Ali SR

University of Glasgow

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Feyza Darendelıler

Istanbul University

Krone NP

University of Sheffield

Bachega TASS

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Isidori AM

Rotterdam University of Applied Sciences

Ayla Güven

Başkent University

de Vries L

Oxford Centre for Diabetes, Endocrinology and Metabolism

V Thornton-Jones

Oxford Centre for Diabetes, Endocrinology and Metabolism

Wiebke Arlt

University of Birmingham

Ross Rj

University of Sheffield

Riccardo Pofi

Oxford Centre for Diabetes, Endocrinology and Metabolism

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Radboud University Nijmegen

University of Sheffield

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Oxford Centre for Diabetes, Endocrinology and Metabolism

University of Oxford

University of Birmingham

Owl Research Institute

Sapienza University of Rome

Churchill Hospital

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Plasma renin measurements are unrelated to mineralocorticoid replacement dose in patients with primary adrenal insufficiency

Yearbook of pediatric endocrinology (2020)

Riccardo Pofi Alessandro Prete V Thornton-Jones Jilian Bryce Ali SR

Mineralocorticoid (MC) replacement therapy along with glucocorticoid (GC) replacement is crucial to avoid life-threating adrenal crises in Addison´s disease (AD) and in classical CAH (13). MC is administered with the aim of achieving plasma renin concentration (PRC) within the upper limit of the reference range. Taking into account the complex regulation of PRC, this study explored the relationship between MC dose regimens and clinical and biochemical variables in clinical practice to determine whether those variables can be used to guide titration of MC dosing.

Mineralocorticoid

Primary Adrenal Insufficiency

Plasma renin activity

10.1530/ey.17.8.17

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