Cristina Canzi

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Felicia Zito

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Paolo Gerundini

University of Milan

Franco Voltini

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Massimo Castellani

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Virgilio Longari

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

P. Gerundini

University of Milan

Eugenio Reschini

Ospedale Maggiore

Roberta Matheoud

Azienda Ospedaliero Universitaria Maggiore della Carita

Riccardo Benti

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Elisabetta De Bernardi

University of Milano-Bicocca

Cooperative Institutions

University of Milan

Istituti di Ricovero e Cura a Carattere Scientifico

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Ospedale Maggiore

Istituto Nazionale di Fisica Nucleare

Luigi Sacco Hospital

IRCCS Policlinico San Donato

University of Florence

Istituto Nazionale di Fisica Nucleare, Sezione di Milano

Sapienza University of Rome

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

The Role of PET with ¹³N-Ammonia and ¹⁸F-FDG in the Assessment of Myocardial Perfusion and Metabolism in Patients with Recent AMI and Intracoronary Stem Cell Injection

Journal of Nuclear Medicine (2010)

Massimo Castellani Alessandro Colombo Rosaria Giordano Enrico Pusineri Cristina Canzi

Acute neurocognitive and balance effects, and reported health complaints such as vertigo related to static magnetic fields (SMF) from magnetic resonance imaging (MRI) devices were the reason to study the effects of these exposures on the occurrence of accidents. In this first retrospective cohort study among workers from a facility producing medical imaging devices we studied the association between SMF and occurrence of accidents in general and during commuting.

Methods

SMF exposure was assessed with a manufacturing facility specific historical job exposure matrix linked to company records on individual job histories, resulting in two SMF exposure measures: exposure in the year of a self-reported accident (recent exposure) and cumulative exposure up to the end of the year an accident was reported (career exposure). Data on occurrence of accidents was collected through an online questionnaire (1479 participants, participation rate 30%). Data on injuries and physician-treated injuries due to accidents in the past 12 months were analysed with logistic regression. Discrete-time survival analysis was applied to historic data on the reported year of the first ever (near) traffic accident during commute to and from work.

Results

High recent SMF exposure was found to be related to an increased risk of accidents leading to injury (Odds Ratio 4.39, 95% Confidence Interval 1.20–16.06) with a stronger effect for injuries treated by a physician (OR 6.28, 95%CI 1.70–23.26). High recent SMF exposure was associated with increased risk (Hazard Rate 3.21, 95% Confidence Interval 1.36–7.18) of (near) accidents during commute from home to work, but not from work. No increased risks were found with respect to career exposure after adjustment for recent exposure.

Conclusion

This retrospective cohort study among workers exposed to MRI-related SMF showed that recent SMF exposure is associated with increased risks of accidents resulting in injuries and (near) traffic accidents during commute from home to work.

10.2967/jnumed.110.078469

Cite

Citations (36)

Potential third‐party radiation exposure from outpatients treated with for hyperthyroidism

Medical Physics (2004)

Roberta Matheoud Eugenio Reschini Cristina Canzi Franco Voltini Paolo Gerundini

Thirty‐three hyperthyroid patients treated with radioiodine (mean administered activity 414 MBq, range 163–555) were studied to determine if pretreatment dosimetry could be used to give radiation protection advice that could assure compliance with the effective dose constraints suggested by the European Commission. Effective doses to travelers, co‐workers, and sleeping partners were estimated by integrating the effective dose rate‐versus‐time curve obtained by fitting the dose rates measured several times after radioiodine administration to a biexponential function. The mean estimated effective doses to travelers, co‐workers, and sleeping partners were 0.11 mSv (0.05–0.24), 0.24 mSv (0.07–0.52), and 1.8 mSv (0.6–4.1), respectively. The best correlation was found between effective dose in mSv and maximum activity in MBq taken up in the thyroid: ; ; . Private/public transports are always allowed. For the co‐workers the effective dose constraint of 0.3 mSv is met without restrictions and with 3 days off work if is lower or higher than 185 MBq, respectively. For the sleeping partners the effective dose constraint of 3 mSv is met without restriction and with 4 nights separate sleeping arrangements if is lower or higher than 185 MBq, respectively. The potential for contamination by the patients was determined from perspiration samples taken from the patient's hands, forehead, and neck and in saliva at 4, 24, and 48 h after radioiodine treatment. The mean highest activity levels for hands, forehead, neck, and saliva were , and , respectively. The results indicate that there is minimal risk of contamination from these patients.

Radioiodine therapy

Cumulative dose

Equivalent dose

European commission

10.1118/1.1809781

Cite

Citations (15)

Tissue-specific dosimetry for radioiodine therapy of the autonomous thyroid nodule

Medical Physics (2003)

Roberta Matheoud Cristina Canzi Eugenio Reschini Felicia Zito Franco Voltini

A tissue-specific dosimetric method based on gamma camera acquisitions was developed to determine the activity to administer to patients with autonomous thyroid nodules (ATN) to deliver 200 Gy to the nodule and to evaluate the correspondent dose to extranodular tissue. Twenty patients with ATN were given 111 MBq of i.v. and their neck was imaged 2, 4, 24, 48, and 120 hours after administration to evaluate separate iodine kinetics for nodule and contralateral lobe. The volumes of nodule and lobe were measured on the 4 hour scintigraphic image, after optimization of the method on a thyroid phantom. Three simplified dosimetric methods were then considered and compared to the reference method in terms of activity: (a) three point method, based on 4, 24, and 120 h acquisitions, (b) fixed method, that measures only the 24 h uptake and assumes an effective half-life of 5 days for the nodule, (c) fixed activity method, based on the administration of 413 MBq of The mean activity to administer to the 20 patients was 413 MBq (range 65–1327) and the mean dose to the contralateral lobe was 43 Gy (range 11–121). The percentage differences in activity between the reference method and the simplified methods were in the ranges: (a) −14%, 13%, (b) −42%, 74%, (c) −69%, 533%. The relevant dose to extranodular tissue and the great interpatient variability of the radioiodine activity required to give a predetermined dose to ATN suggest that a tissue specific dosimetric approach based on gamma camera acquisitions is fundamental. A simple method based on only three uptake measurements is a reliable alternative to the five point method when the clinical workload of a Nuclear Medicine department is particularly heavy.

Nodule (geology)

Iodine-123

10.1118/1.1567270

Cite

Citations (19)

Radiation protection impact of radioiodine therapy for hyperthyroidism after a patient specific dosimetric study

Physica Medica (2016)

Cristina Canzi Virgilio Longari Massimo Castellani Roberto Lambertini Felicia Zito

Radioiodine therapy

10.1016/j.ejmp.2016.01.347

Cite

Citations (0)

Verification of the agreement of two dosimetric methods with radioiodine therapy in hyperthyroid patients

Medical Physics (2006)

Cristina Canzi Felicia Zito Franco Voltini Eugenio Reschini Paolo Gerundini

The aim of this study was to verify the capability of an MIRD formula-based dosimetric method to predict radioiodine kinetics (fraction of administered iodine transferred to the thyroid, , and effective clearance rate, ) and absorbed dose after oral therapeutic administration. The method is based on intravenous administration and five subsequent gamma camera measured uptake values determined separately on different structures within the thyroid. Another dosimetric method based on only the 24-h uptake and a fixed value was also considered. Eighty-nine hyperthyroid patients (10 with Graves' disease and 79 with autonomously functioning nodules) were studied and 132 thyroidal structures were evaluated. The mean time interval between dosimetry and therapy was . Uptake values were measured at 2, 4, 24, 48, and during dosimetry and at 2, 4, 24, 48, 96, and during therapy. The value was chosen in the fixed- method. The planned doses to the target ranged from 120 to depending on the type and severity of hyperthyroidism. The following significant correlations between therapeutic and dosimetric parameters were found: , , and . The percent difference between and ranged from to 32% and between and from to 48%. was lower than in 74% of cases: this can be explained by the self-stunning effect of therapeutic activity that produced a dose of about with a maximum dose rate of over the initial . The differences, , between the estimated and the planned doses ranged from to 32% ; in 73% of cases the difference was within . Greater discrepancies were found with the fixed- method, in which ranged from to 95% ( to , respectively). In hyperthyroid patients, the five uptake value dosimetric method is able to predict with a good agreement the radioiodine kinetics and the dose after the therapeutic administration in about 73% of the analyzed thyroid structures. The fixed- method is less reliable.

Radioiodine therapy

Therapeutic index

10.1118/1.2210564

Cite

Citations (28)

A feasibility study for a hadron therapy facility

Physica Medica (1993)

U. Amaldi G. Arduini Cristina Canzi C. Furetta Riccardo Leone

Source

Cite

Citations (0)

Is the time of TSH normalization after radioiodine treatment for thyroid autonomies related to the maximum dose rate to the target

Journal of Nuclear Medicine (2008)

Marco Carletto Cristina Canzi Massimo Castellani Virgilio Longari Paolo Gerundini

1042 Objectives: The response to radioiodine treatment for uni or multifocal autonomy (UA, MA) is unpredictable and factors influencing the response to therapy are unknown. Aim of this study is to explore the correlation between the maximum dose rate to the target nodules and the time of normalization of TSH. Methods: We audited clinical outcome in 125 pts.(f:90 m:35; mean age 66±11 yrs) treated with 131I over the last six years (mean activity 372±134 MBq). UA (41%) and MA (59%) were defined by the existence of one or more hot nodules at scintigraphy in presence of overt or subclinical hyperthyroidism. The maximum dose rate (Gy/h) and the total delivered dose to the nodules were calculated through multiple uptake determinations on γ-camera images; in multifocal autonomies only the dominant nodule was considered. Results: On the basis of the maximum dose rate values the patients were divided into two groups, superior (G1) and inferior (G2) to the median value which was 0.66 Gy/h. In G1 (mean maximum rate 0.90 Gy/h) the time of normalization of TSH was 2.5 months, while in G2 (mean maximum rate 0.50 Gy/h) it was 7.8 months (p Conclusions: Our data suggest that the maximum dose rate to the target nodule is strictly related to the time of normalization of TSH value. The maximum dose rate could be a new parameter to consider in therapy planning.

Subclinical infection

Normalization

Radioiodine therapy

Dose rate

Nodule (geology)

Source

Cite

Citations (0)

13N-NH3 PET: The assessment of myocardial perfusion in patients with AMI and stem cell therapy

Massimo Castellani Cristina Canzi Virgilio Longari Rosaria Giordano Davide Soligo

7 Objectives: To assess the changes of myocardial perfusion after intracoronary bone marrow stem cells injection following a recent AMI. Methods: Fifteen patients (14M; mean age: 52 yrs; range: 30-64) were enrolled within 7 days after ST segment elevation AMI. The patients were randomly submitted to intracoronary injection of cells derived from autologous bone marrow (BM;5) or mobilized from peripheral blood (PB;5); the remaining 5 patients were treated with standard medical therapy alone and considered as controls (C). 13N-NH3 PET study was performed within 7 days after AMI and after 12 months from therapy. The 13N-NH3 uptake in infarct related segments was assessed on a 9-region model polar map of the heart with 5-level uptake score (summed rest score;SRS). The infarct size (IS) was expressed as the percentage of the polar map with a tracer uptake lower than 50% of the maximum. The myocardial blood flow (MBF) was calculated by means of Munich Heart software and expressed in mL/mg/min. Results: At present, 12/15 patients completed the study and a decrease of the SRS was observed in all groups, although a more pronounced reduction was seen in BM group (table). Accordingly, a major decrease in infarct size was seen in these patients. The improvement of MBF was observed in the infarct-related areas of BM group whereas a moderate or mild decrease was respectively seen in PB and C patiens. A re-infarction occurred in 1 PB patient, whereas one C patient underwent heart transplantation. Stable clinical conditions were noted in the remaining 10 patients. Conclusions: 13N-NH3 PET is able to detect the changes of myocardial perfusion in patients with and without intracoronary bone marrow stem cells injection. The reduction of perfusion in PB patients should be considered in the treatment of AMI with bone marrow stem cells therapy.

Stem Cell Therapy

Cite

Citations (1)

Changes in the energy response of a dedicated gamma camera after exposure to a high-flux irradiation

Physics in Medicine and Biology (1999)

Roberta Matheoud Felicia Zito Cristina Canzi Franco Voltini Paolo Gerundini

This work reports the effects of the gain variation of the photomultiplier tubes (PMTs) observed on a cardiac dedicated gamma camera after accidental high-flux irradiation. One detector of this dual-headed 90°-fixed gamma camera was accidentally left uncollimated during a quality assurance procedure on the other detector with a 57Co flood source (259 MBq) and received a non-uniform high flux of 1.9-0.6 Mcps over 25 000 mm2 areas for about 30 min. To evaluate the severity and the duration of the perturbation effect on the energy response of the detector, the photopeak position was monitored for about 1 month with a 99mTc point source. The 140 keV photopeak shifted to 158 keV soon after irradiation, reached the correct position after 9 days and moved to a stable value of 132 keV after 15 days. Afterwards, a new energy calibration reset the photopeak position at 140 keV and the correct energy response of the gamma camera. This experience suggests that particular care should be taken to avoid exposures to high radiation fluxes that induce persistent gain shifts on the PMTs of this system.

Gamma Irradiation

10.1088/0031-9155/44/6/408

Cite

Citations (4)

EANM Dosimetry Committee Series on Standard Operational Procedures for Pre-Therapeutic Dosimetry II. Dosimetry prior to radioiodine therapy of benign thyroid diseases

European Journal of Nuclear Medicine and Molecular Imaging (2013)

Heribert Hänscheid Cristina Canzi W. Eschner Glenn Flux Markus Luster

Radioiodine therapy

Internal dosimetry

Radionuclide therapy

10.1007/s00259-013-2387-x

Cite

Citations (127)