Yabei Liu

University of Science and Technology of China

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Pingsheng Fan

University of Science and Technology of China

Gaofei Fan

University of Science and Technology of China

Kelong Ma

Anhui University of Traditional Chinese Medicine

Tengyue Zhang

Zhejiang Sci-Tech University

Tengyue Zhang

Anhui Provincial Hospital

Qiaohong Duan

First Affiliated Hospital of Sichuan Medical University

Chengtao Weng

University of Science and Technology of China

Jin Huang

Changzhou No.2 People's Hospital

Zhao‐Shen Li

Changhai Hospital

Weidong Jia

Anhui Provincial Hospital

Cooperative Institutions

University of Science and Technology of China

Anhui Medical University

Anhui Provincial Hospital

Chinese Academy of Sciences

Sichuan University

Tianjin Medical University

Shanghai Jiao Tong University

Tianjin University of Traditional Chinese Medicine

Chinese Academy of Medical Sciences & Peking Union Medical College

Huazhong University of Science and Technology

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Verapamil enhances the sensitivity of oxaliplatin to tumor cells by influencing the PARP pathway.

PubMed (2019)

Tengyue Zhang Guangshan Yang Yabei Liu Pingsheng Fan

PARP is a DNA damage-modifying enzyme present in most eukaryotic cells. In this study, reverse docking showed that verapamil (Vera), which can effectively bind PARP1/2, could significantly inhibit PARP1/2 activity inside and outside the system. Moreover, it could enhance the sensitivity of oxaliplatin to low-expression P-glycoprotein (P-gP) tumor cells and strengthen its apoptosis-inducing effect on tumor cells under the reverse drug resistance concentration of tumor cells. Vera, which can reverse chemotherapy resistance of tumor cells, showed no simple correlations with oxaliplatin drug resistance or P-gP expression and could enhance the anti-tumor effect of platinum chemotherapeutic agents by influencing the PARP pathway.

PARP1

10.1691/ph.2019.9715

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Citations (1)

Evaluation of clinical efficacy after combinational treatment of esophageal cancer using target artery perfusion of verapamil and chemotherapy

Translational Cancer Research (2017)

Yabei Liu Liting Qian Kelong Ma Tengyue Zhang Gaofei Fan

Background: This study aimed to investigate the clinical efficacy of target artery perfusion of verapamil combined with chemotherapy in treating esophageal cancer (EC). Methods: A total of 46 patients with EC (stage III and IV) were treated with verapamil combined with chemotherapy via target artery infusion. Two to four courses per month of the treatment were administrated. Imaging modalities used in staging EC before and after treatment include gastroscopy/endoscopic ultrasonography, computed tomography (CT) combined with 64-detector-row gemstone spectral imaging/3.0-T magnetic resonance imaging (MRI). The clinical beneficial rate and survival time were also evaluated. Results: Out of 46 patients, 2 cases achieved complete remission (CR) and 39 cases achieved partial remission (PR). There were 3 cases had no change and 2 cases with progressive disease. The overall effective rate (CR + PR) was 89.13%. After treatment, dysphagia in 42 patients was significantly improved except 5 cases with narrow type. A total of 11 cases with hoarseness caused by recurrent laryngeal nerve paralysis before therapy recovered normal voice and another 7 cases were completely relieved. Forty-five patients were treated with 1 course of radiotherapy, and 1 patient was treated by operation after 2 to 4 courses of treatment and clinical tumor stage had decreased. A total of 42 patients (91.30%) survived for more than a year, 24 patients (52.17%) survived for more than 2 years, and 12 patients (26.09%) survived for more than 3 years. Patients also achieved better Karnofsky performance status (KPS) scores, body weight, and positive clinical benefit of the dosage of analgesics, which were 91.30% (42/46), 52.17% (24/46), and 66.67% (4/6), respectively. No significant complication was observed before and after verapamil. Conclusions: Target artery infusion of verapamil combined with chemotherapy drug significantly reduced the clinical tumor stage of advanced EC (≥ stages III), improved the quality of life, and prolonged the survival time. And patients regained the opportunity of radical radiotherapy or surgery when the clinical tumor stages were decreased.

10.21037/17767

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Citations (2)

CDKN2B is critical for verapamil-mediated reversal of doxorubicin resistance in hepatocellular carcinoma

Oncotarget (2017)

Tengyue Zhang Kelong Ma Jin Huang Wang Shi-tang Yabei Liu

// Tengyue Zhang 1, 2, * , Kelong Ma 3, * , Jin Huang 2, * , Shitang Wang 4, * , Yabei Liu 2 , Gaofei Fan 2 , Miao Liu 2 , Guangshan Yang 2 , Cheng Wang 4 and Pingsheng Fan 1, 2 1 School of Clinical Medicine, Shan Dong University, Jinan 250100, China 2 The Cancer Hospital of Anhui Province, Provincial Hospital of Anhui Medical University, Hefei 230032, China 3 Clinical College of Integrated Traditional Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei 230032, China 4 Department of General Surgery, Provincial Hospital of Anhui Medical University, Hefei 230032, China * These authors have contributed equally to this work Correspondence to: Pingsheng Fan, email: wangal2014@sohu.com Cheng Wang, email: blackpippy@163.com Keywords: hepatocellular carcinoma (HCC); verapamil (VER); doxorubicin (ADM); CDKN2B; chemotherapy resistance Received: June 14, 2017 Accepted: October 05, 2017 Published: October 26, 2017 ABSTRACT In this study, we explored the function and mechanism of CDKN2B genes in verapamil (VER)-induced reversal of resistance to doxorubicin (ADM) chemotherapy in hepatocellular carcinoma (HCC). We examined 4 HCC cell lines and found that the expression levels of CDKN2B genes correlated with the level of apoptosis induced by ADM+VER. Overexpression of CDKN2B genes promoted apoptosis in cells treated with VER+ADM. CDKN2B knockdown using siRNA weakened the effect of ADM+VER, indicating that ADM+VER promotes HCC cell apoptosis and that CDKN2B genes participate in VER-mediated promotion in tumor cell apoptosis. Future research will further explore the functional mechanism, and the associated signal transduction pathways via which CDKN2B affects HCC drug resistance.

CDKN2B

10.18632/oncotarget.22123

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Citations (11)

The relationship among resilience, general self-efficacy and coping styles in patients with tibia and fibula fracture

The Journal of practical nursing (2016)

Wenjing Zhang Yan Wang Yabei Liu

Objective To explore the relationship among resilience, general self-efficacy and coping styles of inpatients with tibia and fibula fracture. Methods Totally 104 inpatients with tibia and fibula fracture who met the conditions were investigated with General Self-Efficacy Scale, Connor-Davidson Resilience Scale and Medical Coping Modes Questionnaire. Results The total score of resilience with tibia and fibula fracture inpatient was 52.36±9.56, which had a positive relationship with general self-efficacy and self-improvement coping style. Educational level, general self-efficacy, facing coping and yielding coping styles were influencing factors of resilience in patients with tibia and fibula fracture. Conclusions The level of resilience in patients with tibia and fibula fracture needs to be improved. Health care workers should pay attention to improve patient's general self-efficacy, focus on patient's coping styles and strengthen psychological health education of lower degree patients. Key words: Resilience, psychological; Tibia and fibula fracture; Self-efficacy; Coping style

Self-Efficacy

10.3760/cma.j.issn.1672-7088.2016.14.015

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Citations (0)

Clinical evaluation of targeted arterial perfusion of verapamil and chemotherapeutic drugs in interventional therapy of advanced lung cancer

Cancer Chemotherapy and Pharmacology (2013)

Jin Huang Tengyue Zhang Kelong Ma Pingsheng Fan Yabei Liu

To assess the clinical efficacy of targeted arterial perfusion of verapamil and chemotherapeutic agents in the interventional therapy of lung cancer.Forty patients with advanced lung cancer underwent treatment with targeted arterial perfusion of verapamil and chemotherapeutic agents using Seldinger technique. Interventional therapy was performed once a month, and each subject received interventional treatment for 2 or more cycles. The therapeutic efficacy was evaluated 2 months post-treatment.Out of 40 patients with advanced lung cancer, 5 cases achieved complete remission (CR) and 29 cases achieved partial remission (PR), with a total effectiveness (CR + PR) rate of 85 %. Besides, 32 cases achieved significantly alleviated clinical symptoms, and 29 cases had decreased clinical tumor stage. All subjects had stable karnofsky performance status score and body weight. Among the 40 patients, 13 cases had leucopenia, 10 cases had gastrointestinal reactions, 3 cases presented with elevated alanine aminotransferase/aspartate aminotransferase ratio, and 3 cases had fever. However, all these side effects relieved quickly. No elevation of BUN/Cr ratio and allergic reactions was observed. No significant changes in cardiac function and electrocardiogram were noticed after the treatment.Targeted arterial perfusion of verapamil and chemotherapeutic drugs can improve the clinical symptoms of patients with advanced lung cancer and increase the efficacy of chemotherapeutic agents, thereby providing an opportunity for radiotherapy or surgical treatment for advanced lung cancer.

Arterial perfusion

10.1007/s00280-013-2271-1

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Citations (17)

Chemical modification of cotton cellulose in supercritical carbon dioxide: Synthesis and characterization of cellulose carbamate

Carbohydrate Polymers (2006)

Cuiyu Yin Jianbo Li Qun Xu Qi Peng Yabei Liu

Supercritical Carbon Dioxide

Thermogravimetry

Carbamate

Chemical modification

10.1016/j.carbpol.2006.05.010

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Citations (149)

Treatment of malignant ascites with a combination of chemotherapy drugs and intraperitoneal perfusion of verapamil

Cancer Chemotherapy and Pharmacology (2013)

Weidong Jia Zhiqiang Zhu Tengyue Zhang Gaofei Fan Pingsheng Fan

Intraperitoneal Chemotherapy

10.1007/s00280-013-2158-1

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Citations (9)

Studies on assessment methods of malignant ascites residue and changes of verapamil concentration in intraperitoneal perfusion chemotherapy

Cancer Chemotherapy and Pharmacology (2014)

Chengtao Wen Qiaohong Duan Tengyue Zhang Yabei Liu Yang Wu

10.1007/s00280-014-2532-7

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Citations (0)

Evaluation of clinical efficacy after combinational treatment of esophageal cancer using target artery perfusion of verapamil and chemotherapy

Translational Cancer Research (2017)

Yabei Liu Liting Qian Kelong Ma Tengyue Zhang Gaofei Fan

Background: This study aimed to investigate the clinical efficacy of target artery perfusion of verapamil combined with chemotherapy in treating esophageal cancer (EC).Methods: A total of 46 patients with EC (stage III and IV) were treated with verapamil combined with chemotherapy via target artery infusion. Two to four courses per month of the treatment were administrated. Imaging modalities used in staging EC before and after treatment include gastroscopy/endoscopic ultrasonography, computed tomography (CT) combined with 64-detector-row gemstone spectral imaging/3.0-T magnetic resonance imaging (MRI). The clinical beneficial rate and survival time were also evaluated.Results: Out of 46 patients, 2 cases achieved complete remission (CR) and 39 cases achieved partial remission (PR). There were 3 cases had no change and 2 cases with progressive disease. The overall effective rate (CR + PR) was 89.13%. After treatment, dysphagia in 42 patients was significantly improved except 5 cases with narrow type. A total of 11 cases with hoarseness caused by recurrent laryngeal nerve paralysis before therapy recovered normal voice and another 7 cases were completely relieved. Forty-five patients were treated with 1 course of radiotherapy, and 1 patient was treated by operation after 2 to 4 courses of treatment and clinical tumor stage had decreased. A total of 42 patients (91.30%) survived for more than a year, 24 patients (52.17%) survived for more than 2 years, and 12 patients (26.09%) survived for more than 3 years. Patients also achieved better Karnofsky performance status (KPS) scores, body weight, and positive clinical benefit of the dosage of analgesics, which were 91.30% (42/46), 52.17% (24/46), and 66.67% (4/6), respectively. No significant complication was observed before and after verapamil.Conclusions: Target artery infusion of verapamil combined with chemotherapy drug significantly reduced the clinical tumor stage of advanced EC (≥ stages III), improved the quality of life, and prolonged the survival time. And patients regained the opportunity of radical radiotherapy or surgery when the clinical tumor stages were decreased.

10.21037/tcr.2017.11.01

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Citations (4)

Famotidine promotes inflammation by triggering cell pyroptosis in gastric cancer cells

BMC Pharmacology and Toxicology (2021)

Jin Huang Pingsheng Fan Miao Liu Chengtao Weng Gaofei Fan

Abstract Background Cell pyroptosis has been characterized by cell swelling and pro-inflammatory factors release to aggravate inflammatory reaction., such as interlukin-1 beta (IL-1β) and interlukin18 (IL-18). However, the function of famotidine, an antagonist of histamine H2-receptor antagonists, in cell pyroptosis remained unknown. Methods Real-time quantitative PCR (qPCR), western blotting (WB), LDH release assay and enzyme linked immunosorbent assay (Elisa) combined with inhibitor were performed to analyze the effect of famotidine on cell pyroptosis-related gene expression. Results In this study, we found that famotidine (300 μm) treatment led to a phenomenon of cell pyroptosis as confirmed by LDH assay. Further results showed that famotidine triggered cell pyroptosis in gastric cancer cells by activation of NLPR3 inflammasomes including ASC, Caspase-1 and NLRP, leading to enhanced IL-18, not IL-1β, mature and secretion. What’s more, the results also showed GSDME, not GSDMD, was increased in response to famotidine stimulation in BGC823 and AGS cells. Mechanically, phosphorylation of ERK1/2 was drastically enhanced in present with famotidine treatment, while inhibition of ERK1/2 activity by U0126 could reverse the promotion of famotidine in IL-18 secretion. Conclusion These findings revealed a novel role of famotidine in cell pyroptosis in patients with gastric cancer, a comprehensive consideration is needed in treatment of gastric cancer.

Pyroptosis

Famotidine

Viability assay

10.1186/s40360-021-00533-7

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Citations (17)