Sayyed Alireza Talaei

Kashan University of Medical Sciences

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Mahmoud Salami

Kashan University of Medical Sciences

Mojgan Mohammadifar

Kashan University of Medical Sciences

Fatemeh Aghighi

Kashan University of Medical Sciences

Mohsen Taghizadeh

Kashan University of Medical Sciences

Omid Reza Tamtaji

Tehran University of Medical Sciences

Saeideh Davari

Kashan University of Medical Sciences

Mohammad Shabani

Kerman University of Medical Sciences

Abolfazl Azami

Kashan University of Medical Sciences

Gholamali Hamidi

Kashan University of Medical Sciences

Hamed Mirzaei

Kashan University of Medical Sciences

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Kashan University of Medical Sciences

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Tehran University of Medical Sciences

Isfahan University of Medical Sciences

Shahid Beheshti University of Medical Sciences

Iran University of Medical Sciences

Mashhad University of Medical Sciences

University of Tehran

University of Kashan

Shiraz University of Medical Sciences

Islamic Azad University, Tehran

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Analgesic Effect of Alcoholic Extract of Morus alba L. Leaf on Male Rats

Quarterly of Horizon of Medical Sciences (2016)

Mojgan Mohammadifar Omid Reza Tamtaji Mohammad Behnam Mohsen Taghizadeh Sayyed Alireza Talaei

Aims: As effective herbal materials, flavonoids and the phenolic compounds are with anti-pain and anti-inflammatory effects.Based on the studies, there is a huge amount of polyphenols and flavonoids in the leaves of Morus alba L. Therefore, the aim of this study was to investigate the anti-pain effects of alcoholic extract of the leaves of Morus alba L. on the rats.Materials & Methods: In the experimental study, 32 male Wistar rats were divided into 4 groups including control group and groups receiving 100, 200, and 400mg/kg alcoholic extract of the leaves of Morus alba L. There was 4week daily extract gavage.The anti-pain effect of the extract was investigated through thermal hyperalgesia, writhing, tail flick, and formalin tests.Data was analyzed by SPSS 16 software using one-way ANOVA and Tukey's post-hoc tests.Findings: Daily use of 100, 200, and 400mg/kg of alcoholic extract of the leaves of Morus alba L. for 4 weeks led to significant increases in the mean foot withdrawal latency (p<0.001) and mean tail withdrawal latency (p<0.001) and significant reductions in the percentage of abdominal constriction (p<0.001) and pain feeling in both acute (p<0.05) and chronic (p<0.01)phases of formalin test than control group.Nevertheless, the effect of 200mg/kg dose was higher than the other doses.Conclusion: Oral consumption of the alcoholic extract of the leaves of Morus alba L. leads to a reduction in pain feeling in the rats.In addition, the anti-pain effect of 200mg/kg dose is higher than other doses.

Hot plate test

10.18869/acadpub.hms.22.2.151

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Citations (1)

Morphine Consumption During Lactation Impairs Short-Term Neuronal Plasticity in Rat Offspring CA1 Neurons

Caspian Journal of Neurological Sciences (2022)

Fatemeh Aghighi Mohammad Shabani Sayyed Alireza Talaei

Background: Facing environmental factors during early postnatal life, directly or indirectly via mother-infant relationships, profoundly affects the structure and function of the mammals’ Central Nervous System (CNS). Objectives: This study aimed to evaluate the effect of morphine consumption during the lactation period on short-term synaptic plasticity of the hippocampal Cornu Ammonis 1 (CA1) neurons in rat offspring. Materials & Methods: In addition to a group of control mother rats (CO), three groups subcutaneously received 5 (M5), 10 (M10), or 20 (M20) mg/kg morphine every 12 hours during the lactation period. At 45 days old, following the stimulation of the Schaffers’ collaterals, basic field Excitatory Post-Synaptic Potentials (fEPSPs) were recorded in their offspring’s hippocampal CA1 neuronal circuits. After the construction input/output curve, paired-pulse stimulations with the inter-stimulus intervals of 20, 80, and 200 ms were applied to determine the short-term synaptic plasticity, and the paired-pulse ratio was evaluated. Results: The baseline synaptic responses of the rats CA1 neurons whose mothers received 10 and 20 mg/kg morphine twice daily during the lactation period decreased compared to the CO animals (P<0.01 & P<0.001, respectively). Furthermore, compared to the controls, the Paired-Pulse Ratio (PPR) of the CA1 neural circuits of M10 and M20 rats at 20 and 80 ms Inter-Stimulus Intervals (ISI) decreased (P<0.01). Conclusion: Morphine exposure during the lactation period has a detrimental impact on the primary synaptic activity and short-term synaptic plasticity of the hippocampal CA1 neuronal circuits of rats’ offspring.

Stimulus (psychology)

10.32598/cjns.8.29.3

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The Wound Healing Effects of Herbal Cream Containing Oliveria Decumbens and Pelargonium Graveolens Essential Oils in Diabetic Foot Ulcer Model.

PubMed (2018)

Mohaddese Mahboubi Mohsen Taghizadeh Tahereh Khamechian Omid Reza Tamtaji R. Mokhtari

The number of diabetic patients in adult population is increasing. All this population are at risk of developing diabetic foot ulcers (DFUs) that are associated with unwanted ailments and high mortality. In spite of current therapies for DFUs, further therapies are needed to help the patients.The efficacy of herbal cream containing Pelargonium graveolens and Oliveria decombens essential oils was evaluated topically for treatment of DFUs in rat animal model in comparison with two other herbal formulas containing each essential oil alone, placebo (the basic formula without active ingredients) and normal saline as control groups. After anesthesia of diabetic rats (n=75) induced by streptozotocin (STZ), diabetic wounds were visible on the hind dorsal surface of the foot. The treatments were initiated on Day 1 and repeated 3 times a day for thirteen consecutive days. On day 1, 3, 5, 8 and 13, the wound sizes were determined and assessed histologically.Three herbal formulations reduced the size of wounds in rats with DFUs, while the cream containing combined herbals of O. decumbens and P. graveolens essential oils had the highest tissue repair in DFU rat models.Due to better wound healing effects of combined herbal cream containing O. decumbens and P. graveolens essential oils, it can be recommended in treatment of DFUs.

Diabetic foot ulcer

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Culture and Antibiogram of Aerobic Bacteria Cousing Chronic Otitis Media in Zanjan

N Amir Mozafari Sayyed Alireza Talaei Amir Moghadami Hamid Reza

Antibiogram

Aerobic bacteria

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Retinoic acid and/or progesterone differentiate mouse induced pluripotent stem cells into male germ cells in vitro

Journal of Cellular Biochemistry (2019)

Javad Amini Mahabadi Abolfazl Aazami Tameh Sayyed Alireza Talaei Mohammad Karimian Tahereh Rahiminia

Abstract Numerous reagents were employed for differentiating induced pluripotent stem cells (iPSCs) into male germ cells; however, the induction procedure was ineffective. The aim of this study was to improve the in vitro differentiation of mice iPSCs (miPSCs) into male germ cells with retinoic acid (RA) and progesterone (P). miPSCs were differentiated to embryoid bodies (EBs) in suspension with RA with or without progesterone for 0, 4, and 7 days. Then, the expression of certain genes at different stages of male germ cell development including Ddx4 (pre meiosis), Stra8 (meiosis), AKAP3 (post meiosis), and Mvh protein was examined in RNA and/or protein levels by real‐time polymerase chain reaction or flow cytometry, respectively. The Stra8 gene expression increased in the RA groups on all days. But, expression of this gene declined in RA + P groups. In addition, an increased expression of Ddx4 gene was observed on day 0 in the P group. Also, a significant upregulation was observed in the expression of AKAP3 gene in the RA + P group on days 0 and 4. However, gene expression decreased in P and RA groups on day 7. The expression of Mvh protein significantly increased in the RA group on day 7. The Mvh expression was also enhanced in the P group on day 4, but it decreased on day 7, while this protein upregulated on day 0 and 7 in the RA + P group. The miPSCs have the capacity for in vitro differentiation into male germ cells by RA and/or progesterone. However, the effects of these inducers depend on the type of combination and an effective time.

Embryoid body

10.1002/jcb.29439

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Prenatal urban traffic noise exposure impairs spatial learning and memory and reduces glucocorticoid receptor expression in the hippocampus of male rat offspring

Physiology International (2020)

Fatemeh Sadat Sajjadi Fatemeh Aghighi Zeinab Vahidinia Abolfazl Azami-Tameh Mahmoud Salami

Exposure to noise stress during early life may permanently affect the structure and function of the central nervous system. The aim of this study was to evaluate the effects of prenatal exposure to urban traffic noise on the spatial learning and memory of the rats' offspring and the expression of glucocorticoid receptors (GRs) in their hippocampi.Three g\roups of pregnant rats were exposed to recorded urban traffic noise for 1, 2 or 4 h/day during the last week of pregnancy. At the age of 45 days, their male offspring were introduced to the Morris water maze (MWM) for assessment of spatial learning and memory. The corticosterone levels were measured in the offspring's sera by radioimmunoassay, and the relative expression of glucocorticoid and mineralocorticoid receptors (MRs) in their hippocampi was evaluated via RT-PCR.Facing urban traffic noise for 2 and 4 h/day during the third trimester of pregnancy caused the offspring to spend more time and to travel a larger distance than the controls to find the target platform. Analogously, these two groups were inferior to their control counterparts in the probe test. Also, prenatal noise stress elevated the corticosterone concentration in the sera of the rats' offspring and dose-dependently decreased the relative expression of the mRNA of both GRs and MRs in their hippocampi.Urban traffic noise exposure during the last trimester of pregnancy impairs spatial learning and memory of rat offspring and reduces GRs and MRs gene expression in the hippocampus.

Corticosterone

Prenatal Stress

Water maze

10.1556/2060.2020.00022

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Citations (6)

Role of non-coding RNAs in neuroblastoma

Cancer Gene Therapy (2023)

Ali Arash Anoushirvani Arezoo Jafarian Yazdi Sanaz Amirabadi Sahar Ahmadi Asouri Rana Shafabakhsh

MEG3

10.1038/s41417-023-00623-0

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