НТ

Н. Т. Райхлин

Ministry of Health of the Russian Federation

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ЕА

Е. А. Смирнова

Lomonosov Moscow State University

I. M. Shnaidman

Russian Academy of Sciences

D. Katenkamp

Jena University Hospital

АГ

А. Г. Перевощиков

Ministry of Health of the Russian Federation

Wim Quint

DDL Diagnostic Laboratory

Igor Buchwalow

Institut für Hämatopathologie Hamburg

S. V. Petrov

Kazan State Medical University

Johan C. Kuijpers

Reinier de Graaf Hospital

I. A. Bukaeva

Ministry of Health of the Russian Federation

Frank Smedts

Cork University Hospital

Cooperative Institutions

Russian Academy of Sciences

Academy of Medical Sciences

Columbia University

Ministry of Health of the Russian Federation

Russian Cancer Research Center NN Blokhin

Harvard University

Cancer Research Center

United States Department of Veterans Affairs

Karolinska Institutet

Albert Einstein College of Medicine

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Gastrointestinal melatonin: cellular identification and biological role.

PubMed (2002)

I. М. Kvetnoy И. Э. Ингель T. V. Kvetnaia Nadezhda K Malinovskaya С. И. Рапопорт

Melatonin, a pineal hormone, because of its wide activity spectrum, is a subject of much current interest for biologists and physicians. It has been demonstrated that pineal gland is not an exclusive source of melatonin synthesis. Melatonin synthesis has been found in different sites of the organism, and a major source of extrapineal melatonin is the gastrointestinal tract. The role of melatonin in gastrointestinal functions is considered in the present review.

Pinealocyte

Identification

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Citations (56)

Apoptosis-inducing and apoptosis-preventing functions of poliovirus

Journal of Virology (1995)

Elena A. Tolskaya Lyudmila I. Romanova Marina S. Kolesnikova T A Ivannikova Е. А. Смирнова

Data showing that an apoptotic reaction (the exit into the cytoplasm and nucleolytic internucleosomal degradation of chromosomal DNA, compaction and fragmentation of chromatin, cellular shrinkage, and cytoplasmic blebbing) developed in a subline of HeLa-S3 cells upon nonpermissive poliovirus infection with either a guanidine-sensitive poliovirus in the presence of guanidine, a guanidine-dependent mutant in the absence of guanidine, or certain temperature-sensitive mutants at a restrictive temperature are presented. Essentially, no apoptotic reaction occurred upon permissive infection of these cells. Both permissive and nonpermissive infections resulted in the inhibition of host protein synthesis. Actinomycin D or cycloheximide also elicited a rapid apoptotic reaction in uninfected cells. However, preinfection or coinfection with poliovirus prevented the apoptotic response to the addition of actinomycin D, and preinfection blocked cycloheximide-induced apoptosis as well. These data fit a model in which the cells used are prepared to develop apoptosis, with their viability due to the presence of certain short-lived mRNA and protein species. Poliovirus infection turns on two oppositely directed sets of reactions. On the one hand, the balance is driven toward apoptosis, probably via the shutoff of host macromolecular synthesis. On the other hand, viral protein exhibits antiapoptotic activity, thereby preventing premature cell death. To our knowledge, this is the first description of an antiapoptotic function for an RNA virus.

HeLa

Fragmentation

Guanidine

10.1128/jvi.69.2.1181-1189.1995

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Citations (198)

Histochemical investigation of oxidoreductases in experimental silicosis

Bulletin of Experimental Biology and Medicine (1965)

Н. Т. Райхлин I. M. Shnaidman

Silicosis

10.1007/bf00793266

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Ultrastructural changes in the cells of antral gastric mucosa in patients with duodenal ulcer on melatonin treatment

DOAJ (DOAJ: Directory of Open Access Journals) (2003)

С. И. Рапопорт С. И. Рапопорт Н. Т. Райхлин Н. Т. Райхлин Nadezhda K Malinovskaya

Aim. To study ultrastructural condition of the eels in antral gastric mucosa in patients with duodenal ulcer on melatonin treatment. Material and methods. Electron microscopy was made of biopsy specimens of antral stomach mucosa obtained from 14 patients with duodenal ulcer (DU) in exacerbation and in clinicoendoscopic remission after therapy with proton pump blockers (group I) and after this therapy combined mth melatonin (group 2). Results. In patients of group 2 there was an increased number of differentiated cover and principal cells, moderately differentiated parietal cells predominated. Conclusion. Melatonin is one of the drugs potentiating trophic processes in gastric mucosa.

Gastric antrum

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[Biogenic monoamines in thyroid gland Askanazy (Hürthle) cells].

PubMed (1971)

N. A. Kraevskii Н. Т. Райхлин I. G. Mikhaǐlov

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[Localized fibrous mesothelioma of the pleura. Morphological studies of 7 cases].

PubMed (1987)

D. Katenkamp А. Г. Перевощиков H Kosmehl Lutz Langbein Н. Т. Райхлин

Localized tumors of pleura should clearly be separated from diffuse pleural mesotheliomas due to clinical and pathological peculiarities. But there is some dispute on their proper interpretation and hence disagreement about their correct designation. Some call them "fibrous tumors (fibromas)" of pleura and appreciate by this term the fibroplastic potency of tumor cells and the lacking relation to overlying mesothelial surface cells, others prefer the name "fibrous mesothelioma" and allude to an at least abortive mesothelial differentiation within the tumor tissue. Examining 7 own tumor cases by means of light microscopic, topo- and immunohistochemical as well as electron microscopic methods the investigations were aimed at analysing the morphological structure of these tumors and subjecting it to a critical reappraisal with regard to a suited designation. Histologically, a marked variability of histological structure and texture was found, there were regions with similarities to fibromas, fibrous histiocytomas, hemangiopericytomas and nerve sheath tumors as well as blastema-like areas. Occasionally a vasoformative activity could be seen. In three tumors a few epithelioid cell complexes were visible, but neither keratin intermediate filaments nor UEA-I reactivity was to be demonstrated by immunohistochemistry. Antibodies against factor VIII associated antigen only marked endothelial cells of vascular structures. By the electron microscopic examination of 1 case abortive mesothelial differentiations were visualized (some lumen-like space formations, stub-like cellular projections of the cavity facing side, primitive intercellular junctions and fragmented basal lamina-like material). The findings inclusive the immunohistochemical results are discussed and jointly taken for sustaining the interpretation of these tumors as mesotheliomas and for militating against the classification as simple pleural fibromas or fibrous pleural tumors, respectively.

Mesothelium

Solitary Fibrous Tumor

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Ultrastructural criteria of malignancy of adrenal medullary tumor.

Bulletin of Experimental Biology and Medicine (2002)

Н. Т. Райхлин А. А. Баронин E. A. Smirnova Н А Пробатова М. И. Бронштейн

10.1023/a:1020616923868

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Citations (5)

Electron-microscopic autoradiography of DNA-synthesizing cells of growing smooth muscle tissue in rats