Shweta Singh

Dr. Hari Singh Gour University

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Saif Hameed

University of Science and Technology

Zeeshan Fatima

University of Bisha

Daniel V. Zurawski

Walter Reed Army Institute of Research

Zeeshan Fatima

Amity University

Sayan Bhattacharyya

All India Institute of Hygiene and Public Health

Crystal L. Jones

Walter Reed Army Institute of Research

Dhirendra Kumar

Chaudhary Devi Lal University

Sandeep Hans

IBM Research - India

Asim Sarfraz

All India Institute of Medical Sciences

Emil Lesho

Unity Health System

Cooperative Institutions

Amity University

University of Chicago

Walter Reed Army Institute of Research

University of Michigan–Ann Arbor

All India Institute of Medical Sciences

Uniformed Services University of the Health Sciences

Philipps University of Marburg

University of Maryland, Baltimore

Seven Bridges Genomics (United States)

Institute of Medical Sciences

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Screening plants extracts for Antifungal activity against Rhizoctonia solani

Research Journal of Pharmacy and Technology (2021)

Shweta Singh Jaiganesh Rengarajan Iyappan Sellamuthu

The adverse effect of pesticides used for controlling pests and the diseases caused by them is extensively rising. To overcome this harmful environmental impact, alternative methods are being studied and developed. Out of many possible methods, one effective method is to use plant extracts which embodies natural substances having antifungal properties. In an attempt towards enhancement of sustainable antifungal approach, four different concentrations of four plant extracts Citrus limon, Azadirachta indica, Ocimum gratissimum and Acalypha indica, were tested for their antifungal activity against Rhizoctonia solani, which is a serious threat for plants, and is responsible for considerable crop and yield losses. The aim of this study is to minimize yield losses and to regain the attention of formers towards exploiting natural resources for diseases control. From the results, it can be concluded that different concentrations of plant extracts have caused substantial inhibition in the mycelial growth of R. solani. The leaf extract of Ocimum gratissimum was highly effective in inhibiting mycelial growth, at the concentration of 500mg/ml of extract followed by Citrus limon, Azadirachta indica, and Acalypha indica. These plants might have potential for the development of natural fungicide for the management of diseases caused by fungal pathogens. Also, fungicides developed from these botanical extracts can prove to be highly effective for the management of plant diseases and would be simply obtainable, nonpolluting, biodegradable and economical.

Azadirachta

Ocimum gratissimum

10.52711/0974-360x.2021.01132

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Citronellal-induced disruption of membrane homeostasis in Candida albicans and attenuation of its virulence attributes

Revista da Sociedade Brasileira de Medicina Tropical (2016)

Shweta Singh Zeeshan Fatima Saif Hameed

There is an increasing burden of multidrug resistance. As a result, deciphering the mechanisms of action of natural compounds with antifungal activity has gained considerable prominence. We aimed to elucidate the probable mechanism of action of citronellal, a monoterpenoid found in the essential oil extracted from Cymbopogon plants, against Candida albicans.Drug susceptibility was measured by broth microdilution and spot assays. Ergosterol levels were estimated using the alcoholic potassium hydroxide method and H+ extrusion was assessed by monitoring the glucose-induced acidification of the external medium. Virulence traits were studied by hyphal morphogenesis and biofilm formation, along with fungal cell adherence to polystyrene surface and human oral epithelial cells.Citronellal showed anticandidal activity against C. albicans and non-albicans species of Candida at a minimum inhibitory concentration of 1 mg/ml. Citronellal interfered with membrane homeostasis, which is the major target of known antifungal drugs, by increasing the hypersensitivity of the fungi to membrane-perturbing agents, reducing ergosterol levels, and diminishing glucose-induced H+ extrusion. In addition, oxidative and genotoxic stresses were induced via an increased production of reactive oxygen species. Furthermore, citronellal inhibited the virulent attributes of yeast-to-hypha transition and biofilm formation. It also reduced cell adherence to polystyrene surface and the human oral epithelial cells.This is the first study to propose the cell membrane, morphogenetic switching, biofilm formation, and cell adherence of Candida albicans as potential targets for the anticandidal activity of citronellal. However, clinical investigations on the therapeutic applications of citronellal are required.

Citronellal

Ergosterol

10.1590/0037-8682-0190-2016

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Unravelling the role of DRIF transcription factors in Arabidopsis thaliana

Free Radical Biology and Medicine (2018)

Ana Maria Cunha Sara Laranjeira Shweta Singh João Raimundo Rómulo Sobral

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10.1016/j.freeradbiomed.2018.04.383

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Critical Leukostasis in Chronic Phase of CML: a Case Report

Journal of Medical and Radiation Oncology (2024)

Arihant Jain Amaravathi Uthayakumar Shweta Singh N Balamurugan

Patients with hematologic malignancies can visit the emergency department for various reasons. We report a case of a 46-year-old male recently diagnosed with chronic myeloid leukemia (CML) who presented to the emergency department with vertigo and dyspnea. Clinical examination showed low oxygen saturation, right sensorineural hearing loss, and splenomegaly. Hyperleukocytosis in complete blood count and clinical features suggestive of poor tissue perfusion made us suspect leukostasis. Initial brain and chest imaging were normal. We treated him with leukapheresis, cytoreduction, and tumor lysis syndrome (TLS) prophylaxis. Subsequent brain imaging showed signs of reperfusion injury, which reduced after one week. The symptoms improved and the patient was discharged. Leukostasis is a medical emergency, and it is essential to consider this in patients with hematologic malignancies. Early diagnosis and treatment are crucial because the mortality rate rises to 40% if left untreated.

Leukostasis

10.53011/jmro.2024.01.10

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Antimicrobial potential of Indian spices

Biotech Today (2016)

Shweta Singh Sharda Sharma Saif Hameed Zeeshan Fatima

Infectious diseases are increasing at an alarming pace. Many synthetic drugs are for the treatment of these infectious diseases. However, long term exposure of the known antimicrobial drugs has led to emergence of multidrug resistance problem. In addition, available antimicrobial drugs are expensive as well as cause side effects in humans. Hence, there is an urgency to find novel drugs and novel targets. Natural compounds have been one of the alternative promising strategies that have been widely used nowadays. Since antiquity the Indian spices have been utilized for their nutritive and medicinal values. This article at a common platform summarizes the antimicrobial potential of some of the most common and prevalent Indian spices.

10.5958/2322-0996.2016.00010.7

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A Pharmacological Review:PassifloraSpecies

Asian Journal of Pharmaceutical Research (2015)

Saurabh Tiwari Shweta Singh Shalini Tripathi Sunil Kumar

Plants have been the basis of many traditional medicines throughout the world for thousands of years and have continued to provide new remedies to mankind. They are one of the richest sources of bioactive compounds. The genus Passiflora L. comprises about 520 species of dicotyledonous plants in the family Passifloraceae. Passiflora incarnata and P. alata, also commonly known as Passion flower, are two species of a perennial climbing vine with beautiful exotic flowers and delicious fruit that grow worldwide, preferring subtropical, frost-free climates. They are native to the tropical and semi-tropical United States (Virginia to Florida and as far west as Texas), Mexico, Central American, and from Brazil to Paraguay through northern Argentina. It is used extensively for treatment of some diseases like as anxiety, insomnia, convulsion, sexual dysfunction, cough and cancer. Passionflower is currently official in the national pharmacopeias of Egypt, France, Germany and Switzerland, and also mongraphed in the British Herbal Pharmacopoeia and the British Herbal Compendium, the ESCOP monographs, the Commission E, the German Standard Licenses, the German Homeopathic Pharmacopoeia, and the Homeopathic Pharmacopoeia of the United States. The present article including the detailed exploration of pharmacological properties of P. incarnata is an attempt to provide a direction for further research.

Pharmacopoeia

Herbarium

Ethnobotany

Vine

10.5958/2231-5691.2015.00030.1

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The phytochemistry and pharmacological activity ofTerminalia arjuna(Roxb) Wight & Arn

Medicinal Plants - International Journal of Phytomedicines and Related Industries (2013)

Shweta Singh Lalit Sharma Suresh Kumar Sharma S. K. Tewari

Terminalia arjuna (Roxb) Wight & Arn is a medicinally important tree species of the family Combretaceae. It is used in Indian medicine system due to its high potential for several ailments. Various parts of T. arjuna have been investigated for the presence of phyto-constituents and pharmacological activities. Triterpenoids are mainly responsible for cardiovascular properties while flavonoids, tannins, terpenoids and glycosides are responsible for its anti-oxidant, anti-diabetic, anti-fungal, anti-microbial, anti-mutagenic, anti-diarrhoeal, anti-leishmanial, hypotensive, hypolipidemic, gastroprotective and hepatoprotective properties. Several important phytoconstituents have been isolated from different extracts of T. arjuna. The review aims to compile and analyse the information on phytochemical and pharmacological activities of T. arjuna.

Wight

Phytochemistry

10.5958/j.0975-6892.5.3.017

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Antimicrobial Agents in Agriculture and Their Implications in Antimicrobial Resistance

Springer eBooks (2022)

Shweta Singh Arun Goyal

10.1007/978-3-030-84126-3_3

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Evaluation of Antioxidant Activity of Physalis Minima

Chemical Science Transactions (2014)

Shweta Singh Poonam Prakash

The present study aimed at evaluating the in vitro study of antioxidant activity of crude extracts (methanol, acetone, ethyl acetate and chloroform) of stem and leaves of physalis minima.The antioxidant activity was determined by two methods DPPH (1, 1-diphenyl-2-picryl hydroxyl) assay and reducing power assay.The DPPH free radical scavenging activity of stem and leaves of physalis minima was determined at different concentration (200 µg, 400 µg, 600 µg and 800 µg).The entire tested sample showed lower scavenging activity than standard.The scavenging effect and reducing power of the eight extracts of the leaf and stem decreased in order of Methanol leaf extract > Methanol stem extract > Acetone leaf extract > Ethyl acetate leaf extract > Acetone stem extract > Ethyl acetate stem extract > Chloroform leaf extract > Chloroform stem extract.Thus result clearly indicated that the methanolic extract of leaf of P.minima showed higher activity compared to other extracts of stem and leaves.Hence is effective in scavenging free radical and has the potential to be a powerful antioxidant.

Physalis

Maxima and minima

10.7598/cst2014.800

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Predisposing factors endorsing Candida infections.

PubMed (2015)

Shweta Singh Zeeshan Fatima Saif Hameed

Candida albicans is an opportunistic human fungal pathogen which is involved in infections ranging from superficial, mucosal to systemic candidiasis. It is the fourth most leading cause of death in nosocomial infections. Candidal infections are increasing at an alarming rate due to poor clinical management in hospital settings, more use of antibiotics, increased drug resistance, immunosuppression and host-pathogen related factors. There are various predisposing factors which can be immunologic or non-immunologic in origin that make a person susceptible to such infections. This review article establishes the need to understand the various predisposing factors leading to Candidal infections and discusses them on a common platform.

Immunosuppression

Fungal pathogen

Candida infections

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Citations (43)