Kumara Swamy Jella

Chaitanya Hospital And Nursing Home

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Kavati Shireesha

Chaitanya Hospital And Nursing Home

Kasaboina Kalyani Priya

Chaitanya Hospital And Nursing Home

Vikash Kumar

Indian Institute of Technology Tirupati

D. Ravi

Indian Institute of Chemical Technology

K. Krishna Priya

University of Kerala

Venkata Konda Prasad B

G. Venkata Haritha

Mahesh Ellanti

S. Kavitha

Yes Technologies (United States)

A Divya

Kakatiya University

Cooperative Institutions

University of Hyderabad

Kakatiya University

Chaitanya Hospital And Nursing Home

Indian Institute of Technology Tirupati

Indian Law Institute

Birla Institute of Technology and Science, Pilani - Goa Campus

Bharath University

Birla Institute of Technology and Science, Pilani

Guru Teg Bahadur Hospital

Institut Teknologi dan Sains Mandala

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Green Construction of Novel 3‐(Benzo[d][1,3]dioxol‐5‐yl)‐1,8‐naphthyridin‐2‐yl)amino)quinazoline‐2,4(1H,3H)‐dione and Phenyl‐[1,2,4]triazolo[4,3‐a][1,8]naphthyridine and Their Antimicrobial Activity

Journal of Heterocyclic Chemistry (2024)

S. Hari Krishna Reddy Kavati Shireesha Kumara Swamy Jella

ABSTRACT A straightforward and an efficient green synthetic method has been outlined for the construction of 3‐(benzo[d][1, 3] dioxol‐5‐yl)‐1,8‐naphthyridine derivatives in the presence of glacial acetic acid and Cu(OAc) 2 catalyst accomplished excellent yields in short reaction time. The reaction proceeds efficiently by using a greener way under microwave conditions to elevate the quantity of pure products. The purity of all the synthesized compounds was confirmed by IR, 1 H and 13 CNMR, LC–MS data and also from the elemental analyses studies. The synthesized compounds 7d and 7f performed strongest antibacterial activity against pathogenic cell lines Bacillus subtilis (17.5, 20.5 mm), Escherichia coli (28.5, 30 mm), and antifungal cell lines Candida albicans (18, 22.5 mm), and Aspergillus Niger (28.5, 40.5 mm) which are compared with clinical drugs Penicillin, Grieseofulvin. We scrutinized the remaining molecules and found that their activity ranged from modest to exceptional.

Quinazoline

10.1002/jhet.4927

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ANTIBACTERIAL, ANTIFUNGAL ACTIVITY OF NEWLY SYNTHESIZED 1, 8-NAPHTHYRIDINYL HETEROCYCLES

Kavati Shireesha S. Kavitha Kumara Swamy Jella

Due to the utility of these composites as medicines, heterocyclic chemistry is veritably important to medicinal druggists. Multitudinous heterocyclic substances are being used as medicinal agents and are also necessary for mortal life. 1,8-Naphthyridine Derivations Are a Significant Class of Heterocyclic Chemicals Due to Their Wide Range of Natural Conduct. Numerous 1,8- naphthyridine derivations were created as a result of nalidixic acid's remarkable clinical effectiveness as an antibacterial medicine.

10.58532/v3becs9p4ch3

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Synthesis, Spectral Characterization of Novel 2,6-Disubstituted Pyrazine Derivatives, and Their Antimicrobial, Anti-Lung Cancer Properties and Molecular Docking Study

Venkata Konda Prasad B G. Venkata Haritha Kavati Shireesha Kumara Swamy Jella D. Ravi

Pyrazine

Docking (animal)

10.2139/ssrn.5018019

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Rational design, synthesis, and anti-cancer evaluation of amide derivatives of 1,3,4-Thiadiazole benzimidazoles

Results in Chemistry (2024)

Vikash Kumar Muralasetti Nookaraju Kumara Swamy Jella Laxminarayana Eppakayala

Amide

Rational design

10.1016/j.rechem.2024.101718

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Rational design, synthesis, and antimicrobial evaluation of novel imidazo[1,2-a][1,8]naphthyridine based thiazole and chromenone scaffolds

ARKIVOC (2025)

Mahesh Ellanti A Divya Kavati Shireeshaa Kumara Swamy Jella

Thiazole

Rational design

10.24820/ark.5550190.p012.341

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Synthesis and biological evaluation of 1,2,4-Triazolo[4,3-a][1,8] naphthyridines under Microwave condition

Chemical Biology Letters (2024)

Kasaboina Kalyani Priya Kumara Swamy Jella

Synthesis of 9-(4-bromophenyl)-6 aryl-[1,2,4]triazolo[4,3-a][1,8]naphthyridine-2-carbonitrile (4a-j) from 7-(2-(4bromobenzylidene)hydrazinyl)-6-aryl-1,8-naphthyridine-2-carbonitrile (3) oxidized with chloramines-T in methanol under microwave irradiation is a straight forward and very efficient process. Very high yields and excellent purities of the products were achieved. Elemental analysis, IR, 1H NMR, 13C NMR and Mass spectroscopy are used to characterize the produced compounds. All synthesized compounds were tested for their antimicrobial efficacy and found moderately active against different types of bacterial and fungal strains in comparison with Streptomycin, Nystatin. URN:NBN:sciencein.cbl.2024.v11.664

10.62110/sciencein.cbl.2024.v11.664

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Synthesis of Biological Potent Novel 3-(3,5-Bis(Trifluoromethyl) Phenyl)-N-Aryl-1,8-Naphthyridine Derivatives and in Vitro Antimicrobial, and Anticancer Activity

Kumara Swamy Jella K. Krishna Priya Kavati Shireesha

10.2139/ssrn.4873617

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Facile Synthesis of new 7-morpholino-6-(Aryl-1,3,4-oxadiazol)-1,8-naphthyridines and, evaluation of Antimicrobial and molecular Docking studies

Research Square (Research Square) (2024)

Kasaboina Kalyani Priya Kavati Shireesha Kumara Swamy Jella

Abstract The new series of biologically potential antibacterial and anti-fungal agents of 7-morpholino-6-(5-ary-1,3,4-oxadiazol)-1,8-naphthyridine-2-carbonitrile scaffolds successfully synthesised by using the mild catalyst (FeCl₃.6H₂O) obtained good yields. The structures of the newly synthesized final target molecules established by various techniques IR, ¹H NMR, ¹³C NMR, and Mass data. Activity of In vitro Antimicrobial studies of the new products were investigated against bacterial and fungal strains in compare with the clinical drugs Ampicillin, Grieseofulvin, compounds 7c and 7g demonstrated highest activity against pathogenic strains. Moreover, products were docked against target protein receptor (PDB ID: 8g4d), Docking results displayed that 7c and 7g are excellent binding interactions with the protein.

Morpholino

Docking (animal)

10.21203/rs.3.rs-4460421/v1

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