Maria Saggese

University of Bari Aldo Moro

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Co-Authors

Maria D’Amato

Ospedale Monaldi

Gennaro D’Amato

Fatebenefratelli Hospital

Gennaro Liccardi

University of Rome Tor Vergata

María Julieta Russo

Azienda Unità Sanitaria Locale Della Romagna

María Julieta Russo

Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia

Gennaro Liccardi

University of Rome Tor Vergata

Maria Donatella Gentili

Deutsches Archäologisches Institut, Abteilung Rom

G. Mistrello

Lofarma (Italy)

Antonella Visone

Vita-Salute San Raffaele University

P. Falagiani

Lofarma (Italy)

Cooperative Institutions

University of Verona

Istituti di Ricovero e Cura a Carattere Scientifico

University of Antwerp

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Ospedale Sacro Cuore Don Calabria

University of Milan

Fatebenefratelli Hospital

University of Campania "Luigi Vanvitelli"

University of Turin

University of Naples Federico II

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Measurement of serum levels of eosinophil cationic protein to monitor patients with seasonal respiratory allergy induced by Parietaria pollen (treated and untreated with specific immunotherapy)

Allergy (1996)

Gennaro D’Amato Gennaro Liccardi María Julieta Russo Maria Saggese Maria D’Amato

This trial studied the behavior of a marker of eosinophilic inflammation, eosinophil cationic protein (ECP), in the peripheral blood of two groups of subjects with seasonal allergic respiratory symptoms (rhinitis and mild bronchial asthma) induced by pollen allergens of Parietaria, judaica ( P.j .) (one group treated and another untreated with specific immunotherapy [SIT]), to determine what contribution these serial measurements might provide, in comparison with various other tools now available for pollinosis monitoring. In a previously randomized order, we selected 25 patients with monosensitization to P.j . pollen allergens; among them, 12 had started SIT with a P.j . extract in autumn 1993. As a control group, 13 patients were untreated. All patients were studied with various tests at four different times: time I ‐ November 1993; time II ‐ February 1994; time III ‐ end of May 1994; and time IV ‐ September 1994. Blood samples for determination of serum ECP were collected at each time. Methacholine challenge tests were performed at times I and III. A pollen count was also carried out. A statistically significant difference (P<0.05) was observed in mean ECP levels at times I and 111 in SIT treated and untreated patients. The interaction between groups and time was not significant. No statistically significant difference was found between PD 20 FEV 1 values at times I and III in either group. After 1 year of treatment, we did not find any effect of SIT on bronchial hyperresponsiveness or on ECP serum values.

Methacholine

Bronchial hyperresponsiveness

10.1111/j.1398-9995.1996.tb04600.x

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Citations (22)

Comparison Between Outdoor and Indoor Airborne Allergenic Activity

Annals of Allergy Asthma & Immunology (1996)

Gennaro D’Amato María Julieta Russo Gennaro Liccardi Maria Saggese Maria Donatella Gentili

Urticaceae

Hay fever

Airborne allergen

10.1016/s1081-1206(10)63501-6

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Citations (57)

Parietaria Pollinosis: Clinical and Epidemiological Aspects

Allergy and Asthma Proceedings (1996)

Gennaro Liccardi Antonella Visone María Julieta Russo Maria Saggese Maria D’Amato

The aim of our study was the evaluation of clinical and epidemiological aspects of P pollen allergy, which is a very frequent cause of respiratory allergy in the Mediterranean area, in a homogeneous group of 442 monosensitive subjects (235 females and 207 males, mean age about 30 years) living in Naples. All patients underwent the following diagnostic procedures: anamnestic evaluation with an internal questionnaire, physical examination, SPT with commercially available allergenic extracts (DHS-Bayropharm Milan Italy); sNPT, NsBPT, and serum specific IgE determinations were also carried out in three groups of 50 different subjects. The results of our study show a highly relevant intensity of SPT positivity (4+ and 3+ in about 95% of patients). The age of onset of clinical symptoms ranged between 20-25 years, and the majority of P monosensitized patients were born in the spring months, with an early exposure to P allergens. Rhinoconjunctivitis and bronchial asthma, alone or association, represent the most common clinical manifestation of this allergy. The season in which patients experience clinical symptoms is prevalently spring (75, 12%). However, many people show a multiseasonal pattern (18, 55%). The frequency of SPT positivity to P allergens is increasing in the last 15 years, probably due to increased urban air pollution. In conclusion, the results of this study demonstrate the high frequency and severity of this pollinosis and seem to confirm some epidemiological aspects connected with other allergenic pollens (birth during the seasonal period of pollination and association with a high urban air pollution).

10.2500/108854196778662381

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Citations (16)

Bruen chains in PG(3,pk), k⩾2

Discrete Mathematics (2000)

Olof Heden Maria Saggese

Chain (unit)

10.1016/s0012-365x(99)00308-8

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Citations (2)

Evaluation of serum specific IgE and skin responsiveness to allergenic extracts of Oleaceae pollens (Olea europaea, Fraxinus excelsior and Ligustrum vulgare) "in patients with respiratory allergy.

PubMed (1995)

Gennaro Liccardi María Julieta Russo Maria Saggese Maria D’Amato Maria D’Amato

In the last few years an increasing interest for Olea europaea (O.e.) pollen has been developed in many countries. Several authors have studied the aerobiological, allergenic, epidemiological and clinical features of this pollinosis. The aim of our study was to evaluate cutaenous and serological responses to other oleaceae pollens allergens (Ligustrum vulgare (L.v.) and Fraxinus excelsior (F.e.) in patients with skin positivity to Olea europaea pollen extract. Twenty-three atopic rhinitis and/or asthmatic patients living in Naples area and with immediate positive skin reaction only to O.e. pollen extract were examined. Patients were tested by skin prick test (SPT) for O.e., F.e. and L.v. with glycerinated allergenic extracts. Serum enzyme immunoassay for the same allergens was also performed. We found a statistically significant correlation between the results of SPT and of specific IgE assay for Oleaceae pollens as well as between the results of the in vivo vs in vitro tests. We suggests the utility, in patients with O.e. pollinosis who travel in Northern europe, to plan SPT and/or specific IgE determinations also with F.e. and L.v. allergenic extracts for the possibility of developing a nasal and/or bronchial symptomatology after the inhalation of these pollen grains.

Oleaceae

Olea

Respiratory allergy

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Citations (10)

Clinical significance of allergic sensitization toOlea europaea L. pollen in Naples area, Italy

Aerobiologia (1994)

Gennaro Liccardi María Julieta Russo Maria Saggese Gaetano Lobefalo Paolo Noschese

Aeroallergen

10.1007/bf02066748

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Citations (10)

Theophylline and syncope

International Journal of Cardiology (2016)

Roberto La Rocca Fulvia Campedel Valeria Materia Maria Saggese Salvatore Patanè

10.1016/j.ijcard.2016.08.043

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Citations (0)

Detection of Parietaria judaica airborne allergenic activity: comparison between immunochemical and morphological methods including clinical evaluation

Clinical & Experimental Allergy (1994)

Gennaro D’Amato Maria Donatella Gentili María Julieta Russo G. Mistrello Maria Saggese

Abstract. Airborne pollen grains und small plant particles of respirable size are the main causes of rhinitis and asthma in pollinosis patients. Consequently, it could be useful to quantify atmospheric variations in these biological aerosols and their allergenic activity as a basis for establishing correlations with the clinical symptoms in these allergic subjects. Our study was conducted in Naples from May to August 1992 and from May to August 1993 and concentrated on Perietaria judaica (Par j ) the most important hay fever‐provoking plant in southern Italy. The aim of this study was lo evaluate the day‐to‐day variation in counts of Par j. pollen, the day‐to‐day variation in allergenic activity specific for this plant, and to relate these two variables to symptom scores in patients with respiratory allergy to Par j. The airborne pollen grains were collected by a Hirst‐like volumetric trap and examined through an optical microscope, while the allergenic activity of particles trapped on glass fibre filters in a high volume air‐sampler was determined by immunochemical assay. The two devices were placed on the flat roof of the “A. Cardarelli” Hospital. The results of this preliminary study suggest that both methods could have useful clinical relevance, since these two biological parameters were significantly correlated with the symptom scores of allergic patients. However, pollen count with morphological quantification of grains/m 3 of air is a more simple technique.

Hay fever

Aeroallergen

Airborne allergen

10.1111/j.1365-2222.1994.tb00954.x

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Citations (29)

Multi-Criteria Decision Analysis to prioritize hospital admission of patients affected by COVID-19 in low-resource settings with hospital-bed shortage

International Journal of Infectious Diseases (2020)

Pasquale De Nardo Elisa Gentilotti Fulvia Mazzaferri Eleonora Cremonini Paul Hansen

ObjectiveTo use Multi-Criteria Decision Analysis (MCDA) to determine weights for eleven criteria in order to prioritize COVID-19 non-critical patients for admission to hospital in healthcare settings with limited resources.MethodsThe MCDA was applied in two main steps: specification of criteria for prioritizing COVID-19 patients (and levels within each criterion); and determination of weights for the criteria based on experts' knowledge and experience in managing COVID-19 patients, via an online survey. Criteria were selected based on available COVID-19 evidence with a focus on low- and middle-income countries (LMICs).ResultsThe most important criteria (mean weights, summing to 100%) are: PaO2 (16.3%); peripheral O2 saturation (15.9%); chest X-ray (14.1%); Modified Early Warning Score-MEWS (11.4%); respiratory rate (9.5%); comorbidities (6.5%); living with vulnerable people (6.4%); body mass index (5.6%); duration of symptoms before hospital evaluation (5.4%); CRP (5.1%); and age (3.8%).ConclusionsAt the beginning of a new pandemic, when evidence for disease predictors is limited or unavailable and effective national contingency plans are difficult to establish, the MCDA prioritization model could play a pivotal role in improving the response of health systems.

Prioritization

Pandemic

Economic shortage

Hospital admission

10.1016/j.ijid.2020.06.082

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Citations (68)

Adults ingesting a foreign body: how to manage it in ER

Emergency Care Journal (2009)

S Cuneo Valentina Canepa Stefania Vignolo Susy Laforge Maria Saggese

Ingestion of a foreign body is a relatively frequent reason to seek treatment in the Emergency Department and it is often treated based on the personal experience of the Emergency physician. It is the authors’ opinion that a definition to identify levels of risk should be developed so as to pursue the best strategic therapy. The Emergency Department doctor must eliminate the possibility of major complications due to aspiration, perforation, occlusion, etc. and prevent them from occurring by early identification and localization of the object ingested. This results in identifying patient treatment: either emergency treatment, deferred emergency treatment or home observation with a regular medical visit follow-up. Pediatric cases present significant diversity in both epidemiology and treatment and therefore must be treated separately from adult cases.

Perforation

Emergency treatment

Medical treatment

10.4081/ecj.2009.4.11

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Citations (1)