Rodrigo Arroyo

Universidad del Desarrollo

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Patrick Aloy

Institució Catalana de Recerca i Estudis Avançats

ÁR

Ángel R. Nebreda

Spanish National Cancer Research Centre

Begoña Cánovas

Institute for Research in Biomedicine

Ana Igea

Navarre Institute of Health Research

Modesto Orozco

Institute for Research in Biomedicine

Víctor Alcalde

Translational Therapeutics (United States)

Samira Jaeger

Institute for Research in Biomedicine

Francisco Cerić

Universidad del Desarrollo

Marcelo Pizarro

Pontificia Universidad Católica de Chile

Paulina Arango

Millennium Science Initiative

Cooperative Institutions

Pontificia Universidad Católica de Chile

Institute for Research in Biomedicine

Centre For Sustainable Urban Development

Universidad del Desarrollo

Universitat Politècnica de Catalunya

Universitat de Barcelona

Universidad del Desarrollo del Estado de Puebla

Millennium Science Initiative

Universidad Andrés Bello

Institució Catalana de Recerca i Estudis Avançats

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Supplementary Figure 13 from Quantification of Pathway Cross-talk Reveals Novel Synergistic Drug Combinations for Breast Cancer

Samira Jaeger Ana Igea Rodrigo Arroyo Víctor Alcalde Begoña Cánovas

Distribution of DCI values (DCI20 to DCI80) ranging from 20 to 80% of proliferation inhibition (IC20 to IC80) for DC01 to DC10.

Cancer drugs

10.1158/0008-5472.22415243.v1

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Supplementary Figure 7 from Quantification of Pathway Cross-talk Reveals Novel Synergistic Drug Combinations for Breast Cancer

Samira Jaeger Ana Igea Rodrigo Arroyo Víctor Alcalde Begoña Cánovas

Sigmoid-fitted dose-response curves generated for each of the experimentally validated drug combinations in the five cell lines.

10.1158/0008-5472.22415240

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Supplementary Table 5 from Quantification of Pathway Cross-talk Reveals Novel Synergistic Drug Combinations for Breast Cancer

Samira Jaeger Ana Igea Rodrigo Arroyo Víctor Alcalde Begoña Cánovas

Overview on the predicted drug combinations together with the pathways mainly involved in crosstalk inhibition (Excel table).

Crosstalk

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10.1158/0008-5472.22415231

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Funciones Ejecutivas Bien Temperadas: Bases Conductuales de la Regulación de Funciones Ejecutivas por Emociones

Psykhe (Santiago) (2019)

Francisco Cerić Cristián Cortés-Rivera Catalina Arrau Andrea Mira Rodrigo Arroyo

Tradicionalmente, la investigación de las funciones ejecutivas (FE) se ha centrado en tareas estructuralmente simples y neutras, en cuanto al componente afectivo. Esto se contrapone a un modelo más ecológico de la cognición, en el que el procesamiento emocional es parte activa y constitutiva del proceso cognitivo (Ceric, 2012; Lewis & Todd, 2007; Pessoa, 2009)

10.7764/psykhe.28.5.1698

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Supplementary Figure 13 from Quantification of Pathway Cross-talk Reveals Novel Synergistic Drug Combinations for Breast Cancer

Samira Jaeger Ana Igea Rodrigo Arroyo Víctor Alcalde Begoña Cánovas

Distribution of DCI values (DCI20 to DCI80) ranging from 20 to 80% of proliferation inhibition (IC20 to IC80) for DC01 to DC10.

10.1158/0008-5472.22415243

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Supplementary Table 1 from Quantification of Pathway Cross-talk Reveals Novel Synergistic Drug Combinations for Breast Cancer

Samira Jaeger Ana Igea Rodrigo Arroyo Víctor Alcalde Begoña Cánovas

Complete list of breast cancer drugs (Excel table).

Table (database)

10.1158/0008-5472.22415234.v1

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Data from Quantification of Pathway Cross-talk Reveals Novel Synergistic Drug Combinations for Breast Cancer

Samira Jaeger Ana Igea Rodrigo Arroyo Víctor Alcalde Begoña Cánovas

<div>AbstractCombinatorial therapeutic approaches are an imperative to improve cancer treatment, because it is critical to impede compensatory signaling mechanisms that can engender drug resistance to individual targeted drugs. Currently approved drug combinations result largely from empirical clinical experience and cover only a small fraction of a vast therapeutic space. Here we present a computational network biology approach, based on pathway cross-talk inhibition, to discover new synergistic drug combinations for breast cancer treatment. In silico analysis identified 390 novel anticancer drug pairs belonging to 10 drug classes that are likely to diminish pathway cross-talk and display synergistic antitumor effects. Ten novel drug combinations were validated experimentally, and seven of these exhibited synergy in human breast cancer cell lines. In particular, we found that one novel combination, pairing the estrogen response modifier raloxifene with the c-Met/VEGFR2 kinase inhibitor cabozantinib, dramatically potentiated the drugs' individual antitumor effects in a mouse model of breast cancer. When compared with high-throughput combinatorial studies without computational prioritization, our approach offers a significant advance capable of uncovering broad-spectrum utility across many cancer types. Cancer Res; 77(2); 459–69. ©2016 AACR.</div>

Cabozantinib

Raloxifene

10.1158/0008-5472.c.6509207

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¿Pruebas Tradicionales o Evaluación Invisible a Través del Juego? Nuevas Fronteras de la Evaluación Cognitiva Traditional Assessment or Invisible Assessment Using Games? New Frontiers in Cognitive Assessment

Ricardo Rosas Francisco Cerić Andrés Aparicio Paulina Arango Rodrigo Arroyo

Se aborda el problema de ansiedad relacionado con las evaluaciones tradicionales, que pueden afectar los resultados y subestimar el rendimiento de los sujetos. Las evaluaciones invisibles permiten evaluar a los sujetos sin que estos tengan la sensacion de ser evaluados. Se desarrollaron pruebas de evaluacion invisible en soporte tableta tactil, considerando los dominios cognitivos de inteligencia, calculo y lectura, las que fueron aplicadas a 337 ninos, entre kinder y tercero basico, de 3 colegios particulares subvencionados de Santiago, Chile. Los colegios fueron seleccionados por conveniencia, incluyendo a todos los ninos cuyos padres firmaron consentimiento informado. La muestra final se distribuyo al azar entre los dominios. Se observaron correlaciones entre las pruebas de evaluacion tradicional e invisible. Los ninos reportaron una preferencia por las pruebas de evaluacion invisible por sobre las tradicionales. Segun un analisis mixto de varianza, los ninos con bajo rendimiento escolar obtuvieron mejores resultados en las pruebas de evaluacion invisible que en las tradicionales. Los resultados sugieren que es posible evaluar dominios cognitivos con instrumentos no tradicionales, permitiendo estos el acceso al rendimiento real de los sujetos. Palabras clave: evaluacion, ansiedad, juego This paper addresses the problem of anxiety related to traditional assessment, which can affect assessment outcomes and underestimate the performance of subjects. Invisible assessment makes it possible to evaluate subjects without making them feel like they are being evaluated. Invisible evaluation tests were developed for touch screen tablets for 3 cognitive domains: intelligence, calculation, and reading. These tests were applied to 337 children from kindergarten through third grade, who attended 3 mixed-funding schools in Santiago, Chile. The schools were convenience sampled and all the children whose parents signed the informed consent form were included. The final sample was randomly distributed among the domains. Correlations between traditional assessment tests and invisible assessment tests were observed. Children reported a preference for invisible assessment over traditional assessment. Subjects with low academic performance obtained better scores on invisible assessment tests than on traditional tests, according to a mixed factors analysis of variance. These findings suggest that it is possible to assess cognitive domains with nontraditional instruments and that they can reveal the real academic performance of subjects.

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The role of executive functions in the relation between socioeconomic level and the development of reading and maths skills / El rol de las funciones ejecutivas en la relación entre el nivel socioeconómico y el desarrollo de habilidades lectoras y matemáticas

Culture and Education (2018)

José‐Pablo Escobar Ricardo R. Rosas-Díaz Francisco Cerić Andrés Aparicio Paulina Arango

Executive functions (EF) are a set of processes that allow individuals to plan, monitor and organize tasks and thus play a key role in the development of reading and maths skills. Environmental factors such as socioeconomic level (SEL) influence reading and maths skills as well as EFs. The aim of this study is to explore the extent to which executive functions play a mediating role between SEL and reading and maths performance. To this end, we assessed 286 Chilean primary education students: 86 with a high SEL and 200 with a low level. The results show that the high-SEL group obtained consistently higher scores than their peers with low SEL levels in both reading and maths tasks as well as in EF measurements. This suggests that SEL could influence the development of these variables. The results also showed that EFs partially mediate the relation between SEL and reading and maths skills in primary school students through the specific function of inhibition. The results are discussed in light of the effect of SEL on the development of EFs and school learning.

10.1080/11356405.2018.1462903

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Supplementary Material, Supplementary Tables 2 through 4, 6 and 7, and Supplementary Figures 1 through 6, 8 through 12, and 14 from Quantification of Pathway Cross-talk Reveals Novel Synergistic Drug Combinations for Breast Cancer

Samira Jaeger Ana Igea Rodrigo Arroyo Víctor Alcalde Begoña Cánovas

The Supplementary Material File contains specific methodological information as well as additional results related (and cited) in the main manuscript. In particular, it contains six sections providing information on: S1) Experimental validation of drug combinations in human cancer cell lines, S2) Impact of the Residual Standard Error, S3) In vivo xenograf model, S4) Functional relationships among KEGG pathways, S5) Efficacy of clinically relevant drug combinations with respect to the PCI and S6) Enrichment of synergistic combinations in comparison with high-throughput experimental screens.

KEGG

10.1158/0008-5472.22415237.v1

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