative- and adjuvant-free trivalent split vaccine against seasonal influenza was developed at the Research Institute for Biological Safety Problems. The paper presents the results of assessing safety and immunogenicity of the influenza split vaccine after single immunization of healthy volunteers aged 18-50 years in the course of Phase I Clinical Trials. This study was randomized, blind, and placebo-controlled. The volunteers were intramuscularly vaccinated with a dose of split vaccine or placebo. The study has shown that all local and systemic reactions had low degree of manifestation and short-term character, so there was no need in medication. Serious side effects were not observed. On day 21 post vaccination the portion of vaccinated persons with fourfold seroconversions to influenza А/H1N1pdm09 virus was 100.0%, to influenza А/H3N2 virus-95.5%, to influenza B virus-81.8%, and in placebo group this index was 0%. Seroprotection rates against influenza А/H1N1pdm09, А/H3N2 and B viruses were 95.5, 86.3, and 72.7%, respectively. Geometric mean titers (GMT) of antibodies by day 21 post vaccination reached 175.7 for influenza А/H1N1pdm09 virus, 64.2 for influenza А/H3N2 virus, and 37.6 for influenza B virus; in placebo group GMT growth was not observed. So, the seasonal influenza split vaccine is well tolerated and fits all immunogenicity criteria for human influenza vaccines.

Seasonal influenza

10.1002/jmv.24922

Cite

Citations (7)

Immunogenicity and safety of a novel seasonal influenza preservative-free vaccine manufactured in Kazakhstan: Results of a randomized, comparative, phase II clinical trial in adults

Human Vaccines & Immunotherapeutics (2017)

Gulbanu Sarsenbayeva Yevgeniy Volgin Markhabat Kassenov Timur Issagulov Nikolay Bogdanov

The study was aimed at comparative evaluation of seasonal influenza vaccine RIBSP versus commercial vaccine VAXIGRIP® for immunogenicity and safety in the course of clinical trial phase II on healthy volunteers aged 18-60 years.The trial involved 150 subjects in randomized 2:1 groups that received either RIBSP vaccine or comparator vaccine VAXIGRIP®. One dose (0.5 ml) of either vaccine contained 15 μg of hemagglutinin of each influenza virus strain recommended by WHO for the Northern hemisphere in 2016-2017 flu season. The observation period lasted 21 day. The trial was registered at ClinicalTrials.gov identifier NCT 03016143.Assessment of immunogenic activity of the vaccine under study showed that in 21 day the portion of participants with 4-fold seroconversions was 87.0% to A/H1N1; 63.0% to A/H3N2 and 59.0% to B virus. Antibody titer increase factor in the group of subjects that received RIBSP vaccine was 23.3 for A/H1N1; 4.4 for A/H3N2 and 4.5 for B virus. The volunteers that received RIBSP vaccine demonstrated 95% seroprotection level against A/H1N1; 84% against A/H3N2 and 80% against B virus. RIBSP vaccine met the CHMP criteria of the Committee for Medicinal Products for Human Use (CPMP/BWP/214/96). In the course of evaluating the vaccine safety no serious undesirable effects were recorded. All changes of laboratory data were slight and single in most cases. All recorded local reactions have been light in character and these have been predicted reactions observed at vaccination against influenza.Comparison of the allantoic inactivated split vaccine obtained in vaccines RIBSP and VAXIGRIP®, showed similar immunogenic activity. Both vaccines were safe for the study participants.

Seasonal influenza

Trivalent influenza vaccine

Seroconversion

10.1080/21645515.2017.1387345

Cite

Citations (4)