Bingtian Dong

First Affiliated Hospital of Anhui Medical University

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Huaming Wang

Gansu Provincial Hospital

Guorong Lyu

Quanzhou Normal University

Shaozheng He

Fujian Medical University

Xi Lin

Fujian Provincial Cancer Hospital

Guorong Lyu

Second Affiliated Hospital of Fujian Medical University

Yuping Chen

State Key Laboratory of Digital Medical Engineering

Zecheng Wang

East China University of Technology

Yongjian Chen

Southern Medical University

Ivica Grgurević

University Hospital Dubrava

Liting Zhang

Florida State University

Cooperative Institutions

Fujian Medical University

Second Affiliated Hospital of Fujian Medical University

Capital Medical University

Zhejiang University

Zhongda Hospital Southeast University

Anhui Medical University

Nanjing Medical University

Shanghai Jiao Tong University

Chinese Academy of Medical Sciences & Peking Union Medical College

Lanzhou University

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Use of Sound Touch Elastography and Sound Touch Quantification for the Noninvasive Evaluation of Portal Hypertension in a Rat Model

Journal of Ultrasound in Medicine (2023)

Bingtian Dong Guorong Lyu Huaming Wang Yongjian Chen Kaipeng Wei

Objectives In this study, we used the recently developed ultrasound elastography techniques sound touch elastography (STE) and sound touch quantification (STQ) to quantify portal hypertension (PHT) severity in a rat model of carbon tetrachloride (CCl 4 )‐induced cirrhotic PHT. Methods In total, 60 rats were used. Various degrees of PHT were established. Liver and spleen stiffness were measured by STE (L‐STE and S‐STE, respectively) and STQ (L‐STQ and S‐STQ, respectively). We measured portal pressure (PP) after ultrasonographic examination. The performance of the STE and STQ parameters in the identification of PHT was evaluated using receiver operating characteristic (ROC) analyses. Results Liver and spleen stiffness measurements obtained with STE and STQ correlated positively with the PP ( r = 0.566–0.882, all P < .001). The areas under ROC curves for L‐STE, S‐STE, L‐STQ, and S‐STQ values were 0.931 (95% confidence interval [CI], 0.847–1.000), 0.982 (95% CI, 0.956–1.000), 0.796 (95% CI, 0.680–0.912), and 0.925 (95% CI, 0.858–0.993), respectively, for PP ≥5 mmHg; 0.937 (95% CI, 0.865–1.000), 0.938 (95% CI, 0.864–1.000), 0.967 (95% CI, 0.923–1.000), and 0.960 (95% CI, 0.897–1.000), respectively, for PP ≥10 mmHg; and 0.954 (95% CI, 0.897–1.000), 0.790 (95% CI, 0.652–0.928), 0.808 (95% CI, 0.680–0.935), and 0.740 (95% CI, 0.595–0.885), respectively, for PP ≥12 mmHg. Conclusions STE and STQ are reliable noninvasive tools for the assessment of PHT severity, especially for PP ≥10 mmHg, in a rat model of CCl 4 ‐induced cirrhotic PHT.

10.1002/jum.16172

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Carvedilol to prevent hepatic decompensation of cirrhosis in patients with clinically significant portal hypertension stratified by new non-invasive model (CHESS2306)

Clinical and Molecular Hepatology (2024)

Chuan Liu Hong You Qing‐Lei Zeng Yu Jun Wong Bingqiong Wang

Non-invasive models stratifying clinically significant portal hypertension (CSPH) are limited. Herein, we developed a new non-invasive model for predicting CSPH in patients with compensated cirrhosis and investigated whether carvedilol can prevent hepatic decompensation in patients with high-risk CSPH stratified using the new model.

Carvedilol

Decompensation

10.3350/cmh.2024.0198

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Citations (3)

Identification of Potential miRNA-mRNA Regulatory Network in Tetralogy of Fallot: A Network Biology Approach

Research Square (Research Square) (2021)

Huaming Wang Guorong Lyu Shaozheng He Xi Lin Bingtian Dong

Abstract BackgroundTetralogy of Fallot (ToF) is one of the most prevalent and fatal birth defects. Its pathogenesis remains unknown and it’s not easily diagnosed at early stage. Therefore, it’s necessary to explore the critical regulators and molecular mechanism in ToF to find out novel molecular markers for early diagnosis.MethodsThree ToF datasets (GSE35490, GSE40128, GSE36761) were downloaded from the GEO database. The differentially expressed microRNAs (DEMs) and mRNAs (DEGs) were identified between ToF infants and normal infants after data preprocessing, followed by GO and KEGG analysis of DEGs. Then, PPI network and modular analysis were performed to identify the hub genes. Ultimately, potential miRNA-mRNA pathways in ToF were constructed based on the integrated data.Results22 overlapping DEMs were found in the GES35490 and GSE40128. Simultaneous, 181 intersected genes were found and identified as the significant DEGs including 84 down-regulated DEGs and 97 up-regulated DEGs. Further, 20 hub genes ranked by top 10% with high connectivity, including STAT3, FBN1, RUNX2, were found by PPT network and modular analysis. Furthermore, GO and KEGG analysis showed these DEGs were linked to cell cycle, apoptotic process, transcription activity and FOX signaling pathway. Additionally, we establish three potential miRNA-mRNA pathway, including miR-22-STAT3, miR-336/miR486-FBN1, miR-222-RUNX2, which can participate in the formation of ToF by cell cycle and transcription activity.ConclusionsThree miRNA-mRNA pathways were established and indicated cell cycle and transcription activity may be involved in the pathogenesis of ToF. Our study provided a novel bio-marker for early diagnosis of ToF.

KEGG

Gene regulatory network

10.21203/rs.3.rs-506395/v1

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Diagnostic accuracy of contrast-enhanced ultrasound for detecting clinically significant portal hypertension and severe portal hypertension in chronic liver disease: a meta-analysis

Figshare (2023)

Yayang Duan Bingtian Dong Siyao Li Chaoxue Zhang

Contrast-enhanced ultrasound (CEUS) has been proposed for detecting clinically significant portal hypertension (CSPH) and severe portal hypertension (SPH) in patients with chronic liver diseases (CLD). Studies were selected that investigated the diagnostic performance of CEUS in patients with CLD up to 10 October 2022. The summary area under the receiver operating characteristic curve (AUROC), the summary diagnostic odds ratios, and the summary sensitivities and specificities were used to assess the performance of CEUS for detecting CSPH and SPH. A total of 7 studies were included in this meta-analysis. The summary sensitivity and specificity of this method for CSPH were 92% (95% confidence interval (CI), 76%–97%) and 78% (95% CI, 67%–86%), respectively, and the summary AUROC was 0.89 (95% CI, 0.86–0.92). Those for SPH were 81% (95% CI, 60%-93%), 82% (95% CI, 76%-86%), and 0.82 (95% CI, 0.79–0.85), respectively. A subgroup analysis of 3 subharmonic aided pressure estimation (SHAPE) studies revealed similar diagnostic performance (sensitivity: 95%; specificity: 74%; AUROC: 0.93) for detecting CSPH. CEUS shows good performance in diagnosing CSPH as well as SPH. SHAPE technique may play a more important role in evaluating CSPH in the future. The meta-analysis was not registered.

Chronic liver disease

Contrast-enhanced ultrasound

10.6084/m9.figshare.22352667

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Two-dimensional shear wave elastography: a new tool for evaluating respiratory muscle stiffness in chronic obstructive pulmonary disease patients

BMC Pulmonary Medicine (2022)

Yongjian Chen Jingyun Li Bingtian Dong Zhixing Zhu Guorong Lyu

Abstract Background Impaired respiratory function caused by respiratory muscle dysfunction is one of the common consequences of chronic obstructive pulmonary disease (COPD). In this study, two-dimensional shear wave elastography (2D-SWE) was used to measure diaphragm stiffness (DS) and intercostal muscle stiffness (IMS) in patients with COPD; in addition, the value of 2D-SWE in evaluating respiratory function was determined. Methods In total, 219 consecutive patients with COPD and 20 healthy adults were included. 2D-SWE was used to measure the DS and IMS, and lung function was also measured. The correlation between respiratory muscle stiffness and lung function and the differences in respiratory muscle stiffness in COPD patients with different severities were analysed. Results 2D-SWE measurements of the DS and IMS presented with high repeatability and consistency, with ICCs of 0.756 and 0.876, respectively, and average differences between physicians of 0.10 ± 1.61 and 0.07 ± 1.65, respectively. In patients with COPD, the DS and IMS increased with disease severity (F 1 = 224.50, F 2 = 84.63, P < 0.001). In patients with COPD, the correlation with the forced expiratory volume in one second (FEV 1 )/forced vital capacity (FVC), predicted FEV 1 % value, residual volume (RV), total lung capacity (TLC), RV/TLC, functional residual capacity (FRC) and inspiratory capacity (IC) of DS (r 1 =-0.81, r 2 =-0.63, r 3 = 0.65, r 4 = 0.54, r 5 = 0.60, r 6 = 0.72 and r 7 =-0.41, respectively; P < 0.001) was stronger than that of IMS (r 1 =-0.76, r 2 =-0.57, r 3 = 0.57, r 4 = 0.47, r 5 = 0.48, r 6 = 0.60 and r 7 =-0.33, respectively; P < 0.001). Conclusion 2D-SWE has potential for use in evaluating DS and IMS. A specific correlation was observed between respiratory muscle stiffness and lung function. With the worsening of the severity of COPD and the progression of lung function impairment, the DS and IMS gradually increased.

Vital capacity

Diaphragm (acoustics)

10.1186/s12890-022-02231-4

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Citations (4)

[Dynamic study on blood lead levels of pregnant women and infants in a district of Beijing].

PubMed (1997)

Jianjun Liu Qin Xin Xiaohong Bai Bingtian Dong Tao Ye

Under strict quality control, the authors investigated the levels of PbB among 270 women from early pregnancy to delivery and their infants. The mean PbB levels of the first three months of pregnancy and delivery is 45.0 microg/L and 64.8 microg/L respectively. Analysis shows an increase of mean PbB level in the period of gestation, and a significant increase in the last three months. The mean PbB level of umbilical cord is 51.9 microg/L (10.4% umbilical cord PbB > 100 microg/L). The mean PbB level of infants increases with the months, it increases significantly after six months. Regression analysis confirmed the positive correlation between the PbB levels of first three and second three months of gestation, the PbB of delivery and umbilical cord, the PbB of umbilical coral and infants. The correlation coefficient of the PbB level of delivery and umbilical cord, the PbB level of infants at six months and at twelve months is 0.80 and 0.47 respectively.

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[A case of fatal cryptococcoisis, as a primary disease, with bronchopulmonary and septicemic beginnings and multivisceral, mostly intra-cardiac and intra-aortic localization].

PubMed (1975)

Pavin Trinh Tran Vinh Hien Bingtian Dong L. Lan Nguyen Danh Hong

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Peer Review #4 of "Differential lncRNA/mRNA expression profiling and ceRNA network analyses in amniotic fluid from foetuses with ventricular septal defects (v0.2)"

Huaming Wang Xi Lin Zecheng Wang Shaozheng He Bingtian Dong

Background.Long noncoding RNAs (lncRNAs) have been shown to be involved in the regulation of numerous biological processes in embryonic development.We aimed to explore lncRNA expression profiles in ventricular septal defects (VSDs) and reveal their potential roles in heart development.Methods.Microarray analyses were performed to screen differentially expressed lncRNAs (DE-lncRNAs) and mRNAs (DE-mRNAs) in the amniotic fluid between the VSD group and the control group.Bioinformatics analyses were further used to identify the functional enrichment and signaling pathways of important mRNAs.Then, a coding-noncoding gene coexpression (CNC) network and competitive endogenous RNAs (ceRNA) network were drawn.Finally, qRT-PCR was performed to verify several hub lncRNAs and mRNAs in the network. Results.A total of 710 DE-lncRNAs and 397 DE-mRNAs were identified in the VSD group.GO and KEGG analyses revealed that the DE-mRNAs were enriched in cardiac development-related biological processes and pathways, including cell proliferation, cell apoptosis, and the Sonic Hedgehog signaling pathway.Four VSD related mRNAs was used to construct the CNC network, which included 149 pairs of coexpressing lncRNAs and mRNAs.In addition, a ceRNA network, including 15 lncRNAs, 194 miRNAs, and 4 mRNAs, was constructed to reveal the potential regulatory relationship between lncRNAs and proteincoding genes.Finally, seven RNAs in the ceRNA network were validated, including IDS, NR2F2, GPC3, LINC00598, GATA3-AS1, PWRN1, and LINC01551. Conclusion.Our study identified some lncRNAs and mRNAs may be potential biomarkers and therapeutic targets for foetuses with VSD, and described the lncRNA-associated ceRNA network in the progression of VSD.

Competing Endogenous RNA

Profiling (computer programming)

10.7287/peerj.14962v0.2/reviews/4

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Liver stiffness measurement as a quantitative method for liver fibrosis in children with non‐alcoholic fatty liver disease: A meta‐analysis

Journal of Paediatrics and Child Health (2021)

Bingtian Dong Yuping Chen Guorong Lyu Ran Qin

This study assessed the diagnostic performance of liver stiffness measurement (LSM) in detecting liver fibrosis in paediatric patients with non-alcoholic fatty liver disease (NAFLD) through meta-analysis.Online database searches of PubMed, EMBASE, the Cochrane Library and the Web of Science were conducted for studies that evaluated the performance of LSM for diagnosing liver fibrosis in paediatric patients with NAFLD until 1 January 2021. The Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool was used to assess the quality of the included studies. Three measures were used to assess the performance of LSM for detecting liver fibrosis in paediatric patients with NAFLD, including the summary sensitivities and specificities, the summary area under the receiver operating characteristic curves and the summary diagnostic odds ratios.Our final data included seven studies with a total of 436 paediatric patients with NAFLD for meta-analysis. The overall prevalence of mild fibrosis, significant fibrosis, advanced fibrosis and cirrhosis was 66.3, 31.5, 14.9 and 1.2%, respectively. The summary sensitivity, specificity and area under the receiver operating characteristic values of LSM were 80, 92 and 0.94 for the prediction of mild fibrosis; 91, 97 and 0.98 for the prediction of significant fibrosis; and 89, 93 and 0.96 for the prediction of advanced fibrosis, respectively.Liver stiffness measurement exhibited good diagnostic performance in predicting liver fibrosis and can be used as a non-invasive tool in the management of paediatric patients with non-alcoholic fatty liver disease.

Diagnostic odds ratio

Chronic liver disease

Liver disease

10.1111/jpc.15751

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Citations (6)

[Comparison between the efficiency of two-dimensional shear-wave elastography and four serum fibrosis indicators for the assessment of liver fibrosis in chronic hepatitis B].

PubMed (2020)

Bingtian Dong S. L. HUANG Jiandong Chang Jianping Yan Rujun Lin

选取102例慢性乙型肝炎患者，以超声引导下肝组织穿刺病理学结果为金标准，使用声触诊弹性成像（STE）技术检测肝弹性模量值（kPa），并选取4项血清纤维化指标评估肝纤维化程度，包括天冬氨酸转氨酶/血小板比值指数（APRI）、FIB-4、Forns指数、King’s评分。结果显示STE与肝纤维化分期的Spearman相关性及STE诊断各期肝纤维化的受试者工作特征曲线下面积均高于血清生物化学指标，STE较血清纤维化指标在评估肝纤维化方面更具优势，且检查无创实时、简便易行，值得推广。.

Hepatic fibrosis

Transient elastography

10.3760/cma.j.cn501113-20190313-00083

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