Abstract Lithocholic acid‐3α‐sulfate is metabolized by human intestinal microflora to nonpolar metabolites which have been partially purified by Sephadex LH‐20 chromatography. These metabolites were characterized by thin layer and gas liquid chromatography as well as combined gas liquid chromatography‐mass spectrometry. The chromatographic properties of one of the metabolites are consistent with those described for a Δ 2 ‐or Δ 3 . The formation of cholenates by the microflora may represent a retoxification of the sulfate ester of lithocholic acid.
Changes in composition of both total aerobes and anaerobes of rat intestinal microflora do not appear to affect the metabolism of taurolithocholic acid.
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