M. M.J.F. Prickartz‐Wijdeveld

Radboud University Nijmegen

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G. H. J. Boers

Radboud University Nijmegen

P.R. Hein

Radboud University Nijmegen

Léon G.M. Mulders

University of Amsterdam

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Radboud University Nijmegen

Radboud University Medical Center

General Department of Preventive Medicine

Catholic University of America

Nijmegen Institute for Scientist Practitioners in Addiction

Vrije Universiteit Amsterdam

University of Amsterdam

Amsterdam University Medical Centers

Máxima Medisch Centrum

Christie's

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A Study of maternal ecg characteristics before and during intravenous tocolysis with β‐sympathicomimetics

Acta Obstetricia Et Gynecologica Scandinavica (1987)

Léon G.M. Mulders G. H. J. Boers M. M.J.F. Prickartz‐Wijdeveld P.R. Hein

Severe maternal complications during beta-mimetic therapy have been reported. In a study of maternal complications related to intravenous tocolysis, which covering a period of 2 years, we paid special attention to the maternal ECG before and during treatment. There was a high prevalence of pretreatment ECG changes: tachycardia (23.6%), disorders of impulse conduction (43.6%), ST-depression (14.5%) and disorders of repolarization (43.6%). During intravenous beta-mimetic therapy there was an increase in the prevalence of tachycardia, prolonged QT-time and disorders of repolarization. We also studied the course in time of the different ECG characteristics during treatment. With regard to the ST-depression, a possible physiological adaptation to the beta-mimetic drug is described. We could not find this possible adaptation with regard to the other ECG characteristics. None of the women in the studied group showed clinical signs of myocardial ischemia, notwithstanding the high prevalence of ECG changes. We conclude that the ECG criteria for discontinuation of tocolytic therapy need re-evaluation.

Discontinuation

ST depression

Premature atrial contraction

Depression

10.3109/00016348709022045

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