Abstract Two‐dimensional conjugated metal–organic frameworks (2D c ‐MOFs) are emerging as a unique subclass of layer‐stacked crystalline coordination polymers that simultaneously possess porous and conductive properties, and have broad application potential in energy and electronic devices. However, to make the best use of the intrinsic electronic properties and structural features of 2D c ‐MOFs, the controlled synthesis of hierarchically nanostructured 2D c ‐MOFs with high crystallinity and customized morphologies is essential, which remains a great challenge. Herein, we present a template strategy to synthesize a library of 2D c ‐MOFs with controlled morphologies and dimensions via insulating MOFs‐to‐ c ‐MOFs transformations. The resultant hierarchically nanostructured 2D c ‐MOFs feature intrinsic electrical conductivity and higher surface areas than the reported bulk‐type 2D c ‐MOFs, which are beneficial for improved access to active sites and enhanced mass transport. As proof‐of‐concept applications, the hierarchically nanostructured 2D c ‐MOFs exhibit a superior performance for electrical properties related applications (hollow Cu‐BHT nanocubes‐based supercapacitor and Cu‐HHB nanoflowers‐based chemiresistive gas sensor), achieving over 225 % and 250 % improvement in specific capacity and response intensity over the corresponding bulk type c ‐MOFs, respectively.
We report the assembly of four imidazolium bromides, each of which bears a naphthyl on one side of the imidazolium cation and a branched alkyl chain on the other. This design creates a new type of amphiphilic ionic liquid with an apolar–polar–apolar structure and a low melting point (mₚ, <−20 °C), which has not been achieved by reported counterparts bearing linear alkyl chains. In solvent-free states, microphase segregation occurs where polar and apolar domains arrange bicontinuously as proved by molecular dynamics (MD) simulations. When dispersed in water, self-stabilized giant aggregates formed with ultrahigh colloidal stability (up to years). MD simulations provide clues of discrete bicontinuous phases within the giant aggregates. These newly discovered self-assemblies provide a heterogeneous reservoir that can accommodate guest molecules including the highly apolar fullerene C₆₀, paving the way for a wide range of potential applications.
We investigated treatment with a receptor for advanced glycation endproduct (RAGE) blocking antibody on angiogenic response to hind limb ischemia in diabetic mice. Streptozotocin treated C57BL/6 mice received either murine monoclonal anti-RAGE F(ab′) 2 intraperitoneally ( n=10) or saline ( n=9) for 9 weeks. Diabetic plus 10 non-diabetic C57BL/6 mice underwent left femoral artery ligation and 5 days later angiogenesis imaging with 99m Tc-Arg–Gly–Asp (RGD) nanoSPECT/CT. Twenty-four days later, hind limb blood flow was measured with ultrasound, the mice were euthanized, and tissue was taken for immunohistochemistry. The angiogenic imaging signal in ischemic limbs was higher in RAGE-ab treated versus saline treated mice at day 5 (3.1±1.4 vs 1.68±0.35, p=0.02) and blood flow was higher at day 24 (1.49±0.5 vs 0.61±0.39, p=0.04). Immunohistochemistry of ischemic muscles showed greater capillary density in the RAGE-ab treated group versus the vehicle-treated group ( p<0.001) (NS from non-diabetic mice). In conclusion, treatment with anti-RAGE F(ab′) 2 in diabetic mice improves neovascularization in the ischemic leg.
Abstract Self‐assembly exploits noncovalent interactions to offer a facile and effective method for the construction of soft materials with multifunctionalities and diversity. In this work, fluorescence carbon quantum dots coordinated by Ce 3+ ions (CQDCe) have been synthesized and exploited as building blocks to generate a series of hierarchical structures through the ionic self‐assembly of CQDCe and biomolecules, namely DNA, myoglobin (Mb), and hyaluronic acid (HA). In particular, vesicles can be constructed by the simple mixing of oppositely charged CQDCe and DNA in water. The formation of unusual vesicles can be explained by the self‐assembly of CQDCe with a rearranged structure and the rigid DNA biomolecular scaffolds. This facile noncovalent self‐assembly method has inspired the innovative use of virgin DNA as a building block to construct vesicles rather than resorting to a sophisticated synthesis. The self‐assembly of CQDCe–biopolymers was accompanied by aggregation‐induced photoluminescence (PL) quenching. The biosensing platform was designed to detect polypeptides and deoxyribonuclease I through competitive binding of CQDCe and enzymatic hydrolysis of the DNA backbone, respectively. We believe that the integrative self‐assembly of CQDCe and DNA will enrich the theoretical study of vesicle formation by DNA molecules and extend the application of fluorescence carbon quantum dots in the biological field.
Thermotropic ionic liquid crystals of polyoxometalate (POM)-based ionic liquids (POM-based ILs), which are formed by a POM, K7PW11O39, and cationic surfactants, tetra-n-alkylammonium bromide ((CnH2n+1)4N+Br-, n = 6 and 7), are first proposed. As a model system, the cubic phase structure of a POM-based IL, {(C7H15)4N+}7PW11O39, was determined to form in a wide range of temperatures, exhibiting good thermostability, excellent mechanical strength, and high viscosity. Furthermore, the lyotropic ionic liquid crystals formed by {(C7H15)4N+}7PW11O39 in solvents such as chloroform or toluene still maintained a cubic structure. These cubic ionic liquid crystals (CILCs) were used as anticorrosion coatings both in acidic and neutral environments. The electrochemical measurements of Cu and Fe surfaces coated by CILCs showed an excellent ability of anticorrosion, indicating that the metals can be perfectly protected by the CILC coatings with high resistance and low capacitance. We assume that the CILCs may serve as barriers to stop oxygen diffusing to metals and interrupt the electron tunnels between the metal surfaces and the electrolyte solutions. Such environmentally friendly CILCs of POMs-based ILs are convenient for coating and removal, being vital to versatile industrial and academic applications.
Background and hypothesis: RAGE and its ligands have been implicated in pathogenesis of ischemia/reperfusion injury. We hypothesized that RAGE expression in ischemic myocardium can be imaged in mic...
Serum biomarker studies on patients with severe COVID-19 lung disease indicate that increased ligands for Receptor for Advanced Glycation End-products (RAGE) and diabetes are risk factors for severe acute respiratory distress syndrome (ARDS).
We report the preparation of honeycomb structures (HCSs) by the breath figure method with high contents of fullerene C60 (>60 wt %) with a series of monosubstituted C60 derivatives (fulleromonodendrons) terminated with oligo-poly(ethylene oxide) (o-PEO) chains. It was found that a fulleromonodendron with two terminal o-PEO chains substituted at the 2,4-position of the benzene ring is the best candidate for the preparation of HCSs. The C60-based HCSs have hierarchically organized pores locating both on the film surface and inside the film. After blending with branched or linear polystyrene, the surface morphology and the internal structure of the film were further optimized. In addition, new functions such as photoluminescence have been introduced to the film. On the basis of the investigation of the aggregation behavior of the fulleromonodendron in CHCl3 as well as the exploration of the molecular organization and optical and electrochemical properties of the HCSs, the mechanism behind the film formation has been deduced. These hierarchically organized porous films with unprecedentedly high content of fullerene C60 may find applications in sensors, catalysis, and template synthesis of functional materials.
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