AIM:To compare the visual and optical performance of eyes with different corneal spherical aberration(SA) implanted with spherical aberration-free intraocular lens(IOLs).· METHODS:Thirty-six patients with different corneal SA had phacoemulsification with implantation of spherical aberration-free IOLs.Patients were divided into 3 groups according to the value of preoperative corneal SA.Eyes with corneal SA <0.10μm were assigned to group A,those with 0.10 ≤corneal SA <0.20μm to Group B,and those with 0.20≤corneal SA <0.35μm to Group C.Best-corrected visual acuity(BCVA),contrast sensitivity,corneal SA,total ocular aberrations,and depth of focus were recorded 3 months postoperatively.Distance-corrected near and intermediate visual acuity was studied to measure depth of focus.· RESULTS:BCVA and contrast sensitivity were similar between groups.There were no significant differences in distance-corrected near or intermediate visual acuity.Corneal SA was similar before and 3 months after surgery in the 3 groups.With a 5.0mm pupil diameter,root mean square values for total ocular higher-order aberrations(HOAs) were lower in groups A and B than in group C.Total ocular SA was lower in group A than in groups B and C.SA was also lower in group B than in group C.Coma and trefoil were similar between the groups.· CONCLUSION:Implantation of spherical aberration-free IOLs in eyes with different corneal SA results in similar visual performance at BCVA,contrast sensitivity and depth of focus.