With its sequential image acquisition, OCT-based corneal topography is often susceptible to measurement errors due to eye motion. We have developed a novel algorithm to detect eye motion and minimize its impact on OCT topography maps. We applied the eye motion correction algorithm to corneal topographic scans acquired using a 70 kHz spectral-domain OCT device. OCT corneal topographic measurements were compared to those from a rotating Scheimpflug camera topographer. The motion correction algorithm provided a 2-4 fold improvement in the repeatability of OCT topography and its agreement with the standard Scheimpflug topographer. The repeatability of OCT Zernike-based corneal mean power, cardinal astigmatism, and oblique astigmatism after motion detection was 0.14 D, 0.28 D, and 0.24 D, respectively. The average differences between the two devices were 0.19 D for simulated keratometry-based corneal mean power, 0.23 D for cardinal astigmatism, and 0.25 D for oblique astigmatism. Our eye motion detection method can be applied to any OCT device, and it therefore represents a powerful tool for improving OCT topography.
Purpose: To measure the deformation of the porcine optic nerve head (ONH) and peripapillary sclera (PPS) in response to intraocular pressure (IOP) elevation. Methods: High-frequency ultrasound was used to image the ONH and PPS of 12 porcine eyes during ex vivo inflation testing from 5 to 30 mm Hg. A speckle tracking algorithm was used to compute tissue displacements in the anterior-posterior direction and expansion of the scleral canal. Through-thickness, in-plane, and shear strains were calculated within the ONH. Regional displacements and strains were analyzed and compared. Results: The ONH and PPS showed overall posterior displacement in response to IOP elevation. Posterior displacement of the ONH was larger than and strongly correlated with the posterior displacement of the PPS throughout inflation testing. Scleral canal expansion was much smaller and leveled off quicker than ONH posterior displacement as IOP increased. Through-thickness compression was concentrated in the anterior ONH, which also experienced larger in-plane and shear strains than the posterior ONH. Within the anterior ONH, all three strains were significantly higher in the periphery compared with the center, with the shear strain exhibiting the greatest difference between the two regions. Conclusions: High-resolution ultrasound speckle tracking revealed the full-thickness mechanical response of the posterior eye to IOP elevation. A mismatch in posterior displacement was found between the ONH and PPS, and regional analyses showed a concentration of strains within the periphery of the anterior porcine ONH. These deformation patterns may help in understanding IOP-associated optic nerve damage and glaucoma susceptibility.
Intraocular pressure (IOP) induced strains in the peripapillary sclera may play a role in glaucoma progression. Using inflation testing and ultrasound speckle tracking, the 3D strains in the peripapillary sclera were measured in nine human donor globes. Our results showed that the peripapillary sclera experienced through-thickness compression and meridional stretch during inflation, while minimal circumferential dilation was observed when IOP was increased from 10 to 19 mmHg. The maximum shear was primarily oriented in the through-thickness, meridional cross sections and had a magnitude slightly larger than the first principal strain. The tissue volume had minimal overall change, confirming near-incompressibility of the sclera. Substantial strain heterogeneity was present in the peripapillary region, with local high strain areas likely corresponding to structural heterogeneity caused by traversing blood vessels. These 3D strain characteristics provide new insights into the biomechanical responses of the peripapillary sclera during physiological increases of IOP. Future studies are needed to confirm these findings and investigate the role of these biomechanical characteristics in ocular diseases.
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