Leber Hw

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Co-Authors

G Schütterle

University of Giessen

G Goubeaud

Universitätsklinikum Gießen und Marburg

E Degkwitz

University of Giessen

P Rawer

PHV Dialysezentrum

Rita Spiegelhalter

Universitätsklinikum Gießen und Marburg

H. Staudinger

Institute of Macromolecular Chemistry

D. Post

Advocate Health Care

Ulm A

Universitätsklinikum Gießen und Marburg

Wizemann

PHV Dialysezentrum

Bernd Leinweber

Medical University of Graz

Cooperative Institutions

University of Giessen

Universitätsklinikum Gießen und Marburg

Johannes Gutenberg University Mainz

Heidelberg University

Giessen School of Theology

PHV Dialysezentrum

University Hospital Heidelberg

Max Planck Society

Saarland University

University of Freiburg

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Citation

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A new aspect of uraemic haemolysis: increased susceptibility of erythrocytes to peroxidation.

PubMed (1978)

Leber Hw Rita Spiegelhalter G Schütterle

Haemolysis

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Citations (6)

[Studies on psychophysical ability of dialysis patients with regard to the question of driving aptitude].

PubMed (1982)

G. Schewe T. Eisenhauer Leber Hw Udo K Lindner Oliver Ludwig

Aptitude

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Citations (1)

[The importance of medium sized molecules as uremia toxins].

PubMed (1979)

Leber Hw G Goubeaud Rita Spiegelhalter P Rawer

Uremia

Uremic Toxins

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Citations (1)

Potential role of middle molecular compounds in the development of uremic anemia.

PubMed (1981)

Leber Hw E. Sebastian Debus U Grulich G Schütterle

In preceding papers it was demonstrated that middle molecular fractions isolated from uremic patients (MM) impair hemoglobin synthesis by inhibiting the enzyme Delta-aminolevulinic acid dehydrase (D-ALA-D) and by diminishing the globin synthesis in reticulocytes from healthy subjects. Additionally, the susceptibility to oxidative damage of erythrocytes is increased in the presence of MM. Studies were undertaken to elucidate the underlying mechanisms. It was found that the MM induced D-ALA-D inhibition is reversed both by Zn and by GSH in vitro indicating that MM exert their effect on the enzyme either by affecting essential SH-groups within the enzyme molecule or by altering the enzyme configuration by interaction with the Zn atom. MM causing an increased oxidative hemolysis rate (OHR) also inhibit the catalase activity and the glucose consumption of normal and uremic erythrocytes. It is concluded that the augmented OHR in uremia is induced by accumulating hydrogen peroxide which cannot be sufficiently removed due to the MM mediated catalase inhibition and the concomitant impairment of the glucose utilisation.

Uremia

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Citations (2)

[Apparent Michaelis constant of acetanilide during its p-hydroxylation in liver microsomes of scorbutic guinea pigs].

PubMed (1970)

E Degkwitz Leber Hw LUCIA KAUFMANN H. Staudinger

Acetanilide

Hydroxylation

Michaelis–Menten kinetics

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Citations (0)

[Amanita phalloides poisoning. Course of amanita phalloides poisoning studied on 5 cases].

PubMed (1978)

Matthes Kj Leber Hw S Etesham-Schahabi H Gerhardt Wizemann

Amanita phalloides

Amanita

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Citations (1)

[Studies on the behavior of microsomal enzymes in the rat liver following galactosamine administration].

PubMed (1971)

Leber Hw Bernd Leinweber D Platt

Galactosamine

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Citations (1)

[Influence of aldactone on drug decomposing enzymes in the liver endoplasmic reticulum of rat and man].

PubMed (1972)

Leber Hw P Harders G Schütterle

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Citations (1)

[Porphyrin metabolism in chronic uremia].

PubMed (1978)

Leber Hw K Thielsen H. Bleyl

Uremia

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Citations (0)

Porphobilinogen and porphyrin synthesis in reticulocytes from uraemic patients.

PubMed (1975)

Leber Hw P Sinning G Schütterle

Since no information exists concerning porphyrin metabolism in uraemic patients we have measured the activities of delta-aminolaevulinic acid dehydrase (D-ALA-D) and porphobilinogen desaminase (PBG-D) in reticulocytes from uraemic patients, anaemic patients without uraemia and in healthy subjects. Despite a severe anaemia uraemic patients had the same amount of reticulocytes/mul blood. In uraemic patients D-ALA-D activity was reduced to about 20% compared to healthy subjects, PBG-D in uraemia was decreased to about 70%. It is concluded that porphyrin metabolism is altered in uraemic patients.

Porphobilinogen

Uremia

Porphobilinogen synthase

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Citations (5)