Paula Vasilache-Antohi

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Victoria Țău

Clinica de Pneumologie Iaşi

Antigona Trofor

Clinica de Pneumologie Iaşi

Adelina Stoian

Grigore T. Popa University of Medicine and Pharmacy

Radu Crișan-Dabija

Grigore T. Popa University of Medicine and Pharmacy

Andreea Zabara-Antal

Clinica de Pneumologie Iaşi

Adriana-Loredana Pintilie

Clinica de Pneumologie Iaşi

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Clinica de Pneumologie Iaşi

Grigore T. Popa University of Medicine and Pharmacy

Spitalul Clinic C.F. Iasi

University of Waterloo

Collegium Civitas

Romanian Waters National Administration

European Network for Smoking and Tobacco Prevention

Constanta Maritime University

Spitalul Clinic de Recuperare

Institut des Sciences et Technologies Moléculaires d'Angers

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Systemic inflammation and obstructive sleep apnea syndrome (OSA): the role of C–reactive protein (CRP)

Pneumologia (2023)

Adriana-Loredana Pintilie Andreea Zabara-Antal Paula Vasilache-Antohi Victoria Țău Adelina Stoian

Abstract The presence of sleep-related disorders, particularly obstructive sleep apnea syndrome (OSA), instigates pathological changes during sleep, giving rise to frequent hypoxic episodes that generate elevated levels of a broad spectrum of inflammatory cytokines. C-reactive protein (CRP), a biomarker signifying the presence and intensity of inflammation, is frequently detected in elevated serum or plasma concentrations, correlating with the number of respiratory events, especially in moderate and severe forms, across both adults and children. Various available therapeutic approaches demonstrate the capacity to diminish serum levels, although the minimum duration of usage typically extends between 2-6 months. In the case of older individuals, OSA commonly coexists with additional conditions, further augmenting the baseline inflammatory level. This accelerated disease progression amplifies mortality rates, incurs heightened costs, and significantly diminishes the overall quality of life.

Sleep

10.2478/pneum-2024-0002

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