A. Thibault-Espitia

Inserm

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Richard Danger

Institut de Transplantation Urologie en Nephrologie

Yohann Foucher

Inserm

Thi Migone

Human Genome Sciences (United States)

Magali Giral

Centre Hospitalier Universitaire de Nantes

Sophie Castagnet

Dynamique Microbienne associée aux Infections Urinaires et Respiratoires

Sophie Brouard

Inserm

J.P. Soulillou

Centre Hospitalier Universitaire de Nantes

Annaïck Pallier

Robert Bosch (Germany)

Anne Cesbron Gautier

Centre Pays de la Loire

Claire Guéguen

Adaptimmune (United Kingdom)

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Inserm

Nantes Université

Centre Hospitalier Universitaire de Nantes

Institut de Transplantation Urologie en Nephrologie

Center for Research in Transplantation and Translational Immunology

Université Paris Cité

Assistance Publique – Hôpitaux de Paris

Centre d'Investigation Clinique de Nantes

Établissement Français du Sang

Institut du Thorax

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BAFF and BAFF-R Levels Are Associated With Risk of Long-Term Kidney Graft Dysfunction and Development of Donor-Specific Antibodies

American Journal of Transplantation (2012)

A. Thibault-Espitia Yohann Foucher Richard Danger Thi Migone Annaïck Pallier

There are lines of evidence that B cells may play a role in transplantation. B cell activating factor, BAFF, is a homotrimer that has been shown to play a role in B cell survival, maturation and activation. To date, little is known of the role of BAFF and its receptors in transplantation. We analyzed the level of BAFF mRNA and its soluble protein, as well as transcripts coding for its receptors, BAFF-R, TACI and BCMA, in the blood of 143 patients with stable kidney transplant function 5 years or more posttransplantation. Three endpoints were analyzed: the time to renal dysfunction, the time to appearance of anti-HLA antibodies and the time to development of donor-specific antibodies. We established threshold values for BAFF and BAFF-R and showed that (1) stable patients with high BAFF-R levels had a higher risk of developing graft dysfunction, (2) patients with lower levels of BAFF transcripts or a higher level of soluble BAFF had a significantly higher risk of developing donor-specific antibodies. These data suggest that BAFF constitutes a risk factor for renal graft dysfunction and development of donor-specific antibodies. They also suggest that agents targeting BAFF-R interactions may offer new therapeutic opportunities in transplantation.

10.1111/j.1600-6143.2012.04194.x

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