Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A. Address correspondence and reprint requests to Aaron Remenschneider, M.D., Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114; E-mail: [email protected] The authors disclose no conflicts of interest.

Otology

Neurotology

Laryngology

10.1097/mao.0b013e31829c1125

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Citations (4)

Lipochoristoma of the Internal Auditory Canal

Journal of Neurological Surgery Reports (2015)

Aaron K. Remenschneider Felipe Santos George Scangas

Approximately 90% of tumours of cerebellopontine angle and internal auditory canal are vestibular schwannomas (acoustic neuromas) and meningiomas. Lipochoristomas are rare benign masses that represent only 0.15% of cases.We report the case of a 39-year-old man who consulted us for right-sided hearing loss and tinnitus.Tonal audiometry showed a down-sloping right sensorineural hearing loss in frequencies above 2000 Hz. Magnetic resonance imaging (MRI) revealed a heterogeneous lesion in the right internal auditory canal with areas of hyperintensity on noncontrast T1-weighted MRI and suppression of much of the signal of the lesion with persistence of some areas of enhancement on T1-weighted fat-suppressed images.Correct imaging diagnosis through MRI (high signal intensity on noncontrast T1-weighted images together with a missing signal in fat suppression sequences) is essential in order to avoid unnecessary surgery or radiation therapy, which are not recommended in the treatment of these lesions.

10.1055/s-0034-1396654

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Citations (6)

En la escalera de Tribschen

Nueva revista de política, cultura y arte/Nueva revista de política, cultura y arte (2008)

Felipe Santos

Source

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Citations (0)

Temporal bone histopathology of furosemide ototoxicity

Laryngoscope Investigative Otolaryngology (2017)

Felipe Santos Joseph B. Nadol

Objectives To describe the human temporal bone pathology in two patients who incurred furosemide induced ototoxicity. Patients 1) A 46‐year‐old woman in acute liver and renal failure treated with high doses of furosemide for anasarca who developed a rapidly progressive severe‐to‐profound asymmetric sensorineural hearing loss. 2) A 65‐year‐old woman with undifferentiated small cell carcinoma of the lung who received intravenous furosemide 1 day prior to death for pulmonary edema. Interventions Removal of temporal bones, histologic processing, and light microscopy of temporal bones. Main Outcome Measures Temporal bone histopathology and correlation with clinical and audiometric data. Results All three temporal bones demonstrated edema and cystic changes in the stria vascularis. In the first case the furosemide exposure was associated with hearing loss and the pathological changes were more extensive including cystic changes in the Hensen's cells, collapse of Reissner's membrane and the tectorial membrane and diffuse loss of inner and outer hair cells with only modest reduction in the spiral ganglion cell population. In the second case, without attributable hearing loss, there was only modest reduction in hair cell and spiral ganglion cell counts. Pathological changes were not observed in the ampullae of the semicircular canals or epithelium of the saccular or utricular maculae in either case. Conclusions The temporal bone pathologic correlate for furosemide‐induced ototoxicity is edema and cystic degeneration of the stria vascularis. The degree of degenerative change appears dose‐dependent. We infer that pathological changes may occur in the absence of a measurable immediate clinical effect. Level of Evidence NA.

Spiral ganglion

Ototoxicity

Saccule

Endolymphatic hydrops

Histopathology

Modiolus (cochlea)

10.1002/lio2.108

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Citations (18)

Drug screening for hearing loss: Using the zebrafish lateral line to screen for drugs that prevent and cause hearing loss

Drug Discovery Today (2010)

Henry C. Ou Felipe Santos David W. Raible Julian A. Simon Edwin W. Rubel

Ototoxicity

10.1016/j.drudis.2010.01.001

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Citations (96)