Dave G. Mumby

Concordia University

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John P. J. Pinel

University of British Columbia

Melissa J. Glenn

Metropolitan State University of Denver

Stéphane Gaskin

McGill University

Emma R. Wood

University of Edinburgh

Tom J. Kornecook

Merck & Co., Inc., Rahway, NJ, USA (United States)

Nicole Gervais

University of Toronto

Emily Cole

Concordia University

Hugo Lehmann

Trent University

Dan Madularu

Carleton University

Anthony G. Phillips

University of British Columbia

Cooperative Institutions

Concordia University

University of British Columbia

McGill University

University of New Mexico

University of Toronto

McMaster University

Research Triangle Park Foundation

University of Lethbridge

Douglas Mental Health University Institute

University of Alberta

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Object familiarization and novel-object preference in rats

Behavioural Processes (2009)

Stéphane Gaskin Marilyn Tardif Emily Cole Pavel Piterkin Lima Kayello

Sample (material)

Preference test

10.1016/j.beproc.2009.10.003

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Citations (127)

Impaired allocentric spatial working memory and intact retrograde memory after thalamic damage caused by thiamine deficiency in rats.

Behavioral Neuroscience (1999)

Dave G. Mumby Luisa Cameli Melissa J. Glenn

Rats were tested on an allocentric-spatial working-memory task--delayed matching-to-place (DMTP) in a water maze--before and after either pyrithiamine-induced thiamine deficiency (PTD) or electrolytic lesions of the lateral internal medullary laminae (IML), an area damaged by PTD. DMTP trials consisted of paired swims, with the escape platform in a new location on each trial. PTD rats were impaired at retention delays of 300 s, but not at delays of 4 or 60 s. Rats with IML lesions performed normally at all delays. Both groups displayed normal retention of object-discrimination problems that they had learned at different intervals before treatment (5 weeks, 3 weeks, and 1 week). The results suggest that PTD causes delay-dependent deficits of allocentric spatial working memory and that damage outside the IML is probably responsible. Neither PTD-induced diencephalic damage nor restricted IML lesions appear to produce a global retrograde amnesia.

Retrograde amnesia

Memory disorder

Mammillary body

Water maze

10.1037/0735-7044.113.1.42

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Citations (16)

Dissociation in retrograde memory for object discriminations and object recognition in rats with perirhinal cortex damage

Behavioural Brain Research (2002)

Dave G. Mumby Melissa J. Glenn Catherine Nesbitt Diana Kyriazis

Perirhinal cortex

Discrimination learning

10.1016/s0166-4328(01)00444-2

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Citations (120)

Ischemia-induced object-recognition deficits in rats are attenuated by hippocampal ablation before or soon after ischemia.

Behavioral Neuroscience (1996)

Dave G. Mumby Emma R. Wood Christopher A. Duva Tom J. Kornecook John P. J. Pinel

The literature on the role of the hippocampus in object-recognition contains a paradox: Transient forebrain ischemia (ISC) produces hippocampal damage and severe deficits on the delayed nonmatching-to-sample (DNMS) task, yet hippocampal ablation (ABL) produces milder deficits. Experiment 1 confirmed that pretrained rats display severe DNMS deficits following ISC, but not ABL. Ischemia produced loss of CA1 neurons, but no obvious extrahippocampal damage. In Experiments 2 and 3, ISC rats from Experiment 1 received ABL, and ABL rats received ISC; neither treatment affected DNMS performance. In Experiment 4, rats that received ISC followed 1 hr later by ABL displayed only mild deficits. It is hypothesized that ISC-induced DNMS deficits are due to extrahippocampal damage produced by pathogenic processes that involve the hippocampus.

Forebrain

10.1037//0735-7044.110.2.266

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Citations (90)

The development of a rat model of brain-damage-produced amnesia

Dave G. Mumby

Brain damage

10.14288/1.0098895

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Citations (0)

Perirhinal cortex damage and anterograde object-recognition in rats after long retention intervals

Behavioural Brain Research (2007)

Dave G. Mumby Pavel Piterkin Valerie Lecluse H. Lehmann

Perirhinal cortex

10.1016/j.bbr.2007.07.026

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Citations (74)

Oxytocin and object preferences in the male prairie vole

Peptides (2014)

Dan Madularu Maria Athanassiou Jason R. Yee William M. Kenkel C. Sue Carter

Prairie vole

Oxytocin receptor

Arvicolinae

Vole

10.1016/j.peptides.2014.08.015

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Citations (8)

Memory for Objects, Places, and Contexts Hippocampal Damage and Exploratory Preferences in Rats:

Dave G. Mumby Stéphane Gaskin Melissa J. Glenn

Exploratory research

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Citations (2)

Attenuation of dendritic spine density in the perirhinal cortex following 17β-Estradiol replacement in the rat

Hippocampus (2015)

Nicole Gervais Dave G. Mumby Wayne G. Brake

Intraperirhinal cortex infusion of 17-β estradiol (E2) impairs object-recognition memory. However, it is not currently known whether this hormone modulates synaptic plasticity in this structure. Most excitatory synapses in the central nervous system are located on dendritic spines, and elevated E2 levels influence the density of these spines in several brain areas. The goal of the present study was to determine whether differences in dendritic spine density in the perirhinal cortex are observed following high E2 replacement in ovariectomized rats. The density of total spines, and mushroom-shaped (i.e. mature) spines were compared between a high E2 replacement (10 µg/kg/day, s.c.) and a no replacement condition. The perirhinal cortex is subdivided into Broadmann's area 35 and 36 and so group comparisons were made within each sub-region separately. High E2 replacement resulted in lower density of mushroom-shaped spines in area 35 relative to no replacement. There was no effect of high E2 replacement on dendritic spine density in area 36. These findings are consistent with the idea that higher E2 levels reduce dendritic spine density in area 35, which may result from spine shrinkage, or reduced synapse formation. This study provides preliminary evidence for a mechanism through which E2 may impair object-recognition memory.

Perirhinal cortex

10.1002/hipo.22479

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Citations (7)

Object Recognition

Oxford University Press eBooks (2004)

Dave G. Mumby

Abstract This chapter discusses object recognition in rats. It describes the two paradigms most often used to assess object recognition in rats: delayed nonmatching-to-sample (DNMS) and novel-object-preference (NOP). It shows that despite superficial similarities, DNMS and NOP tests engage different behavioral and motivational systems and therefore entail different procedural pitfalls and interpretational challenges. Still, findings from lesion experiments using either task have so far been fairly consistent, suggesting that the hippocampus is not critical for object-recognition memory, whereas the perirhinal cortex plays a more significant role. These conclusions are consistent with findings of changes in single-unit responses and c-fos expression within the perirhinal cortex produced by repeatedly presented visual stimuli.

Perirhinal cortex

10.1093/acprof:oso/9780195162851.003.0036

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Citations (1)