Roger M. Arce

The University of Texas Health Science Center at Houston

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Adolfo Contreras

Universidad del Valle

Adriana Jaramillo

Institución Universitaria Colegios de Colombia

Christopher W. Cutler

Augusta University

Javier Enrique Botero

Universidad de Antioquia

Jorge H Ramírez

University of Michigan–Ann Arbor

Mohamed M. Meghil

Augusta University

Mahmoud Elashiry

Augusta University

Lina J. Suárez

Universidad Nacional de Colombia

Julián A. Herrera

Universidad del Valle

Beatriz Parra

Universidad del Valle

Cooperative Institutions

Augusta University

Georgia Regents Medical Center

Augusta University Health

University of North Carolina at Chapel Hill

Universidad del Valle

Universidad Nacional de Colombia

British Society of Periodontology

Universidade de São Paulo

Guarulhos University

National Cancer Center of Georgia

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Toothbrush contamination in family members

Revista clínica de periodoncia implantología y rehabilitación oral (2010)

Adolfo Contreras Roger M. Arce Javier Enrique Botero Adriana Jaramillo Marisol Betancourt-Quiroz

Objective:The purpose of this study was to determine the bacterial contamination of toothbrushes in family members.Materials and Methods: One hundred and two healthy subjects were included in this descriptive study.Every individual was examined clinically and microbiologically using the CPITN index and collecting subgingival plaque samples.Each participant received a toothbrush for home use and after one month they returned it to the investigators.All toothbrushes were cultured to determine the presence of periodontopathic bacteria and enteric rods.Wilkoxon signed rank test and t student test (P ≤0.05) were used to compare differences in the subgingival microbiota and toothbrush contamination and CPITN index among family members.Results: A high proportion of toothbrushes resulted highly contaminated with enteric rods (P ≤0.001) compared to the subgingival environment where periodontopathic bacteria were more prevalent.The most frequent microorganisms found in toothbrushes used by parents and children for one month were Enterobacteriaceae, Pseudomonadaceae species (>50%) and Fusobacterium spp (30%).Conclusions: High levels of enteric rods were commonly detected in toothbrushes used for 1 month among members of the families.These opportunistic organisms may have an important role in oral infections including gingivitis and periodontitis.Monthly replacement or disinfection of the toothbrush can reduce the risk of bacterial transmission/translocation and thus diminish the incidence of biofilm associated oral diseases.

10.4067/s0719-01072010000100004

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Citations (3)

Surgical Periodontal Management of Peripheral Ossifying Fibroma: A Series of Three Cases

Case Reports in Dentistry (2024)

Karo Parsegian Roger M. Arce Nikola Angelov

Peripheral ossifying fibroma (POF) is a benign swelling of the gingival connective tissue commonly associated with dental biofilm and biofilm-retentive dental appliances. In the present case report, we described three cases of POF with different clinical presentations and treatment approaches. The treatment consisted of the removal of supra- and subgingival calculus, followed by a flap surgery with excision of the entire lesion ensuring the inclusion of the periosteal bed. The first patient developed POF during her pregnancy that remained clinically noticeable postpartum. The second case represented a rare case of POF appearing on the palatal aspect of the anterior maxilla of an African American male. The third case represented POF that developed on the mandible, and contrary to the first two cases, it was excised using a diode laser and not a scalpel blade. All patients showed uneventful healing during follow-up appointments; however, poor patient compliance did not allow for evaluation of long-term healing responses and possible recurrence of the lesion. Within the limitations of this clinical report, it is evident that the periodontal surgical approach was effective in managing POF with stable short-term clinical outcomes.

Mandible (arthropod mouthpart)

Fibroma

10.1155/2024/3683561

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Citations (0)

Unpublished periodontal studies - completed before Oct 2013 - & no results available at ClinicalTrials.gov = 74.5% (227 / 306).

Figshare (2014)

Jorge H Ramírez Adolfo Contreras Andrés Cruz Roger M. Arce

Only 15% (46 / 308) of periodontal disease ClinicalTrials.gov study records - completed before Oct 2013 - have been published by a peer-review biomedical journal. ---------- Only 12% (36 / 308) of these studies have results available at ClinicalTrials.gov - 3 published - 33 unpublished ---------- Unpublished periodontal disease studies - completed before October 2013 - without results availalble at ClinicalTrials.gov = 74.5% (227 /306). `ñ

10.6084/m9.figshare.1211174

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Systemic Th17 response in the presence of periodontal inflammation

Journal of Applied Oral Science (2020)

Lina J. Suárez Daniel E. Vargas Adriana Rodríguez Ciódaro Roger M. Arce Nelly S. Roa

The relationship between periodontitis and the pathogenesis of other inflammatory diseases, such as diabetes, rheumatoid arthritis and obesity has been an important topic of study in recent decades. The Th17 pathway plays a significant role in how local inflammation can influence systemic inflammation in the absence of systemic pathology.

Inflammatory response

10.1590/1678-7757-2019-0490

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Citations (12)

Antisépticos orales para la disminución del riesgo de transmisión del COVID-19

Adriana Rodríguez Ciódaro Roger M. Arce Lina J. Suárez María Cecilia Martínez Pabón

10.11144/javeriana.9789587815382

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Citations (1)

Therapeutic effect of a topical CCR2 antagonist on induced alveolar bone loss in mice

Journal of Periodontal Research (2011)

S. P. Barros Roger M. Arce P. Galloway R. Lawter S. Offenbacher

Chemokines are known to regulate leukocyte trafficking, recruitment and infiltration in periodontal diseases. The study objective was to determine the effect of an experimental oral/topical chemokine (C-C motif) receptor 2 (CCR2)-antagonist treatment on alveolar bone loss in a mouse model of Porphyromonas gingivalis-induced periodontitis.Balb/C mice (n = 41) were randomly assigned to four groups. Group 1 was infected by P. gingivalis applied orally/topically for 5 wk. Group 2 was also infected and then treated with vehicle (aqueous methylcellulose) for an additional 4 wk. Group 3 was infected and orally/topically treated with CCR2 antagonist (10 mg/kg). Group 4 served as a noninfected, nontreated control group. Mice received intraperitoneal injections of Alizarin (30 mg/kg) and calcein (20 mg/kg) three times from the last day of infection to determine mineral deposition, reflecting bone dynamics. Mandibles were analysed by morphometry and confocal fluorescence microscopy.Alveolar bone loss was compared among groups using Tukey's test, and bone formation was qualitatively observed. Infected mice showed significantly greater alveolar bone loss than noninfected control animals (group 1 vs. 4, p < 0.01). Vehicle-treated mice (group 2) showed the largest area of alveolar bone loss (p < 0.01), while mice treated with the CCR2 antagonist showed the smallest area of alveolar bone loss and were similar to the control group (group 3 vs. 4, p = 0.14). Qualitative analysis of fluorescent dye uptake indicated increased bone formation in CCR2-antagonist-treated mice, suggesting an improved bone repairing process.The results suggested that treatment with CCR2 antagonist inhibited alveolar bone loss and improved bone formation in this model. These data support further evaluation of CCR2 antagonist as a therapeutic target for the development of new treatment modalities on bacterially induced alveolar bone resorption.

Intraperitoneal injection

CCR2

Calcein

10.1111/j.1600-0765.2010.01340.x

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Microorganismos inusuales en surcos y bolsas periodontales.

Colombia medica (2006)

Marisol Betancourth Roger M. Arce Javier Enrique Botero Adriana Jaramillo Carlos Cruz

Introduccion : Los microorganismos de la familia Enterobacteriaceae, los bacilos Gram negativos no fermentadores y ciertas especies de Candida se han considerado como inusuales en quienes sufren enfermedad periodontal, y en ellos el tratamiento mecanico o antimicrobiano puede ser poco efectivo para resolver o controlar la progresion de la enfermedad. Objetivos : Analizar los perfiles microbiologicos en individuos sanos y en pacientes con diagnostico de periodontitis cronica y periodontitis agresiva, determinar la frecuencia de los microorganismos inusuales y las posibles asociaciones con algunos microorganismos periodontopaticos en la base de datos del laboratorio de microbiologia oral y periodontal en Cali. Materiales y metodos : Se estudiaron los informes microbiologicos de 356 pacientes en un periodo de 41 meses. Las variables analizadas fueron: diagnostico periodontal, recuento total de colonias, porcentaje de aislamiento de diez microorganismos periodontopaticos y de otros inusuales como miembros de la familia Enterobacteriaceae, bacilos Gram negativos no fermentadores y levaduras. Resultados : Se analizaron 202 (56.7%) informes de pacientes con periodontitis cronica, 139 (39.1%) de periodontitis agresiva y 15 (4.2%) de individuos periodontalmente sanos. La presencia de microorganismos inusuales de tipo enterico fue 36% y la prevalencia de levaduras 7% en las personas con periodontitis. No se encontraron diferencias significantes entre los tres diagnosticos clinicos con respecto a la presencia de microorganismos entericos y levaduras. La mayor prevalencia de organismos entericos correspondio a los generos Klebsiella, Enterobacter y a bacilos Gram negativos no fermentadores. Se encontraron asociaciones estadisticamente significativas entre la presencia o ausencia de microorganismos infrecuentes con la de algunos microorganismos periodontopaticos en los individuos con enfermedad periodontal. Discusion y conclusiones : La microbiota inusuales de los pacientes incluidos en este estudio presento una mayor proporcion de bacilos Gram negativos entericos. Las bacterias entericas encontradas se caracterizan por ser agentes oportunistas para el hombre. Se requieren mas estudios para determinar el papel que los microorganismos inusuales pueden tener en la patogenesis y/o progresion de la enfermedad periodontal.

10.25100/cm.v37i1.406

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Citations (12)

Occurrence of Periodontopathic and Superinfecting Bacteria in Chronic and Aggressive Periodontitis Subjects in a Colombian Population

Journal of Periodontology (2007)

Javier Enrique Botero Adolfo Contreras Gloria Inés Lafaurie Adriana Jaramillo Marisol Betancourt-Quiroz

Background: Differences in the composition of subgingival microbiota in periodontitis have been observed in different geographic locations. Some of these microbial differences could have clinical significance. This study describes clinical parameters and the composition of the subgingival microbiota in chronic periodontitis (CP) and aggressive periodontitis (AgP) patients in a Colombian population. Methods: Clinical parameters (probing depth, clinical attachment level, bleeding on probing, and plaque index) and plaque samples from 68 CP, 12 AgP, and 30 periodontally healthy subjects were analyzed. Subgingival samples were processed using culture, biochemical tests, and polymerase chain reaction for the detection of periodontal and superinfecting pathogens. The analysis of variance, χ 2 , and Kruskal‐Wallis tests were used to evaluate differences between groups for clinical parameters and microbiologic composition ( P ≤0.05). Results: Clinical parameters were significantly increased in CP and AgP patients compared to healthy subjects ( P <0.001), but no differences were found between periodontitis groups. Porphyromonas gingivalis , Tannerella forsythensis , and Eikenella corrodens showed higher frequencies in AgP compared to CP and healthy subjects ( P <0.05). Extension (localized and generalized) of the periodontal destruction had no effect on the composition of the subgingival microbiota. Gram‐negative enteric rods were more frequent in AgP patients ( P <0.01). Conclusions: This study demonstrated a high prevalence of P. gingivalis , T. forsythensis , and E. corrodens in AgP patients. Gram‐negative enteric rods were frequent in AgP and CP patients. Differences in the composition of subgingival microbiota in periodontitis patients need to be taken into account when considering the best therapeutic approach for each individual, including the use of antibiotics.

Aggressive periodontitis

Eikenella corrodens

Clinical attachment loss

Bleeding on probing

10.1902/jop.2007.060129

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Citations (98)

Development of radiopaque, biocompatible, antimicrobial, micro-particle fillers for micro-CT imaging of simulated periodontal pockets

Dental Materials (2017)

Mahmoud Elashiry Mohamed M. Meghil Sajitha Kalathingal Allison Buchanan Mythilypriya Rajendran

Radiodensity

Streptococcus gordonii